Manchester United look to close the gap on arch rivals and leaders Manchester City on Sunday.
Second placed United travel to the North East to face Newcastle – who are in desperate need of a win as they are only out of the drop-zone on goal-difference.
Liverpool are looking to move back into third as they travel to St Mary’s to take on Southampton.
The other game is the early kick-off as Huddersfield look to move out of the bottom three as they play host to Bournemouth.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Huddersfield Town 12:00 AFC Bournemouth
John Smith’s Stadium
TEAM NEWS: Danny Williams should be back for Huddersfield, but Tommy Smith is sidelined, whilst Christopher Schindler and Laurent Depoitre are doubts. Jermain Defoe misses out for Bournemouth but Adam Smith and Steve Cook are in contention.
KEY FACT: Town are starting a Premier League match in the relegation zone for the first time
MATCH ODDS: Huddersfield 23/10 Draw 11/5 Bournemouth 29/20
bet365 Pick: Draw @11/5
ANDY SAYS: Tough call and Huddersfield are not playing great so 1-2
GRAEME SAYS: I can see Huddersfield coming back to form and winning this…2-0
SILKY SAYS: I think Bournemouth will claim the three points…1-2
FOOTBALLIndex – One to follow: At £1.24 Aaron Mooy still looks a good buy
Newcastle 14:15 Man Utd
St. James’ Park
TEAM NEWS: Newcastle are waiting on new signing Islam Slimani to see if he can make his debut, but Jesus Gamez remains sidelined. Man United remain without Daley Blind, Eric Bailly, Marouane Fellaini, Zlatan Ibrahimovic.
KEY FACT: Man Utd have won nine of their last 13 PL matches against Newcastle at St. James’ Park
MATCH ODDS: Newcastle 5/1 Draw 29/10 Man Utd 4/6
bet365 Pick: Man Utd @4/6
ANDY SAYS: I think we could see a shock here… 1-0
GRAEME SAYS: I don’t see how Man Utd don’t win this one…0-3
SILKY SAYS: I think Man U will take the the three points home with them…0-2
FOOTBALLIndex – One to follow: Romelu Lukaku is outside the top-ten now so could be worth a go
Southampton 16:30 Liverpool
St. Mary’s Stadium
TEAM NEWS: Southampton are only missing one player with Charlie Austin sidelined. Joe Gomez is sidelined, whilst Ragnar Klavan, Alberto Moreno and Adam Lallana are all possibilities to feature.
KEY FACT: Sadio Mane has scored six goals in his last five Premier League appearances at St. Mary’s.
MATCH ODDS: Southampton 7/2 Draw 3/1 Liverpool 4/5
bet365 Pick: Draw @3/1
ANDY SAYS: Have to go with Liverpool in this one but I think it will be quite close…1-2
GRAEME SAYS: I can see Liverpool taking this quite comfortably…0-3
SILKY SAYS: Has to be a Liverpool win, don’t see Southampton troubling them…0-2
FOOTBALLIndex – One to follow: Sadio Mane at £2.66 is a great buy