Leaders Liverpool open up the Premier League weekend with a trip to Sheffield United, looking to maintain their perfect start to the new season.
A win would see Liverpool make it seven wins from seven to start the new season, which would be a record for them – but they do face a tricky looking trip to Bramall Lane.
Champions Manchester City are also in action as they travel to Goodison Park to face an out-of-sorts Everton.
West Ham have the chance to move into the top-four, and to do so they will need to get something from their trip to Bournemouth.
Tottenham look to get back into some sort of form as they host Southampton, also in London Chelsea look to climb into the top-half of the table as they welcome Brighton to Stamford Bridge.
Burnley are looking for back-to-back wins as they travel to Birmingham to take on Aston Villa – who have not won a game since August.
The bottom two, both winless, clash at Molineux as Wolves take on Watford.
Finally Crystal Palace entertain Norwich at Selhurst Park.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Sheffield United 12:30 Liverpool
TEAM NEWS: Xherdan Shaqiri, Nathaniel Clyne and Alisson are all sidelined for Liverpool, who hope that Sadio Mane and Divock Origi will be fir for the trip to Yorkshire.
The Blades are without the suspended Billy Sharp, but may be without any injuries worries with David McGoldrick the only worry.
KEY FACT: Bramall Lane is one of only three grounds Liverpool have played at without winning in the Premier League
MATCH ODDS: Sheff Utd 8/1 Draw 17/4 Liverpool 1/3
bet365 Pick: Under 2.5 goals @11/8
ANDY SAYS: Don’t see an issue here for Liverpool, they are going to win…1-3
GRAEME SAYS: Might be a tougher trip than some think but it is an away win…1-2
Football Index – One to follow: Trent Alexander-Arnold – One of the best full-backs in the world at the moment
AFC Bournemouth 15:00 West Ham United
TEAM NEWS: Dan Gosling, David Brooks, Charlie Daniels, Adam Smith and Junior Stanislas are all sidelined for Bournemouth.
Ryan Fredericks, Winston Reid and Manuel Lanzini are all in contention to feature for The Hammers, but Michail Antonio misses out.
KEY FACT: Callum Wilson has scored six goals in six league appearances against West Ham
MATCH ODDS: Bournemouth 29/20 Draw 13/5 West Ham 7/4
bet365 Pick: Over 2.5 goals & Both Teams To Score @4/5
ANDY SAYS: Should be a good game and I can see West Ham getting something…1-1
GRAEME SAYS: Could go either way this one but I think Bournemouth edge it…2-1
Football Index – One to follow: Callum Wilson – Still on the rise, emerging as a top Premier League striker
Aston Villa 15:00 Burnley
TEAM NEWS: Jonathan Kodija and James Chester miss out for Aston Villa.
Burnley are to welcome Johann Berg Gudmundsson and Dwight McNeil back, but Daniel Drinkwater remains sidelined.
KEY FACT: Aston Villa are looking to record a third consecutive PL clean sheet at home for the first time since December 2012
MATCH ODDS: Villa 11/8 Draw 12/5 Burnley 2/1
bet365 Pick: Jack Grealish to score anytime @5/1
ANDY SAYS: My former club should get the win here, it will be close but I see a home win…2-1
GRAEME SAYS: A really tough call but I would go with Villa to claim the point…1-1
Football Index – One to follow: Jack Grealish – A future England star, he has so much talent
Chelsea 15:00 Brighton & Hove Albion
TEAM NEWS: Ruben Loftus-Cheek, Emerson, Antonio Rudiger are all sidelined Marco van Ginkel, whilst there are doubts over Olivier Giroud and Andreas Christensen.
Brighton hope that they will have Bernardo Solly March, Alireza Jahanbakhsh and Neal Maupay available, but they will be without Leandro Trossard, Ezequiel Schelotto, Jose Izquierdo, Leon Balogun and Shane Duffy.
KEY FACT: Chelsea have won all eight of their league meetings with Brighton
MATCH ODDS: Chelsea 2/5 Draw 15/4 Brighton 7/1
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: Chelsea are hitting their stride under Frank Lampard now, home win…3-1
GRAEME SAYS: I don’t see Brighton travelling to well in this one and Chelsea ease to victory…4-1
Football Index – One to follow: Mason Mount – Outstanding young midfielder who everyone needs to follow
Crystal Palace 15:00 Norwich City
TEAM NEWS: Palace could have a fully fit squad to choose from with the only doubt for Roy Hodgson being Connor Wickham.
Norwich have doubts over Mario Vrancic, Ralf Fahrmann, Tim Krul and Alexander Tettey, and are defintely without Timm Klose, Christoph Zimmermann, Onel Hernandez, Tom Trybull and Max Aarons.
KEY FACT: Palace did the double over Norwich when these sides were last in the Premier League together, in 2015/16
MATCH ODDS: Palace 19/20 Draw 13/5 Norwich 14/5
bet365 Pick: Goal Before 27:00 @5/6
ANDY SAYS: I am going for Palace here, I don’t see my former team not winning with Norwich struggling away from home…2-1
GRAEME SAYS: I see a fairly comfortable win coming for Palace…3-0
Football Index – One to follow: Wilfried Zaha – Palace’s star man, should be the stand-out performer here
Tottenham Hotspur 15:00 Southampton
Tottenham Hotspur Stadium
TEAM NEWS: Alex McCarthy could be available for Southampton, but Moussa Djenepo is sidelined.
Spurs are without loanee Giovani Lo Celso, but Ryan Sessegnon could be available.
KEY FACT: Spurs’ last eight Premier League victories have come at home
MATCH ODDS: Spurs 2/5 Draw 15/4 Southampton 7/1
bet365 Pick: Southampton Double Chance @7/4
ANDY SAYS: Another win for one of my former clubs, I see Spurs claiming the win…2-0
GRAEME SAYS: Which Spurs turn up? I will give them the benefit of the doubt, but won’t be a classic…2-1
Football Index – One to follow: Harry Kane – Still nobody better in the world than what he does
Wolverhampton Wanderers 15:00 Watford
TEAM NEWS: Wolves have the bonus of a fully fit squad to choose from.
Watford are missing Troy Deeney, but they hope to have Craig Cathcart available.
KEY FACT: Watford are only the third side to concede 18 goals in their first six Premier League matches of a season
MATCH ODDS: Wolves 17/20 Draw 23/10 Watford 15/4
bet365 Pick: Wolves to win @17/20
ANDY SAYS: I think Wolves will kick-start their season here…2-0
GRAEME SAYS: I am not convinced about Watford at the moment, has to be a Wolves win…3-0
Football Index – One to follow: Ruben Neves – A sublime player who could play at the very top
Everton 17:30 Manchester City
TEAM NEWS: Andre Gomes and Jean-Philippe Gbamin are both sidelined for Everton.
City are without Leroy Sane, John Stones and Aymeric Laporte.
KEY FACT: Everton have won 10 Premier League home matches against reigning champions
MATCH ODDS: Everton 9/1 Draw 9/2 Man City 3/10
bet365 Pick: Under 3.5 goals @8/11
ANDY SAYS: I am not impressed by City and they win at Goodison comfortable…0-3
GRAEME SAYS: Everton are not in good form and I don’t see how they stop City…0-2
Football Index – One to follow: Kevin De Bruyne – Still value until he is number one