Liverpool have the chance to move into second place as they are the only side in the top-six in action on Saturday.
The Reds, who start the day in third, will move above Manchester United and into second if they can take all three points from West Ham – who visit Anfield.
Bottom-of-the-table West Brom are looking to end a miserable run of three successive losses as they host Huddersfield, who are just a point above the drop-zone themselves.
Second bottom Stoke have the chance to move out of the relegation places, as they travel to Leicester City in the early kick-off.
Southampton’s poor run has seen them drop into the bottom-three, but they also could move out of the drop-zone but a draw at Burnley will be enough to see them move up the table.
Bournemouth are in tenth, but they remain just five points above the relegation spots and they host Newcastle – who are three points worse off than The Cherries.
Swansea and Brighton both remain firmly entrenched in the relegation battle and the two sides meet at the AMEX Stadium.
The final game of the day sees Watford play host to Everton at Vicarage Road.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Leicester City 12:30 Stoke City
King Power Stadium
TEAM NEWS: Wes Morgan is set to make his Premier League return, whilst Shinji Okazaki is back in training and could be involved. Bruno Martins Indi is available again for Stoke, but Peter Crouch and Stephen Ireland are ruled out.
KEY FACT: Leicester have lost only one of their seven previous Premier League matches against Stoke
MATCH ODDS: Leicester 8/11 Draw 5/2 Stoke 4/1
bet365 Pick: Under 2.5 goals @19/20
ANDY SAYS: Leicester for me, they should be taking the three points…2-0
GRAEME SAYS: Has to be a home win, I think Leicester will be too good…3-1
FOOTBALLIndex – One to follow: At 88p, what a bargain Jamie Vardy is
Bournemouth 15:00 Newcastle
TEAM NEWS: Jermain Defoe and Tyrone Mings miss out for Bournemouth but Dan Gosling could face his former club. Islam Slimani could feature for Newcastle along with Ciaran Clark but Jesus Gamez misses out. KEY FACT: The Cherries are looking to win a fourth consecutive PL home match for the first time
MATCH ODDS: Bournemouth 21/20 Draw 12/5 Newcastle 13/5
bet365 Pick: Matt Ritchie to score anytime @3/1
ANDY SAYS: Close game and I have to think a draw…1-1
GRAEME SAYS: Bournemouth should be winning this but Newcastle might just escape with a point…1-1
FOOTBALLIndex – One to follow: At 61p, Matt Ritchie looks an interesting prospect
Brighton 15:00 Swansea
TEAM NEWS: Brighton only have Steve Sidwell and Jiri Skalak missing for the game. Alfie Mawson is back for Swansea, but Leon Britton, Renato Sanches, Angel Rangel, Wilfried Bony and Leroy Fer are sidelined.
KEY FACT: Brighton’s Chris Hughton has lost only one of his seven previous meetings with Swansea
MATCH ODDS: Brighton 21/20 Draw 9/4 Swansea 14/5
bet365 Pick: Draw @9/4
ANDY SAYS: A big game but I think Swansea can maintain their good run and claim the win…1-2
GRAEME SAYS: I think Brighton will end Swansea’s good run here…2-1
FOOTBALLIndex – One to follow: Jose Izquierdo is available at just 85p – one to watch for sure
Burnley 15:00 Southampton
TEAM NEWS: Burnley could be boosted by the return of Chris Wood, Stephen Ward, Dean Marney, James Tarkowski and Phil Bardsley, but Tom Heaton and Scott Arfield are sidelined. Sofiane Boufal is set to return for Southampton but Maya Yoshida, Shane Long, Steve Davis and Charlie Austin are sidelined.
KEY FACT: Burnley have won three of their five Premier League matches against Southampton
MATCH ODDS: Burnley 9/5 Draw 21/10 Southampton 8/5
bet365 Pick: Draw @21/10
ANDY SAYS: Home win, Burnley should just about grind out a win here…1-0
GRAEME SAYS: Tough game for Southampton, and can’t see Burnley not winning this…2-0
FOOTBALLIndex – One to follow: Oriol Romeu is doing very well in the Index, and is just outside the top-100
Liverpool 15:00 West Ham
TEAM NEWS: West Ham are waiting on Winston Reid who has an illness, whilst Manuel Lanzini could return but Pedro Obiang and Andy Carroll remain sidelined and Arthur Masuaku is suspended. Liverpool have a near fully fit squad to choose from but England full-back Nathaniel Clyne remains out.
KEY FACT: David Moyes has never won against Liverpool at Anfield in any competition as a manager
MATCH ODDS: Liverpool 2/9 Draw 11/2 West Ham 11/1
bet365 Pick: Liverpool to win & Both Team to Score @6/4
GRAEME SAYS: Comfortable home win, little doubt for me that Liverpool will be too good…3-1
FOOTBALLIndex – One to follow: Sadio Mane in the top-30 – he should be higher
West Brom 15:00 Huddersfield
TEAM NEWS: Daniel Sturridge, Nacer Chadli and James Morrison are out for West Brom, but England internationals Kieran Gibbs and Jake Livermore return. Laurent Depoitre, Chris Lowe and Aaron Mooy could feature but Elias Kachunga is sidelined.
KEY FACT: Huddersfield have faced three teams this season who started the day in the relegation zone and have lost all three matches 2-0
MATCH ODDS: West Brom 10/11 Draw 9/4 Huddersfield 10/3
bet365 Pick: Over 2.5 goals @7/5
ANDY SAYS: I don’t see Huddersfield getting anything here, comfortable home win…2-0
GRAEME SAYS: If West Brom are going to get a win, they will get it here and they should…2-1
FOOTBALLIndex – One to follow: Aaron Mooy is still just in the top-100 but worth a look
Watford 17:30 Everton
TEAM NEWS: Younes Kaboul, Christian Kabasele, Tom Cleverley and Nathaniel Chalobah are all sidelined but Heurelho Gomes, Miguel Britos, Will Hughes and Kiko Femenia could return. For Everton Maarten Stekelenburg, Leighton Baines and James McCarthy all still out
KEY FACT: Everton have won only one of their last 21 PL away matches
MATCH ODDS: Watford 23/20 Draw 9/4 Everton 12/5
bet365 Pick: Gerard Deulofeu to score anytime @11/4
ANDY SAYS: I can see Watford just about claiming the win, will be a close affair…1-0
GRAEME SAYS: A close call, but think Watford might just edge it…2-1
FOOTBALLIndex – One to follow: Abdoulaye Doucoure at just over £1 looks a great prospect