Liverpool look to go seven points clear at the top of the Premier League on Saturday.
The Reds lost their unbeaten start to the season last time out when losing to champions Manchester City, and they will be looking to get back to winning ways at Brighton.
Chelsea have the chance to close to within one point of Tottenham in third if they can overcome Newcastle in the day’s late kick-off.
The opening fixture of the day sees Arsenal travel to West Ham United in what looks an interesting capital derby clash.
Every game is massive for bottom-of-the-table Huddersfield who are in desperate need of a win, as they are some eight points off safety, but they could close that gap as they travel to fourth-from-bottom Cardiff City.
Elsewhere at the wrong end, second from bottom Fulham travel to Burnley in what can easily be described as a ‘six-pointer’.
Southampton, who occupy the third relegation place could climb out of the drop-zone with victory, but they have a far from easy task at Leicester.
If Leicester fail to win, then Watford have a chance to replace them in 7th, as they travel to South London to face Crystal Palace.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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West Ham United 12:30 Arsenal
TEAM NEWS: Samir Nasri is in-line to make his West Ham debut against one of his former clubs – having joined at the start of this month.
Marko Arnautovic will feature despite his knock but Ryan Fredericks, Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini all remain sidelined.
Arsenal should welcome back Laurent Kosciely, Hector Bellerin, Shkodran Mustafi and Nacho Monreal. Danny Welbeck, Rob Holding and Henrikh Mkhitaryan are sidelined.
KEY FACT: West Ham have won just one of their last 21 Premier League matches against Arsenal
MATCH ODDS: West Ham 13/5 Draw 14/5 Arsenal 21/20
bet365 Pick: Both Teams To Score & Over 2.5 goals @8/11
ANDY SAYS: I think Arsenal will be far too good for West Ham, and they win this with something to spare…1-3
GRAEME SAYS: I can see West Ham getting something here, should be a decent game but will say a draw…2-2
Football Index – One to follow: Pierre-Emerick Aubameyang – few better in the Premier League at the moment, well worth looking at
Brighton & Hove Albion 15:00 Liverpool
TEAM NEWS: Bernardo and Jose Izquierdo are both sidelined for Brighton. Alireza Jahanbakhsh is on international duty at the Asia Cup.
Virgil van Dijk and Jordan Henderson are both expected to feature, but Dejan Lovren has joined Joel Matip and Joe Gomez on the sidelines. Alex Oxlade-Chamberlain and Adam Lallana are both training, but won’t be available.
KEY FACT: Liverpool are unbeaten at Brighton in the top flight
MATCH ODDS: Brigton 10/1 Draw 5/1 Liverpool 3/10
bet365 Pick: Under 2.5 goals @6/5
ANDY SAYS: Nothing but a Liverpool win coming here, little doubt about it…1-3
GRAEME SAYS: I think Brighton will give Liverpool a game, but it will be an away win…0-2
Football Index – One to follow: Andrew Robertson – arguably the best left-back in the Premier League, worth investing in
Burnley 15:00 Fulham
TEAM NEWS: Aaron Lennon is sidelined for Burnley, but they hope Phil Bardsley, Matt Lowton and Johan Gudmundsson return to fitness. Robbie Brady is suspended.
Alfie Mawson is sidelined but Fulham could welcome back Neeskens Kabano and Andre-Frank Zambo Anguissa.
KEY FACT: Burnley are unbeaten in their last 29 home matches against Fulham in all competitions – stretching back to 1951
MATCH ODDS: Burnley 7/5 Draw 9/4 Fulham 23/10
bet365 Pick: Burnley to win @7/5
ANDY SAYS: A huge game for sure but I think Burnley will edge it…2-1
GRAEME SAYS: I am just not convinced Fulham can get something, has to be a home win…2-0
Football Index – One to follow: Ryan Sessegnon – a huge prospect, well worth investing in
Cardiff City 15:00 Huddersfield Town
Cardiff City Stadium
TEAM NEWS: Kadeem Harris, Danny Ward, Kenneth Zohore and Jazz Richards are all sidelined, but Victor Camarasa and Harry Arter should feature.
Tommy Smith could feature for Huddersfield Town, but Abdelhamid Sabiri, Aaron Mooy and Danny Williams are all out.
KEY FACT: Cardiff are unbeaten in their last 10 matches against Huddersfield
MATCH ODDS: Cardiff 13/10 Draw 11/5 Huddersfield 13/5
bet365 Pick: Over 2.5 goals @6/4
ANDY SAYS: Close game for sure and can see it ending all square…1-1
GRAEME SAYS: Has to be home win for me, Cardiff will be too good…2-0
Football Index – One to follow: Alex Pritchard – well worth consideration, could return to a bigger club
Crystal Palace 15:00 Watford
TEAM NEWS: Watford are set to welcome back Andre Gray and Christian Kabasele, meaning the only absentee is Sebastian Prodl.
Pape Souare has joined Christian Benteke on the sidelines, but they are the only players not available to Roy Hodgson.
KEY FACT: Palace have won five of their last seven home league matches against Watford
MATCH ODDS: Palace 5/4 Draw 12/5 Watford 5/2
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: Not sure Palace have what it takes for the win, but my former club should get something…1-1
GRAEME SAYS: Hard one to predict, but am siding with Watford here…1-2
Football Index – One to follow: Andre Gray – could yet prove a very astute pick-up
Leicester City 15:00 Southampton
King Power Stadium
TEAM NEWS: Daniel Amartey is sidelined for Leicester, but that aside Claude Puel has a fully fit squad to choose from.
Stuart Armstrong and Mario Lemina could return for Southampton, but Danny Ings, Ryan Bertrand and Michael Obafemi are set to miss out. Charlie Austin is serving a suspension.
KEY FACT: Leicester have lost just one of their 12 Premier League home matches against Southampton
MATCH ODDS: Leicester 19/20 Draw 5/2 Southampton 10/3
bet365 Pick: Southampton Double Chance @10/11
ANDY SAYS: Leicester will be too good for Southampton here, little doubt…2-0
GRAEME SAYS: Being at home, you have to go with Leicester…3-1
Football Index – One to follow: James Maddison – really is one to watch
Chelsea 17:30 Newcastle United
TEAM NEWS: Ruben Loftus-Cheek is sidelined for Chelsea, but Alvaro Morata could feature in what could be his last game for the club.
Jonjo Shelvey and Momo Diame are doubts for Newcastle, whilst Karl Darlow and Federico Fernandez look set to miss out.
KEY FACT: Chelsea have only lost one of their 23 PL home matches against Newcastle
MATCH ODDS: Chelsea 1/4 Draw 11/2 Newcastle 14/1
bet365 Pick: Under 2.5 goals @6/5
ANDY SAYS: Chelsea are not going to have too many problems with Newcastle…3-0
GRAEME SAYS: Newcastle are not in great form and it won’t get any better here…4-1
Football Index – One to follow: Callum Hudson-Odoi – a player with a huge future