Premier League leaders Liverpool look to maintain their perfect start to the season on Sunday.
The Reds have a perfect record after five wins and a sixth would equal their best ever start to a Premier League campaign.
But to continue their run Jurgen Klopp’s men have a tough looking challenge in what is the game of the weekend as they visit Stamford Bridge to face Chelsea.
And it is going to be a busy day in the capital as all four games are in London.
Manchester United travel West Ham, Wolves will face Crystal Palace and Arsenal host Aston Villa.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Crystal Palace 14:00 Wolverhampton Wanderers
TEAM NEWS: Palace are hoping to have a fully fit squad with Scott Dann, Martin Kelly, Connor Wickham, James McArthur and James Tomkins all hoping to be back.
Wolves have a fully fit squad to choose from going into the game.
KEY FACT: Crystal Palace are unbeaten in their last four Premier League matches at Selhurst Park
MATCH ODDS: Palace 13/8 Draw 21/10 Wolves 15/8
bet365 Pick: Wolves to score over 1.5 goals @2/1
ANDY SAYS: Close game here, obviously I would like Palace to win but I think Wolves might get a point…1-1
GRAEME SAYS: Wolves really need a win here and I think they get their season going here with a win…0-2
Football Index – One to follow: Ruben Neves – A wonderful player, and only a matter of time before a big move again for him
West Ham United 14:00 Manchester United
TEAM NEWS: Arthur Masuaku is suspended for West Ham, who are also without Michail Antonio, but Winston Reid is closing in on a return whilst Manuel Lanzini should be available.
United are without Eric Bailly and Timothy Fosu-Mensah, whilst Luke Shaw, Anthony Martial and Paul Pogba are likely to miss out, but they hope Daniel James will pass a late fitness test.
KEY FACT: Manuel Pellegrini could become the first boss to beat four different Red Devils managers in the Premier League having beaten David Moyes, Louis van Gaal and Jose Mourinho
MATCH ODDS: West Ham 21/10 Draw 13/5 Man Utd 6/5
bet365 Pick: Penalty in the match @7/4
ANDY SAYS: This should be a good game but I think that Man Utd might just edge it…1-2
GRAEME SAYS: I am not sure I see Man Utd having enough here, I think West Ham could shock them…2-1
Football Index – One to follow: Mason Greenwood – United’s young striking starlet has to be followed
Arsenal 16:30 Aston Villa
TEAM NEWS: Full-backs Hector Bellerin and Kieran Tierney could be available for Arsenal, whilst Konstantinos Mavropanos and Sead Kolasinac could also feature but Alexandre Lacazette is sidelined.
Matt Targett could return for Villa, but Jonathan Kodija and James Chester miss out
KEY FACT: Arsenal have won their last six meetings with Aston Villa
MATCH ODDS: Arsenal 2/5 Draw 15/4 Villa 7/1
bet365 Pick: Under 3.5 goals @8/11
ANDY SAYS: Arsenal will have too much for Villa in this one, home win on its way…2-0
GRAEME SAYS: I can’t see Villa living with Arsenal in this one, comfortable win…3-0
Football Index – One to follow: Kieran Tierney – Ready for his Premier League debut and could emerge as a huge talent
Chelsea 16:30 Liverpool
TEAM NEWS: Ruben Loftus-Cheek, Emerson, Marco van Ginkel and Antonio Rudiger all miss out for Chelsea, but Frank Lampard could be boosted by having Reece James and Callum Hudson-Odoi for the first time this season whilst NGolo Kante and Mason Mount will undergo late fitness tests.
Alisson and Nathaniel Clyne remain sidelined for Liverpool, but Naby Keita and Divock Origi could be available.
KEY FACT: Liverpool have lost only once in their last 44 Premier League matches
MATCH ODDS: Chelsea 5/2 Draw 11/4 Liverpool Evens
bet365 Pick: Liverpool to win & Both Teams To Score @3/1
ANDY SAYS: Liverpool are in wonderful form and Chelsea will not be able to stand in their way…1-3
GRAEME SAYS: Chelsea are playing well, but not sure they have enough to stop Liverpool…0-2
Football Index – One to follow: Tammy Abraham – Looks to be turning into a top-class striker