Manchester City, the favourites to win the Champions League this season, get their campaign underway as they host Lyon.
Pep Guardiola’s men are predicted to give him his first European title since 2011, and he is hopeful they can start in impressive fashion in Group F – but he admits they need to start living up to their favourite tags.
“We can talk about deserving credit or being favourites but what matters is on the pitch. It’s Tuesday and Wednesday games: show me the money, guys,” said Guardiola.
Manchester United are also in action as they travel to Young Boys in Switzerland.
Despite facing one of the minnows of the whole tournament, Jose Mourinho is not expecting an easy match.
“Young Boys is, of course, a team that comes from the fourth pot and the world will say it’s the team that didn’t have a chance to qualify but for some reason they qualified,” he said.
“They went to Croatia and won in the play-offs [against Dinamo Zagreb], for some reason they beat Basel and they won the Swiss title.
“On top of that, they play on an artificial pitch, which is a big advantage for them and a big disadvantage for the other teams.”
Also in action on Wednesday are Juventus, Bayern Munich and current holders Real Madrid.
We run through every game including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, our own Football Insider Graeme Bailey and BoyleSports’ Lawrence Lyons.
Ajax 17:55 AEK Athens
MATCH ODDS: Ajax 4/11 Draw 7/2 AEK 8/1
BoyleSports pick: Huntelaar to score and Ajax to win @5/4
ANDY SAYS: Has to be a home win, don’t see AEK getting anything from this trip…3-1
GRAEME SAYS: I often think Ajax flatter to deceive, this is a must win and I give them the benefit of the doubt…2-0
Football Index – One to follow: Frenkie De Jong – real up and coming talent, one to keep an eye on
Benfica 20:00 Bayern Munich
MATCH ODDS: Benfica 5/1 Draw 16/5 Bayern 1/2
BoyleSports pick: Draw Half Time/ Bayern Full Time @16/5
ANDY SAYS: Bayern are a class act, and Benfica just aren’t as strong as they once were – comfortable away win coming…1-4
GRAEME SAYS: Never an easy game and am not sure Bayern will find it that easy, but little doubt they will pick up three points here…0-2
Football Index – One to follow: Corentin Tolisso – outstanding French midfielder, looks very good value on the Index
Shakhtar Donetsk 17:55 1899 Hoffenheim
MATCH ODDS: Shakhtar 20/21 Draw 13/5 Hoffenheim 13/5
BoyleSports pick: Shakhtar to win to nil @14/5
ANDY SAYS: Tough call this one, Shakhtar are not as good as they were so I think Hoffenheim can get something here…1-1
GRAEME SAYS: Going to Ukraine is never easy and I don’t think Hoffenheim are good enough to get something…3-1
Football Index – One to follow: Wellington Nem – one of the many Brazilians for Shakhtar, outstanding player who is very much one to keep an eye on
Manchester City 20:00 Lyon
MATCH ODDS: Man City 2/11 Draw 6/1 Lyon 12/1
BoyleSports pick: Man City to win both halves @5/4
ANDY SAYS: Home win, no doubt – Man City can win the whole thing and Lyon won’t be able to stop them…4-0
GRAEME SAYS: Lyon could be difficult in this group, but this game is one which they will have to forget quickly…5-0
Football Index – One to follow: Raheem Sterling – still not getting the praise he deserves and still a bargain on the Index
Real Madrid 20:00 Roma
MATCH ODDS: Real 1/3 Draw 4/1 Roma 15/2
BoyleSports pick: Real to win & Both Teams To Score @11/8
ANDY SAYS: I am not convinced by Real this season and I don’t see them winning this again and I think Roma take something off them here…2-2
GRAEME SAYS: Real should not be under-estimated, people think without Ronaldo they are not the same – but they will show here that they are still a force to be reckoned with…3-1
Football Index – One to follow: Gareth Bale – he will step up and become a world great with Ronaldo gone, he is one you should have in your portfolio
Viktoria Plzen 20:00 CSKA Moscow
MATCH ODDS: Plzen 13/10 Draw 21/10 CSKA 23/10
BoyleSports pick: Draw @21/10
ANDY SAYS: Don’t see many goals and there won’t be too much in it but I think CSKA will come away with a point…1-1
GRAEME SAYS: CSKA have good pedigree and think they will have enough to claim the win here…1-2
Football Index – One to follow: Alan Dzagoev – has been around a long-time but there is still some value to be had here
Valencia 20:00 Juventus
MATCH ODDS: Valencia 10/3 Draw 5/2 Juventus 5/6
BoyleSports pick: Ronaldo to score & Juventus to win @13/8
ANDY SAYS: Has to be Juventus here, they are a great team and I can see them dominating this group…1-3
GRAEME SAYS: Far from easy in Spain for Juve, but I think they are just too good not to take the win…2-3
Football Index – One to follow: Miralem Pjanic – a wonderful player, who should be followed by anyone
Young Boys 20:00 Manchester United
MATCH ODDS: Young Boys 4/1 Draw 11/4 Man Utd 7/10
BoyleSports pick: Lukaku to score 2 or more @6/1
ANDY SAYS: I can see United winning here, they have shown some real form in recent weeks and have responded to a bad start, so away win…1-2
GRAEME SAYS: United need to win this and I think they just about will but won’t be easy…0-1
Football Index – One to follow: Romelu Lukaku – well worth investment, in form and can surely only go one way