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Life changing gamble ... worth it? would you even consider it?
possibly the ultimate gamble ... just wondering what others thoughts are on it
The options if the poll works is either yes or no
The question is .... would you risk a possibly painfull death for a 1/3rd extra time in your life
if you make it to 100 thats only 36524 days you have to live (not a very big number really ) ... a 3rd of that you will spend sleeping on average
What if you could choose never to sleep again? or only sleep for 1 hour a day ... what could you do with those extra 7-8 (+) hours? (49+ hours = an extra two days a week to do what you want!)
the downsides to gaining a 3rd extra time to use in this life are
(lifted from wiki -http://en.wikipedia.org/wiki/Modafinil)
Contraindications and warnings
Literature distributed by maker Cephalon advises that it is important to consult with your physician before using Modafinil, particularly for those with:
* Hypersensitivity to the drug or other constituents of the tablets, or
* Previous cardiovascular problems, particularly while using other stimulants, or
* Cirrhosis, or
* Cardiac conditions, particularly:
o Left ventricular hypertrophy, or
o Mitral valve prolapse.
+ Asymptomatic MVP is not uncommon, but neither is it prominently discussed in Modafinil's context.
Although it is not discussed in the literature, the standard binders used for Modafinil contain wheat gluten, and so persons who have Coeliac Disease (Celiac Disease) should avoid the drug.
 Severe adverse reactions
Modafinil may induce severe dermatologic reactions requiring hospitalization. From the date of initial marketing, December 1998, to January 30, 2007, FDA received six cases of severe cutaneous adverse reactions associated with modafinil, including erythema multiforme (EM), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) involving adult and pediatric patients. The FDA issued a relevant alert. In the same alert, the FDA also noted that angioedema and multi-organ hypersensitivity reactions have also been reported in postmarketing experience. "Modafinil (marketed as Provigil): Serious Skin Reactions". FDA. Fall, 2007. FDA Drug Safety Newsletter: Postmarketing Reviews.
See the ADHD section for discussion of transitions to modafinil from high dose stimulant regimens. Patients with severe anxiety should be carefully supervised, as modafinil may exacerbate their condition. It may be necessary to coadminister an anxiolytic. High blood pressure should be stabilized before initiating treatment with modafinil or any other stimulant. The patient should inform the prescribing physician of any other drugs they are currently taking, as modafinil may interact with a great number of drugs.
Relatively little is known regarding safety of modafinil during pregnancy or breastfeeding. Studies on pregnant rats and rabbits suggest that high doses of modafinil during pregnancy may increase the likelihood of birth defects. There are no adequate and well controlled trials with modafinil in pregnant women. Modafinil should only be used in pregnancy if the potential benefit for the mother justifies the potential risk to the fetus. It is not known if modafinil or its metabolites are excreted in human milk. Caution should be exercised when modafinil is administered to a nursing woman. Modafinil may reduce the effectiveness of contraceptives. While some sources recommend the avoidance of alcohol in combination with modafinil, the interaction between modafinil and alcohol has not yet been studied.
The most common side-effects observed with modafinil, as compared to placebo, when prescribed in the recommended doses for the approved indications, are as follows:
o Headache (34% vs 23%)
o Nausea (11% vs 3%)
* Less common
o Nervousness (7% vs 3%)
o Insomnia (5% vs 1%)
o Anxiety (5% vs 1%)
o Dizziness (5% vs 4%)
o Chest pain (3% vs 1%)
o Hypertension (3% vs 1%)
o Tachycardia (2% vs 1%)
o Vasodilatation (2% vs 0%)
o Dry mouth (4% vs 2%)
o Paresthesia (2% vs 0%)
o Pharyngitis (4% vs 2%)
o Anorexia (4% vs 1%)
In 2007, the FDA ordered Cephalon to modify the Provigil leaflet in bold-face print of several serious and potentially fatal conditions attributed to modafinil use, including TENS, DRESS syndrome, and most seriously, Stevens-Johnson Syndrome (SJS).
Additionally, gastrointestinal distress, which may be alleviated by taking the drug after a meal, aggressiveness and skin irritation have been reported, but are rare. Most side-effects subside after a few weeks without reducing the dose. Only headaches and anxiety have been shown to be proportional to dose, and these may benefit from a temporary reduction or dividing the dose. A single case of premature ventricular contractions appeared causally linked to administration of modafinil.
Modafinil may have an adverse effect on hormonal contraceptives, lasting for a month after cessation of dosage. Modafinil toxicity levels vary widely among species. In mice and rats, the median lethal dose LD50 of modafinil is approximately or slightly greater than 1250 mg/kg. Oral LD50 values reported for rats range from 1000 mg/kg to 3400 mg/kg. Intravenous LD50 for dogs is 300 mg/kg. In clinical trials on humans, taking up to 1200 mg/day for 7 to 21 days or one-time doses up to 4500 mg did not appear to cause life-threatening effects, although a number of adverse experiences were observed, including excitation or agitation, insomnia, anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, and diarrhea. As of 2004, FDA is not aware of any fatal overdoses involving modafinil alone (as opposed to multiple drugs, including modafinil). Consequently, oral LD50 of modafinil in humans is not known exactly. However, it appears to be higher than oral LD50 of caffeine.
Reason i ask is because there was a program where a pesron who had been taking only an hours sleep a day for the last year plus was shown (it seems the above is becoming more widly used)
That is the bad bits listed and there could be more down the line so if they cant put you off what would? (bloded the real nasty bits that you should maybe wiki before voting)
*just incase this isnt appropriot feel free to delete but i figured here would be an ideal place to ask seen as there is a mixture of slight and non risk takers
*grrrr just realised i missed 'maybe' as an option off the poll
I want to change my vote to yes but its not for me now, since im not going to do it. But i answered before i properly read the text, i just read the "life changing gamble... would you consider it" and just thought "hell yeah i will give it a go, whats the tip "
Have a plan and stick to it
Whats the point of living if you're not enjoying it?
Originally Posted by GlobalSquare
Have a plan and stick to it
im not averse to taking risks (as GS well knows). That said, I firmly believe there are some areas where you shouldnt really take risks. For me, health is most definitely one.
Ive gone for no, but maybe if it was safer. Having checked on everything in there (percentages, possible side effects etc), it just seems to me that the % of some side effects is too high to be a risk truly worth taking, especially given the possible health implications.
At the end of the day, I myself would prefer a better quality of life and a shorter one than to live longer and not enjoy it as much. If there were less risks involved, then i could maybe be swayed, but when manufacturers are forced to put bold print warnings on, then there is a fundamental flaw in the way the drugs currently are.