Saturday’s Premier League programme is a packed one with eight games and all of the top-seven are in action.
The undoubted game of the weekend comes at Stamford Bridge as fourth-placed Chelsea host league leaders and undefeated Manchester City.
Liverpool, though, do have chance to take over at the top – albeit possibly only for a few hours, as they travel to Bournemouth in the day’s early game.
Tottenham in third face a trip to Leicester in the late game on Saturday evening, whilst rivals Arsenal host Huddersfield at the Emirates.
Bottom of the table Fulham face a trip to Old Trafford and will be looking to inflict more pain on Jose Mourinho’s out-of-sorts Manchester United.
New Southampton boss Ralph Hasenhuttl takes charge of his first game as they travel to the Welsh capital to face Cardiff City.
West Ham host Crystal Palace in a capital derby clash at the London Stadium, whilst second from bottom Burnley welcome Brighton to Turf Moor.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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AFC Bournemouth 12:30 Liverpool
TEAM NEWS: Lewis Cook has been sidelined for up to nine months with a knee ligament injury – meaning he won’t play again this season. Dan Gosling and Adam Smith remain sidelined.
Joe Gomez has joined Alex Oxlade-Chamberlain as a long-term injury victim. Sadio Mane also looks set to miss out along with Dominic Solanke. Andrew Robertson, Dejan Lovren and Nathaniel Clyne could all feature.
KEY FACT: Liverpool have triumphed in four of their six Premier League matches against Bournemouth
MATCH ODDS: Bournemouth 9/2 Draw 16/5 Liverpool 4/7
bet365 Pick: Under 2.5 goals @13/10
ANDY SAYS: Liverpool are showing some real fighting spirit in recent weeks, and they will again here…1-3
GRAEME SAYS: Bournemouth have it in them to get something, and I think they just get a draw…1-1
Football Index – One to follow: Callum Wilson – new England cap, is really on the up and is one who should be followed
Arsenal 15:00 Huddersfield Town
TEAM NEWS: Steve Mounie and Philip Biling are suspended for Town. Chris Lowe and Terence Kongolo could both return for Huddersfield, but Adbelhamid Sabiri is injured.
Arsenal hope Aaron Ramsey and Mesut Ozil will both be available. Danny Welbeck and Rob Holding have joined Nacho Monreal and Konstantinos Mavropanos on the sidelines.
KEY FACT: The Gunners have won 16 of their last 17 PL matches at 3pm on a Saturday
MATCH ODDS: Arsenal 2/7 Draw 5/1 Huddersfield 11/1
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: Arsenal are going to blow Huddersfield away, easy win…4-0
GRAEME SAYS: Home win, it could be a long, long day for Huddersfield…6-0
Football Index – One to follow: Alex Iwobi – he is one player coming on leaps and bounds under Unai Emery, one to watch
Burnley 15:00 Brighton & Hove Albion
TEAM NEWS: Shane Duffy is suspended and Alireza Jahanbakhsh is ruled out, but they hope that Glenn Murray, Jose Izquierdo and Bruno will be back.
Nick Pope remains sidelined, but Steven Defour and Stephen Ward could feature.
KEY FACT: The last five league meetings between Burnley and Brighton have ended as draws
MATCH ODDS: Burnley 19/10 Draw 11/5 Brighton 7/4
bet365 Pick: Burnley @19/10
ANDY SAYS: I think Brighton win this, they are performing at a high level at the moment…1-2
GRAEME SAYS: Burnley played well in midweek and I can see them stepping up an getting the win they need…2-0
Football Index – One to follow: James Tarkowski – England defender, could move to a bigger club, worth considering
Cardiff City 15:00 Southampton
Cardiff City Stadium
TEAM NEWS: Southampton look set to be without Michael Obafemi, Ryan Bertrand, Danny Ings and Shane Long.
Greg Cunningham should return for Cardiff but Jazz Richards and Kenneth Zohore remain sidelined.
KEY FACT:Neil Warnock has lost his last three league matches against Southampton
MATCH ODDS: Cardiff 19/10 Draw 9/4 Southampton 17/10
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: Southampton are poor so can see Cardiff having the edge…2-1
GRAEME SAYS: Cardiff are playing well, have to go with them getting the win…2-0
Football Index – One to follow: Junior Hoilett – in great form, could be worth picking up
Manchester United 15:00 Fulham
TEAM NEWS: Floyd Ayite and Kevin McDonald are both missing for Fulham.
United hope Anthony Martial, Luke Shaw and Phil Jones could all make the match but Alexis Sanchez, Antonio Valencia and Victor Lindelof are ruled out.
KEY FACT: Fulham are winless in 10 Premier League away matches and have lost their last six in-a-row
MATCH ODDS: Man Utd 1/3 Draw 19/4 Fulham 9/1
bet365 Pick: Man Utd to win & Both Teams To Score @13/8
ANDY SAYS: Has to be United here, they battled hard last time out and will have too much for Fulham…2-0
GRAEME SAYS: United should win here, Fulham won’t be easy but they probably don’t have enough…2-0
Football Index – One to follow: Aleksandar Mitrovic – he could become a huge star, and buying him could be a real bargain
West Ham United 15:00 Crystal Palace
TEAM NEWS: Aaron Cresswell and Jack Wilshere could be involved, but West Ham have suffered with the news that Marko Arnautovic has joined their lengthy injury list which already includes Ryan Fredericks, Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini.
Connor Wickham, Scott Dann and Christian Benteke all remain sidelined for Palace.
KEY FACT: West Ham are unbeaten in their last six Premier League matches against Crystal Palace
MATCH ODDS: West Ham 13/10 Draw 12/5 Palace 12/5
bet365 Pick: Draw @12/5
ANDY SAYS: I think Palace can go here and get something from West Ham, should be a good game…1-1
GRAEME SAYS: I firmly believe West Ham get the win here, should be too good for West Ham…2-0
Football Index – One to follow: Jack Wilshere – could be an interesting prospect if he can get back to England type form
Chelsea 17:30 Manchester City
TEAM NEWS: Chelsea have a near fully fit squad to choose from, with Ross Barkley their only major doubt.
Sergio Aguero and Vincent Kompany should be available for City, who remain without the likes of Kevin De Bruyne, Claudio Bravo, Benjamin Mendy and Eliaquim Mangala.
KEY FACT:Man City have a chance to secure a second successive top-flight victory at Chelsea for the first time since January 1955
MATCH ODDS: Chelsea 3/1 Draw 14/5 Man City 19/20
bet365 Pick: Under 2.5 goals @6/5
ANDY SAYS: I can’t go against City, I just believe they are too good…1-3
GRAEME SAYS: City’s unbeaten record is at risk here, I think Chelsea could do something here…2-1
Football Index – One to follow: Eden Hazard – whilst he isn’t number one, there is value in the brilliant Belgian
Leicester City 19:45 Tottenham Hotspur
King Power Stadium
TEAM NEWS: Jonny Evans is suspended for Leicester. Daniel Amartey and Matty James are sidelined, but they are hoping Jamie Vardy, Harry Maguire and Racid Ghezzal could all feature.
Tottenham are without a number of players including Kieran Trippier, Erik Lamela, Vincent Wanyama, Davinson Sanchez, Mousa Dembele and Vincent Janssen.
KEY FACT: Harry Kane has scored 13 goals in 11 appearances against Leicester in all competitions
MATCH ODDS: Leicester 14/5 Draw 11/4 Spurs Evens
bet365 Pick: Spurs to win @Evens
ANDY SAYS: Tough game here for my former club but I think Spurs just win it…1-2
GRAEME SAYS: Close game but should be a good one – I think that Leicester get a point…1-1
Football Index – One to follow: Dele Alli – a sensational talent, plenty of value left in him