Half of the FA Cup quarter-finalists could be decided on Saturday with four games.
The two all Premier League games take place, with Huddersfield hosting Manchester United, whilst West Brom entertain Southampton at The Hawthorns.
The early kick-off looks a fascinating encounter with Carlos Carvahal making a quick return to Hillsborough as he takes his new Swansea side to face his former employers Sheffield Wednesday.
The other clash sees League Two Coventry City travel to the South Coast to face Brighton.
See below for a preview on each game, including predictions from our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Sheffield Wednesday 12:30 Swansea City
TEAM NEWS: January signings Andre Ayew and Andy King are both ineligible to feature for Swansea, whilst Renato Sanches, Angel Rangel, Wilfried Bony and Leroy Fer miss out through injury but Leon Britton could return. For Wednesday Jordan Thorniley, Sean Clare and Jack Stobbs but Ross Wallace could return. KEY FACT: Swansea have only won one of their past nine meetings with Sheffield Wednesday
MATCH ODDS: Sheff Wed 5/2 Draw 12/5 Swansea 5/4
bet365 Pick: Both Teams to Score – No @4/5
GRAEME SAYS: Carlos Carvahal should return to haunt his former club…0-2
Brighton & Hove Albion 15:00 Coventry City
The AMEX Stadium
TEAM NEWS: Record signing Jurgen Locadia is set to make his debut for Brighton, who are only missing Jiri Skalak and Steve Sidwell through injury. Coventry are set to be without Michael Doyle and Jack Grimmer through injury whilst Jordan Maguire-Drew and Kyel Reid are both ineligible.
KEY FACT: Brighton have only won one of their past nine games against Coventry
MATCH ODDS: Brighton 1/3 Draw 17/4 Coventry 11/1
bet365 Pick: Under 2.5 goals @4/5
GRAEME SAYS: Coventry’s run will come to an end here…3-1
West Bromwich Albion 15:00 Southampton
TEAM NEWS: West Brom could hand January loan signing Ali Gabr his debut after securing his work-permit, but Daniel Sturridge remains sidelined. Manolo Gabbiadini and Mario Lamini should feature, whilst Shane Long is due to undergo a fitness test.
KEY FACT: Southampton have won their last three meetings with West Brom
MATCH ODDS: West Brom 19/10 Draw 23/10 Southampton 13/8
bet365 Pick: Both Teams to Score @10/11
GRAEME SAYS: Could see a replay being needed here…1-1
Huddersfield Town 17:30 Manchester United
The John Smith’s Stadium
TEAM NEWS: Huddersfield are without injured midfielder Aaron Mooy, whilst Alex Pritchard is cup-tied. Ander Herrera and Marcus Rashford both miss out for United, whilst Eric Bailly could return after three-months on the sidelines.
KEY FACT: The Terriers haven’t reached the FA Cup quarter-finals since the 1972
MATCH ODDS: Huddersfield 7/1 Draw 15/4 Man Utd 4/9
bet365 Pick: Under 2.5 goals @Evens
GRAEME SAYS: Will be close but United should just have enough to get through…1-2