Tottenham Hotspur will come close to guaranteeing a top-four spot with victory on Saturday.
Spurs are yet to taste defeat at their new White Hart Lane home and they will look to continue that against capital rivals West Ham – who season is stuttering to an end having gone five matches without a win.
The battle for seventh will be in the spotlight with Wolves – currently occupying seventh spot – travelling to Watford in eighth, who are one point worse off.
And should Wolves and Watford cancel each other out – Everton, who are ninth and one point further back, could take advantage if they can win at Crystal Palace.
At the bottom and the battle to avoid the final relegation spot is well and truly on with Brighton just three points ahead of Cardiff. A win for Brighton over Newcastle and defeat for Cardiff would all but seal the Bluebirds relegation – but if the opposite happened, then the two sides will go into the final two games of the season level on points.
The final game on Saturday is a South Coast derby as Southampton host rivals Bournemouth.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Tottenham Hotspur 12:30 West Ham United
Tottenham Hotspur Stadium
TEAM NEWS: Dele Alli, Danny Rose, Harry Winks and Erik Lamela are all doubts for Spurs, who are without Moussa Sissoko, Serge Aurier and Harry Kane.
Javier Hernandez, Manuel Lanzini and Aaron Cresswell are in contention but Samir Nasri is set to miss out joining Winston Reid, Andriy Yarmolenko and Andy Carroll on the sidelines.
KEY FACT: Spurs could complete a first league double over West Ham since 2013
MATCH ODDS: Spurs 2/5 Draw 9/2 West Ham 13/2
bet365 Pick: Both Teams To Score @7/10
ANDY SAYS: My old club Spurs have been in great form and they will see off West Ham here…3-1
GRAEME SAYS: Tottenham will continue their good run here, no doubt…2-0
Football Index – One to follow: Christian Eriksen – Could be on the move this summer, if he is then his value is going up
Crystal Palace 15:00 Everton
TEAM NEWS: Palace are without Jeff Schlupp and central defenders James Tomkins and Mamadou Sakho.
Everton are without Yerry Mina, but they hope Theo Walcott, Lucas Digne and Richarlison will be available.
KEY FACT: Palace are looking for their first win in nine Premier League matches against Everton
MATCH ODDS: Palace 13/8 Draw 5/2 Everton 9/5
bet365 Pick: Draw @5/2
ANDY SAYS: I am backing my former club, they will get the better of Everton…2-0
GRAEME SAYS: I am not impressed by Palace, and I can see Everton winning this…1-3
Football Index – One to follow: Wilfried Zaha – Plenty of value in the Palace star
Fulham 15:00 Cardiff City
TEAM NEWS: Cardiff hope to have Harry Arter available, but Joe Ralls has joined Sol Bamba, Callum Paterson and Matthew Connolly on the sidelines.
Fulham could have Alfie Mawson available, but Lazar Markovic, Tim Fosu-Mensah and Marcus Bettinelli are ruled out.
KEY FACT: Cardiff have won all three of their Premier League meetings with Fulham
MATCH ODDS: Fulham 7/5 Draw 13/5 Cardiff 2/1
bet365 Pick: Under 2.5 goals @11/10
ANDY SAYS: I think Fulham will come out on top here, and edge Cardiff towards relegation with them…2-1
GRAEME SAYS: Cardiff are in desperate need of the win and I think they could win this…1-2
Football Index – One to follow: Ryan Sessegnon – This could be one of his final games for Fulham…he has real value on the Index
Southampton 15:00 AFC Bournemouth
TEAM NEWS: Bournemouth are really stretching their squad with eight players likely to be out for The Cherries – including Adam Smith, Junior Stanislas, Nathaniel Clyne, Diego Rico, Charlie Daniels, Andrew Surman, Simon Francis and Lewis Cook.
Southampton hope that Shane Long, Ryan Bertrand and Stuart Armstrong will be available, but Alex McCarthy, Michael Obafemi and Jannik Vestergaard are ruled out.
KEY FACT: Bournemouth are looking for their first away win against Southampton
MATCH ODDS: Southampton 10/11 Draw 29/10 Bournemouth 31/10
bet365 Pick: Draw 29/10
ANDY SAYS: This will be a close game, and I think it ends all square…1-1
GRAEME SAYS: Southampton will get the better of Bournemouth here, whose injuries are mounting…2-0
Football Index – One to follow: Callum Wilson – A top player, who should be looked at
Watford 15:00 Wolverhampton Wanderers
TEAM NEWS: Wolves again have the luxury of a fully-fit squad to choose from.
Watford are without Jose Holebas, Tom Cleverley,
Domingos Quina and Sebastian Prodl.
KEY FACT: Wolves are looking for a first away win in six PL matches
MATCH ODDS: Watford 13/8 Draw 23/10 Wolves 19/10
bet365 Pick: Draw @23/10
ANDY SAYS: This should be one of the games of the weekend, both good teams but I can’t split them…2-2
GRAEME SAYS: I like Wolves a lot, but I think that Watford might edge this being at home…2-1
Football Index – One to follow: Ruben Neves – The Wolves midfielder is an outstanding talent
Brighton & Hove Albion 17:30 Newcastle United
TEAM NEWS: Brighton are set to be without Dutch midfielder Davy Propper once again.
Newcastle hope to have Isaac Hayden and Fabian Schar available, but Miguel Almiron has joined Sean Longstaff and Florian Lejuene in missing the rest of the season.
KEY FACT: Newcastle have never beaten Brighton in the Premier League
MATCH ODDS: Brighton 13/10 Draw 11/5 Newcastle 13/5
bet365 Pick: Brighton to win @13/10
ANDY SAYS: I can see Brighton getting the three points with Newcastle already safe…1-0
GRAEME SAYS: Close game to call and I don’t see many goals indeed this could very well be goalless…0-0
Football Index – One to follow: Miguel Almiron – One to watch for next season, full of value