Three teams on Saturday go into action looking to maintain their winning starts to the new season.
Chelsea, Tottenham and Bournemouth all recorded three points on the opening weekend.
New Chelsea boss Maurizio Sarri takes charge of his first home game as they host capital rivals Arsenal, whose boss Unai Emery goes in search of his first point after opening with defeat to champions Manchester City.
Tottenham sealed victory at Newcastle in their opener, and they host Fulham at Wembley looking for back-to-back wins in the opener.
Bournemouth look for six points with a trip to West Ham – who are looking to bounce back from their mauling at the hands of Liverpool in their opening clash.
The opening game of the weekend sees newly promoted Cardiff open their home campaign by hosting Newcastle at lunch-time – both lost last week.
Marco Silva’s first game at Goodison Park sees The Toffees take on Southampton, whilst the other game on Saturday sees Leicester host Midlands rivals Wolves.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Cardiff City 12:30 Newcastle United
Cardiff City Stadium
TEAM NEWS: Cardiff are waiting to hear on the fitness of Kenneth Zohore who has been suffering with a groin problem, but he could make it and may start.
DeAndre Yedlin is a doubt for Newcastle with a knee injury so Javier Manquillo may come in for a rare start.
KEY FACT: Newcastle have won their last 10 league meetings with Cardiff
MATCH ODDS: Cardiff 9/4 Draw 21/10 Newcastle 31/20
bet365 Pick: Both Teams Not To Score @7/10
ANDY SAYS: Nothing Cardiff did over the summer convinced me and they are in for a long hard season, including losing to Newcastle here…0-2
GRAEME SAYS: Newcastle looked okay in their opener but there is more to come from Cardiff and I see them claiming victory here as Neil Warnock will get a performance…2-1
FOOTBALLIndex – One to follow: Jonjo Shelvey – he thinks he is the man, well if he proves it then he is very much one to watch
Everton 15:00 Southampton
TEAM NEWS: Richarlison will be fit, despite suffering cramp on his debut. Phil Jagielka is suspended but could be replaced by new signing Kurt Zouma, but fellow new boys Yerry Mina and Andre Gomes are not available.
Danny Ings looks set to make his first start for Southampton, whilst Stuart Armstrong is set to make the match but Mohamed Elyounoussi is a doubt.
KEY FACT: Everton are unbeaten in their last 13 home league matches against Southampton
MATCH ODDS: Everton 10/11 Draw 5/2 Southampton 15/4
bet365 Pick: Both Teams Not To Score @4/5
ANDY SAYS: Everton made some good additions, they need to win this and I don’t see them not landing the three points here…2-0
GRAEME SAYS: Everton looked good against Wolves, and whilst Southampton may put up some defence – I don’t see them preventing a home win…3-1
FOOTBALLIndex – One to follow: Richarlison – great debut, and there is surely more to come from Everton’s record signing
Leicester City 15:00 Wolverhampton Wanderers
King Power Stadium
TEAM NEWS: Caglar Soyuncu won’t be considered for his debut due to fitness concerns, whilst Matty James and Shinji Okazaki are ruled out.
KEY FACT: All of Ruben Neves’s seven league goals since the start of last season have come from outside the box
MATCH ODDS: Leicester 21/20 Draw 5/2 Wolves 29/10
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: Tough game to pick here, but a good one none-the-less, I think Wolves claim another point…1-1
GRAEME SAYS: A good game, and it is one that I think Leicester need to win and I think they might just sneak it but it will be close…2-1
FOOTBALLIndex – One to follow: Ruben Neves – enjoyed a good opening, what is not to like about the young Portuguese?
Tottenham Hotspur 15:00 Fulham
TEAM NEWS: Erik Lamela, Harry Winks and Josh Onomah are all back in training and may push for places on the bench. Son Heung-min is away with South Korea at the Asian Games.
Fulham are without injured defenders Tim Ream and Alfie Mawson, whilst Denis Odoi is suspended. Joe Bryan is a doubt with an ankle problem.
KEY FACT: Harry Kane is still seeking his first ever Premier League goal in August
MATCH ODDS: Spurs 2/7 Draw 5/1 Fulham 11/1
bet365 Pick: Fulham plus two goals @Evens
ANDY SAYS: I don’t see a big issue for my former club here, I think they open up their new home campaign with a comfortable win…3-0
GRAEME SAYS: Tough call, depends which Fulham turn up but I think they might just give Tottenhma a bit of a shock here…1-1
FOOTBALLIndex – One to follow: Ryan Sessegnon – one of the best young players in Europe, a no brainer.
West Ham United 15:00 AFC Bournemouth
TEAM NEWS: West Ham could give debuts to Lucas Perez and Carlos Sanchez, but are still without Manuel Lanzini, Winston Reid and Andy Carroll.
Bournemouth could hand record signing Jefferson Lerma his debut in midfielder, but fellow new boy Diego Rico is still suspended. Junior Stanislas is still injured.
KEY FACT: West Ham and Bournemouth have two wins apiece and two draws in their six Premier League meetings
MATCH ODDS: West Ham 21/20 Draw 13/5 Bournemouth 14/5
bet365 Pick: Over 2.5 goals @4/5
ANDY SAYS: I am not sure about West Ham at the moment, they were poor against Liverpool and I can see Bournemouth getting something…1-2
GRAEME SAYS: I don’t put too much stock into West Ham’s loss at Liverpool, and I think they bounce back here with victory…2-0
FOOTBALLIndex – One to follow: Jack Wilshere – if he can live up to the billing, he could be a sensational pick up on the Index
Chelsea 17:30 Arsenal
TEAM NEWS: Chelsea are set to start Eden Hazard after he came off the bench against Huddersfield. Cesc Fabregas remains sidelined.
Nacho Monreal is set to return, and looks to replace Ainsley Maitland-Niles, who has fractured his fibula. Sead Kolasinac and Carl Jenkinson are still sidelined.
KEY FACT: Chelsea have won five of their last six home Premier League matches against Arsenal
MATCH ODDS: Chelsea 4/5 Draw 3/1 Arsenal 7/2
bet365 Pick: Chelsea to win & Both Teams To Score @12/5
ANDY SAYS: Chelsea were good opening day, Arsenal wern’t – will that change? No. Chelsea are going to win here and without too much trouble…2-0
GRAEME SAYS: A good game coming, but I don’t see Arsenal suddenly coming to form here – home win, and by some…3-0
FOOTBALLIndex – One to follow: Eden Hazard – lots of new names, come about – but Hazard is still as good as they get in the Premier League and the Index.