Liverpool look to keep pace with leaders Manchester City on Wednesday.
Jurgen Klopp’s men are still unbeaten in the Premier League and they will look to continue that form as they travel across Lancashire to face second from bottom Burnley.
The game of this midweek, though, is surely at Old Trafford as in-form Arsenal could rise to third with victory over out-of-sorts Manchester United.
To go into third, Arsenal would also need Chelsea not to win – and they face a trip to Wolves, who have lost five of their last six league games.
Tottenham are looking to bounce back from their weekend loss in the North London derby as they host manager-less Southampton at Wembley.
Everton moved into sixth at the weekend and they will remain with victory over Newcastle at Goodison.
The final game of the evening travel to Craven Cottage to face Fulham.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Burnley 19:45 Liverpool
TEAM NEWS: Stephen Ward and Nick Pope remain sidelined for Burnley, but Belgian star Steven Defour could be available.
Liverpool hope that Andrew Robertson and Sadio Mane make the game, but Alex Oxlade-Chamberlain, Adam Lallana and Dominic Solanke are all out.
KEY FACT: All seven of Liverpool’s PL goals at Turf Moor have come in the second half
MATCH ODDS: Burnley 13/1 Draw 19/4 Liverpool 2/7
bet365 Pick: Under 2.5 goals @13/10
ANDY SAYS: Tough trip for Liverpool here, but they will surely have more than enough to win…1-2
GRAEME SAYS: Burnley are not playing very well at all – Liverpool win, no doubt…0-2
Football Index – One to follow: Joe Gomez – is not many better young defenders in world football, certainly one to watch
Everton 19:45 Newcastle United
TEAM NEWS: Everton could have a full fit squad to choose from if Morgan Schneiderlin overcomes a leg injury.
Matt Ritchie is suspended for Newcastle who are already without Paul Dummett, Isaac Hayden, Karl Darlow and Florian Lejeune.
KEY FACT: Newcastle haven not won a midweek Premier League match since December 2013
MATCH ODDS: Everton 8/15 Draw 16/5 Newcastle 13/2
bet365 Pick: Under 2.5 goals @10/11
ANDY SAYS: Comfortable home win coming for Everton, I don’t see Newcastle getting anything here…2-0
GRAEME SAYS: I don’t think it is beyond doubt that Newcastle get something here…2-2
Football Index – One to follow: Richarlison – what a season he has had, certainly one to invest in
Fulham 19:45 Leicester City
TEAM NEWS: Andre Zambo Anguissa and Andre Schurrle could return for Fulham but Floyd Ayite and Kevin McDonald are sidelined.
Leicester are hoping that Jamie Vardy, Harry Maguire and Rachid Ghezzal could feature but they are all rated as doubtful.
KEY FACT: Leicester City have failed to score in all four Premier League meetings with Fulham
MATCH ODDS: Fulham 2/1 Draw 5/2 Leicester 29/20
bet365 Pick: Both Teams To Score & Over 2.5 goals @21/20
ANDY SAYS: I think Leicester take something here but Ranieri has improved Fulham, so draw for me…2-2
GRAEME SAYS: Depends on Leicester’s injuries so will go with a point for Fulham…1-1
Football Index – One to follow: Ryan Sessegnon – a true star for the future, worth investing in
Wolverhampton Wanderers 19:45 Chelsea
TEAM NEWS: Jonny Castro is the only injury for Wolves, but Ruben Neves is suspended for Nuno’s side.
Marcos Alonso and Mateo Kovacic are expected to be fit for Chelsea, but Ross Barkley and Victor Moses look set to be ruled out.
KEY FACT: Wolves have lost seven of their eight Premier League matches against Chelsea
MATCH ODDS: Wolves 4/1 Draw 11/4 Chelsea 4/5
bet365 Pick: Wolves Double Chance @Evens
ANDY SAYS: Really tough game for Chelsea here, but think they will land the win…1-2
GRAEME SAYS: Wolves have been struggling but I think they could cause a bit of a shock and win this…2-0
Football Index – One to follow: Mateo Kovacic – has been very good for Chelsea and well worth a look
Manchester United 20:00 Arsenal
TEAM NEWS: Alexis Sanchez and Victor Lindelof are sidelined for United, and they will also have to wait on Luke Shaw, Chris Smalling, Eric Bailly, Antonio Valencia and Matteo Darmian.
Arsenal are without the suspended Granit Xhaka, whilst Danny Welbeck and Dinos Mavropanos are out – and they will also assess Mesut Ozil, Nacho Monreal and Laurent Koscielny.
KEY FACT: Man Utd are unbeaten in their last 11 Premier League home matches against Arsenal
MATCH ODDS: Man Utd 29/20 Draw 5/2 Arsenal 2/1
bet365 Pick: Under 2.5 goals @11/8
ANDY SAYS: Arsenal win coming up here, not impressed by United at the moment…1-3
GRAEME SAYS: Tough call here, not sure United can be as bad as they have been – so will go draw…2-2
Football Index – One to follow: Pierre-Emerick Aubameyang – has been in great form and certainly has to be looked at
Tottenham Hotspur 20:00 Southampton
TEAM NEWS: Kieran Trippier is back for Tottenham, whilst Erik Lamela remains a doubt. Mousa Dembele, Davinson Sanchez and Victor Wanyama are sidelined, whilst Jan Vertonghen is suspended.
Mario Lemina is suspended for Southampton, but they hope Ryan Bertrand, Matt Targett and Danny Ings are being assessed.
KEY FACT: Spurs have won eight of their last 10 Premier League home matches against Southampton
MATCH ODDS: Spurs 4/11 Draw 17/4 Southampton 17/2
bet365 Pick: Draw @17/4
ANDY SAYS: Comfortable home win coming for my former team here…4-0
GRAEME SAYS: Tottenham are going to win, little doubt about it…2-0
Football Index – One to follow: Harry Kane – he will start on another run soon and so value is still there