Leaders Manchester City are looking to bounce back from their first defeat of the season on Saturday.
City lost at Liverpool to end their fantastic start to the campaign, but they will will be looking to return to winning ways as they host Newcastle in the late kick-off on Saturday.
Should City slip-up again, then second placed Manchester United will have the chance to cut the gap at the top to nine points as they make the short trip across Lancashire to face seventh placed Burnley.
With third placed Liverpool not in action until Monday – Chelsea in third have the chance to move back into third as they open the weekend’s programme at Brighton.
Arsenal in sixth will look to close the gap on rivals Tottenham in fifth – who are not playing until Sunday – as they welcome Crystal Palace to the Emirates Stadium.
Leicester have the chance to move into seventh as they welcome Watford to the King Power Stadium.
Stoke and West Brom both have the chance to move out of the bottom three if they can claim three points. Second bottom West Brom face a tough looking trip to Everton, whilst third from bottom Stoke – who have Paul Lambert in charge for the first time – host Huddersfield.
Should Stoke or West Brom claim wins, the team who would drop in, is Southampton – but they would not be able to do anything about it until Sunday when they face Spurs.
Finally, West Ham host Bournemouth – with both teams looking to for the win which could take them into the top-half of the table.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Brighton & Hove Albion 12:30 Chelsea
Live On Sky Sports
TEAM NEWS: Steve Sidwell and Izzy Brown are the only players missing for Brighton – both ruled out for the season. Chelsea have Spanish stars Alvaro Morata and Pedro suspended, whilst they hope that Gary Cahill, Cesc Fabregas and new signing Ross Barkley could all feature.
KEY FACT: Brighton have lost their last seven games against Chelsea in all competition
MATCH ODDS: Brighton 9/2 Draw 11/4 Chelsea 8/13
bet365 Pick: Chelsea to win to Nil @11/8
ANDY SAYS: Has to be an away win, don’t think Chelsea will be denied…0-2
GRAEME SAYS: Brighton will push Chelsea here, but narrow away win…1-2
SILKY SAYS: Comfortable away win, I don’t see Chelsea struggling like they did midweek…0-3
FOOTBALLIndex – One to follow: Just outside the top-50, Ross Barkley is sure to increase once his makes his debut
Arsenal 15:00 Crystal Palace
TEAM NEWS: Arsenal are hoping that Laurent Koscielny, Nacho Monreal, Mesut Ozil and Ainsley Maitland-Niles will all be available but Olivier Giroud and Santi Cazorla remain sidelined. Crystal Palace will welcome back Joel Ward and Yohan Cabaye, but Ruben Loftus-Cheek, Jeffrey Schlupp, Andros Townsend, Mamadou Sakho, Scott Dann and Jason Puncheon are ruled out.
KEY FACT: Arsenal have never failed to score in 17 home league matches against Crystal Palace
MATCH ODDS: Arsenal 1/2 Draw 15/4 Palace 6/1
bet365 Pick: Under 2.5 goals @27/20
ANDY SAYS: I can see my former club claiming a point from this…1-1
GRAEME SAYS: Hard to see Palace getting anything here, and they probably won’t…2-1
SILKY SAYS: Arsenal will have too much for Palace here, home win…3-1
FOOTBALLIndex – One to follow: Wilfried Zaha at £1.79 looks a very good buy
Burnley 15:00 Manchester United
TEAM NEWS: Man Utd have no fresh injury worries but Zlatan Ibrahimovic, Eric Bailly and Michael Carrick remain sidelined. Scott Arfield should return, whilst Chris Wood and Stephen Ward remain major doubts. Robbie Brady and Tom Heaton are out.
KEY FACT: Burnley have won one of their last 24 matches against Manchester United
MATCH ODDS: Burnley 13/2 Draw 29/10 Man Utd 4/7
bet365 Pick: Man Utd to win & Under 2.5 goals @21/10
ANDY SAYS: Hard to see Burnley getting a result, and I think United get the three points…0-2
GRAEME SAYS: Tough game, I can see Burnley holding Jose’s boys…0-0
SILKY SAYS: Has to be United for me, they will get the three points here…0-2
FOOTBALLIndex – One to follow: Marcus Rashford in the top-20, still looks a good deal
Everton 15:00 West Bromwich Albion
TEAM NEWS: New signing Theo Walcott is in-line to make his Everton debut, whilst Michael Keane could return from injury. Ramiro Funes Mori, Leighton Baines and Seamus Coleman are all long-term absentees. James Morrison and Nacer Chadli remain sidelined for West Brom.
KEY FACT: Everton have lost just one of their last 10 Premier League matches with West Brom
MATCH ODDS: Everton 23/20 Draw 11/5 WBA 3/1
bet365 Pick: Both Teams To Score @11/10
ANDY SAYS: Tough call for me here, but I think West Brom might just claim a point…1-1
GRAEME SAYS: I just don’t see how West Brom can win here…3-1
SILKY SAYS: Everton will be too strong for West Brom here, home win…2-0
FOOTBALLIndex – One to follow: Theo Walcott bolstered by move could be a great pick up
Leicester City 15:00 Watford
King Power Stadium
TEAM NEWS: Danny Simpson could be ready to return, but the game will come too soon for Wes Morgan and Robert Huth. Tom Cleverley is a doubt for Watford, with Isaac Success and Craig Cathcart sidelined.
KEY FACT: Leicester have won seven of their last nine home league matches
MATCH ODDS: Leicester 17/20 Draw 29/10 Watford 10/3
bet365 Pick: Under 2.5 goals @6/4
ANDY SAYS: Has to be a home win, Leicester are looking decent…2-0
GRAEME SAYS: Leicester will surely have too much for Watford here…3-1
SILKY SAYS: Close game, two decent teams but I think Leicester will claim the three points…2-1
FOOTBALLIndex – One to follow: In the top-50 at just over £2, Richarlison still a good buy
Stoke City 15:00 Huddersfield Town
TEAM NEWS: New full-back Kostas Stafylidis could be handed his debut, whilst Ryan Shawcross and Glen Johnson will have late fitness tests. Jese is unavailable. Collin Quaner, Chris Lowe and Michael Hefele are all fit to return for Huddersfield, but Philip Billing, Martin Cranie, Elias Kachunga and Jon Stankovic are all out. KEY FACT: This will be Paul Lambert’s first PL match in charge since February 2015
MATCH ODDS: Stoke 21/20 Draw 12/5 Huddersfield 31/10
bet365 Pick: Over 2.5 goals @23/20
ANDY SAYS: Big game for Paul Lambert but I think he can open with a win…1-0
GRAEME SAYS: Have to side with Stoke here, Paul Lambert might kick-start something…2-0
SILKY SAYS: Close game, can see Huddersfield doing enough to earn a point…1-1
FOOTBALLIndex – One to follow: Peter Crouch up to nearly a £1 – could still have something to offer
West Ham United 15:00 AFC Bournemouth
TEAM NEWS: Junior Stanislas and Joshua King are back in contention for Bournemouth but Tyrone Mings and Jermain Defoe are out. Andy Carroll and Winston Reid miss out for West Ham, whilst Javier Hernandez and Cheikhou Kouyate are major doubts.
KEY FACT: West Ham can win back-to-back PL matches for the first time in 364 days
MATCH ODDS: West Ham Evs Draw 13/5 Bournemouth 3/1
bet365 Pick: Both Teams To Score @3/4
ANDY SAYS: I can see Bournemouth getting something from this, at least a point…1-1
GRAEME SAYS: Can only see a West Ham win here, fairly comfortable…2-0
SILKY SAYS: Has to be West Ham here for me, will give it to them with the home advantage…2-1
FOOTBALLIndex – One to follow: Marko Arnautovic remains a good buy for anyone
Manchester City 17:30 Newcastle United
Live On BT Sport
TEAM NEWS: David Silva is set to return for City, but captain Vincent Kompany is a major doubt. Fabian Delph is set to miss out. Dwight Gayle faces a fitness test for Newcastle, whilst Florian Lejeune is a major doubt.
KEY FACT: Manchester City are unbeaten in 20 Premier League matches against Newcastle
MATCH ODDS: Man City 1/8 Draw 9/1 Newcastle 25/1
bet365 Pick: Both Teams To Score @Evens
ANDY SAYS: City even not at their best will win this…2-0
GRAEME SAYS: Man City win, not much else to say on this one…4-0
SILKY SAYS: Comfortable City win, impossible to go with anything else…4-0
FOOTBALLIndex – One to follow: David Silva outside the top-100 is a huge bargain