Champions Manchester City begin the defence of their Premier League title on Saturday.
City face a tricky looking opening game as they travel to West Ham United in the early kick-off on the day.
Newly promoted Aston Villa finish the day with a trip to Tottenham, whilst Sheffield United – back in the top-flight for the first time in a decade – travel to the South Coast to face Bournemouth.
Elsewhere on the opening day, Everton travel to Crystal Palace, Watford host Brighton and Burnley welcome Southampton to Turf Moor.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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West Ham United 12:30 Manchester City
TEAM NEWS: The Hammers are without captain Mark Noble – but they should hand full debuts to record signing Sebastian Haller and Spanish international Pablo Fornals.
City are without Leroy Sane, who they confirmed has damaged knee ligaments. Benjamin Mendy also misses out, but Fernandinho and Aymeric Laporte should be fit to feature.
KEY FACT: The reigning Premier League champions have only lost the first match of their title defence on two occasions
bet365 MATCH ODDS: West Ham 11/1 Draw 11/2 Man City 2/9
bet365 Pick: Both Teams To Score & over 2.5 goals @6/5
ANDY SAYS: No issues for City here, I see them brushing West Ham aside without too many difficulties…1-4
GRAEME SAYS: This is going to be a tough game for City, no doubt but I think they will hit the ground running with a hugely important win…0-2
Football Index – One to follow: Kevin De Bruyne – Has the ability to become the Premier League’s top dog this season
AFC Bournemouth 15:00 Sheffield United
TEAM NEWS: Bournemouth will include new signings Philip Billing, Arnaut Danjuma and Harry Wilson in their squad but they are missing a number through injury including David Brooks, Dan Gosling, Simon Francis, Lewis Cook, Lloyd Kelly and Junior Stanislas.
Sheffield United don’t have any injury issue and they have a host of new names who could make their debuts, such as Luke Freeman, Phil Jagielka, Callum Robinson, Ravel Morrison, Lys Mousset, Ben Osborn and Oli McBurnie.
KEY FACT: Bournemouth have never won a home match against Sheffield United
bet365 MATCH ODDS: Bournemouth 19/20 Draw 13/5 Sheff Utd 13/5
bet365 Pick: Sheff Utd double chance @4/5
ANDY SAYS: Bournemouth will be too good for Sheff United, I like what they did in the window and they will take the opening win…2-0
GRAEME SAYS: You always get a bit of a shock on the opening weekend, and I wonder if Sheff United can get something here…2-2
Football Index – One to follow: Callum Wilson – Needs to have a big season to press his England claims
Burnley 15:00 Southampton
TEAM NEWS: England internationals Jay Rodriguez and Danny Drinkwater could make their debuts for Burnley, but they will be without Steven Defour and Robbie Brady. They hope to have Jack Cork, James Tarkowski and Kevin Long available.
The Saints could give bows to summer arrivals Che Adams and Moussa Djenepo but they do have the luxury of a fully fit squad.
KEY FACT: Burnley are unbeaten in their last five Premier League meetings with Southampton
bet365 MATCH ODDS: Burnley 13/8 Draw 11/5 Southampton 7/4
bet365 Pick: Che Adams to score anytime @11/10
ANDY SAYS: Not an easy game to call, Burnley started slowly last year but I think they get something although I am backing Southampton to claim a point…1-1
GRAEME SAYS: I worry about Southampton this year, and I think Burnley are stronger so I will give them the edge…2-1
Football Index – One to follow: Che Adams – He could be a huge success for Southampton this season
Crystal Palace 15:00 Everton
TEAM NEWS: Palace have midfield recruits Victor Camarasa and James McCarthy available, but the player they are delighted to have in the squad is Wilfried Zaha – but it remains to be seen if he will be involved. James Tomkins is sidelined.
Everton have doubts over new signings Fabian Delph and Jean-Philippe Gbamin, but summer signings Andre Gomes, Alex Iwobi, Djibril Sidibe and Moise Kean should feature. Leighton Baines is not available.
KEY FACT: Everton are unbeaten in their last nine Premier League meetings with Crystal Palace
bet365 MATCH ODDS: Palace 2/1 Draw 9/4 Everton 11/8
bet365 Pick: Everton to win @11/8
ANDY SAYS: I am backing my former club to get off to a good start, Wilf will show his worth and guide them to an opening three points…1-0
GRAEME SAYS: Everton have had a great summer window, and if they want to push for a top-six finish then they will need to win games like this…0-2
Football Index – One to follow: Moise Keane – Could be a genuine star for The Toffees
Watford 15:00 Brighton & Hove Albion
TEAM NEWS: Watford could hand a debut to their new club record signing Ismaila Sarr – but another new boy Danny Welbeck won’t be available along with Adalberto Penaranda, Nathaniel Chalobah, Dimitri Foulquier and Tom Dele-Bashiru – but Gerard Deulofeu and Roberto Pereyra should be available despite recent issues.
Brighton could hand first starts to their own big summer arrivals with Neal Maupay and Adam Webster both in contention, but they will be without Jose Izquierdo, Yves Bissouma and Ezequiel Schelotto.
KEY FACT: Watford have not lost their opening league game since 2006
bet365 MATCH ODDS: Watford 10/11 Draw 12/5 Brighton 3/1
bet365 Pick: Watford to win & Both Teams To Score @19/20
ANDY SAYS: Watford are a good team, they will begin with three points here…2-0
GRAEME SAYS: I can see Brighton struggling big time, and it will start with a Watford win…3-1
Football Index – One to follow: Ismaila Sarr – Could become a huge Premier League star
Tottenham Hotspur 17:30 Aston Villa
Tottenham Hotspur Stadium
TEAM NEWS: Tottenham should field big name summer arrivals Tanguy Ndombele and Giovani Lo Celso, but their other signing Ryan Sessegnon misses out with a thigh problem along with Dele Alli, Eric Dier, Serge Aurier, Ben Davies, Victor Wanyama and Juan Foyth whilst Heung-Min Son is suspended.
James Chester and Anwar El Ghazi both miss out for Villa – who will be handing out a host of debuts having brought in a dozen players over the summer.
KEY FACT: This is the sixth time Spurs are playing their opening match of a Premier League season against a promoted side, losing just once.
bet365 MATCH ODDS: Spurs 3/10 Draw 17/4 Villa 9/1
bet365 Pick: Both Teams To Score @Evens
ANDY SAYS: Tottenham are far too good for Villa, my former team are going to win here…3-1
GRAEME SAYS: I believe Spurs will show up to be far too strong for Villa, they are a bit of an unknown quantity…3-0
Football Index – One to follow: Giovani Lo Celso – A fascinating new signing from Spurs