Tuesday’s sees the first games of a full midweek schedule, with four games including leaders Manchester City.
City have a chance to go five points clear at the top of the table, as they did at the weekend before being pegged back by Liverpool the following day – and the same is true this midweek.
Unbeaten City face a tricky looking contest as they travel to Vicrage Road to take on Watford.
There is a huge game on the South Coast, with Brighton hosting arch-rivals Crystal Palace – both coming off the back of victories at the weekend.
West Ham and Cardiff also go into their match off the back of three points, as they meet at the London Stadium.
Bournemouth could move up to sixth with victory at the Vitality Stadium as they host Huddersfield Town.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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AFC Bournemouth 19:45 Huddersfield Town
TEAM NEWS: Jefferson Lerma returns form suspension for Bournemouth, but they are without Dan Gosling and Adam Smith.
Steve Mounie is suspended for Huddersfield, whilst Chris Lowe remains sidelined but Alex Pritchard could feature.
KEY FACT: Bournemouth are unbeaten in six home matches against Huddersfield
MATCH ODDS: Bournemouth 7/10 Draw 29/10 Huddersfield 9/2
bet365 Pick: Under 2.5 goals @10/11
ANDY SAYS: Looking at a home win here, but won’t be easy…2-1
GRAEME SAYS: Bournemouth will get the three points here, I don’t see Huddersfield travelling too well…2-0
Football Index – One to follow: Callum Wilson – new England cap, is really on the up and is one who should be followed
Brighton & Hove Albion 19:45 Crystal Palace
TEAM NEWS: Alireza Jahanbakhsh is the only injured player for Brighton with captain Bruno ready to return. Dale Stephens is suspended.
Palace are without strikers Christian Benteke and Connor Wickham, and also Scott Dann.
KEY FACT: Brighton have not won any of their six midweek Premier League matches
MATCH ODDS: Brighton 15/8 Draw 21/10 Crystal Palace 9/5
bet365 Pick: Both Teams To Score @21/20
ANDY SAYS: A cracking game, and I see Palace getting something from the game…1-1
GRAEME SAYS: I can see Glenn Murray haunting his old club and winning this for Brighton…2-1
Football Index – One to follow: Max Meyer – could he be a hidden gem for Palace and on the Index?
West Ham United 19:45 Cardiff City
TEAM NEWS: West Ham hope to have Aaron Cresswell and Fabian Balbuena available, but Andriy Yarmolenko, Carlos Sanchez, Winston Reid, Manuel Lanzini and Ryan Fredericks are all injured.
Jazz Richards, Greg Cunningham, Joe Bennett and Kenneth Zohore are all expected to miss out but Nathaniel Mendez-Laing could make his his return.
KEY FACT: West Ham have won their last six matches in all competitions against Cardiff
MATCH ODDS: West Ham 4/6 Draw 3/1 Cardiff 19/4
bet365 Pick: Under 2.5 goals @Evens
ANDY SAYS: Home win, West Ham were good at Newcastle so they should have too much…2-0
GRAEME SAYS: Have to with West Ham making it back to back wins, and could be a comfortable one…3-0
Football Index – One to follow: Marko Arnautovic – could be set for a big money, really one to be on
Watford 20:00 Manchester City
TEAM NEWS: Watford have the luxury of a near fully fit squad to choose from with only recent addition Adalberto Penaranda ruled out.
Kevin De Bruyne, Benjamin Mendy, Eliaquim Mangala and Claudio Bravo are all out for City, whilst Sergio Aguero and Oleksandr Zinchenko could also miss out.
KEY FACT:Watford are winless in their eight Premier League meetings with Man City
MATCH ODDS: Watford 10/1 Draw 5/1 Man City 3/10
bet365 Pick: Man City Win & Under 3.5 goals @13/8
ANDY SAYS: Comfortable home win, you have to go with City…0-3
GRAEME SAYS: Not sure City will have this their own way, but they still win…1-2
Football Index – One to follow: Raheem Sterling – such a good player, still on the up