Tottenham will climb into second with victory over Manchester United on Sunday.
The game of the weekend sees in-form United – who are undefeated under interim boss Ole Gunnar Solskjaer – continue their quest for a top-four spot.
Spurs, knowing Manchester City play on Monday, know victory would very much keep them in the title hunt.
The day’s other game sees a mid-table clash as 11th plays 12th as Everton host Bournemouth at Goodison Park.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Everton 14:15 AFC Bournemouth
TEAM NEWS: New Bournemouth signing Dominic Solanke would be fit to make his debut until next month whilst Simon Francis, Lewis Cook and Adam Smith remain sidelined. The Cherries have question marks over Callum Wilson, Josh King, Ryan Fraser and Dan Gosling – but they hope all four will be fit.
Everton should have a fully fit squad available to boss Marco Silva.
KEY FACT: Everton have won all three of their PL home matches against Bournemouth
MATCH ODDS: Everton 4/5 Draw 29/10 Bournemouth 15/4
bet365 Pick: Both Teams To Score & Over 2.5 goals @Evens
ANDY SAYS: Everton should have enough to win this, Bournemouth are not playing too well…2-0
GRAEME SAYS: Tough call this one, but I think that Everton just about edge it…2-1
Football Index – One to follow: Richarlison – has looked great at Everton, well worth investing in
Tottenham Hotspur 16:30 Manchester United
TEAM NEWS: Victor Wanyama is out, whilst the likes of Jan Vertonghen, Eric Dier and Lucas Moura are major doubts. Erik Lamela, Davinson Sanchez and Harry Winks are suspended.
Paul Pogba is ready to return for United, but Marcos Rojo and Chris Smalling are sidelined. Alexis Sanchez is a major doubt. Eric Bailly is banned.
KEY FACT: Spurs are aiming to be the first team since Everton in 1987 to win four consecutive top-flight home matches against Man Utd
MATCH ODDS: Spurs 21/20 Draw 27/10 Man Utd 11/4
bet365 Pick: Spurs to win @21/20
ANDY SAYS: Really good game here, and I think they will just about cancel each other out…1-1
GRAEME SAYS: I think United could cause a bit of an upset in this one, but will be close either way…1-2
Football Index – One to follow: Anthony Martial – still has everything to make it to the very top