Champions Chelsea have the chance to go level with Manchester United in second place on Tuesday evening, whilst Burnley could move into fourth.
Chelsea boss Antonio Conte conceded the title to Manchester City after their weekend loss to West Ham United, but they are very much still in the mix.
They will move level with United if they can take three points at Huddersfield.
Should Burnley’s outstanding season continue with victory over beleaguered Stoke, then they would move up into fourth place, from seventh.
Bottom-of-the-table Crystal Palace have the chance to climb out of the relegation zone, with victory over Watford at Selhurst Park.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Burnley 19:45 Stoke City
TEAM NEWS: Burnley will make a late decision on both Matt Lowton and Ben Mee, who both have knee issues. Glen Johnson, Jese and Bruno Martin Indi all miss out for Stoke.
KEY FACT: Burnley are unbeaten in their three home Premier League matches against Stoke
MATCH ODDS: Burnley 13/10 Draw 11/5 Stoke 13/5
bet365 Pick: Both Teams To Score @Evens
ANDY SAYS: Tough game this, but Burnley at home on a winter’s night, have to go with them…2-1
GRAEME SAYS: I think Stoke have been poor recently so have to go Burnley…2-0
SILKY SAYS: Have to think Burnley will just about have too much for Stoke here…2-1
FOOTBALLIndex – One to follow: Xherdan Shaqiri is still a class act but not only jut over 70p
Crystal Palace 20:00 Watford
TEAM NEWS: Yohan Cabaye is set to be available but Mamadou Sakho and Joel Ward are sidelined. Marvin Zeegelaar is set for a suspension, whilst Miguel Britos and Kiko Femenia are doubtful.
KEY FACT: Crystal Palace have won four of their last six home league matches against Watford
MATCH ODDS: Palace 13/10 Draw 5/2 Watford 23/10
bet365 Pick: Palace to win and Both Teams To Score @10/3
ANDY SAYS: Another close game but I think my old club will get something here…1-1
GRAEME SAYS: I think Palace might just get the win they are looking for…2-1
SILKY SAYS: Watford are the better team so I can see them getting the three points…1-2
FOOTBALLIndex – One to follow: Wilfried Zaha at £1.42 still looks a very good buy
Huddersfield Town 20:00 Chelsea
John Smith’s Stadium
Live On BT Sport
TEAM NEWS: Huddersfield winger Raji van La Parra is available after suspension but Kasey Palmer is ineligible to face his parent club. Danny Drinkwater should be available again for Chelsea following illness.
KEY FACT: Huddersfield have won three of their last four Premier League home matches
MATCH ODDS: Huddersfield 8/1 Draw 7/2 Chelsea 4/9
bet365 Pick: Tom Ince to score anytime @11/2
ANDY SAYS: Won’t be easy this and I will just go Chelsea but I could see them slipping up…1-2
GRAEME SAYS: Have to think that Chelsea will come out on top, but not easy…0-1
SILKY SAYS: I can see a comfortable win here for Chelsea…1-4
FOOTBALLIndex – One to follow: Tom Ince at just over 70p and out the top-300 could be interesting