Table topping Liverpool, who still possess a 100% record in the Premier League this season, face their toughest task to date as they host third place Leicester City.
Foxes boss and former Reds chief Brendan Rodgers makes his return to Anfield, and will no doubt receive a warm welcome – although he will be hoping to put an end to their run of seven successive wins at the start of this season.
Victory for Rodgers and Leicester would take them into second as Manchester City don’t play until Sunday.
The day begins on the South Coast with Brighton hosting an out-of-sorts Tottenham, who are recovering from their 7-2 hammering at the hands of Bayern Munich in midweek.
West Ham United host London rivals Crystal Palace in the day’s late kick-off. but they could end the day in third place with victory.
Everton are looking to avoid four successive league defeats, but they face a tough looking task as they visit Lancashire rivals Burnley.
Another team in dire need of a win are Watford, who are yet to pick up a victory this term and new boss Quique Sanchez Flores will be hoping the basement club can beat Sheffield United at Vicrage Road.
And whilst too early to be called a six-pointer, it is 17th v 18th at Carrow Road as Norwich take on Aston Villa.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Brighton & Hove Albion 12:30 Tottenham Hotspur
TEAM NEWS: Brighton are hoping Leon Balogun, Solomon March and Davy Propper will be available, but they are set to be without Leonardo Trossard, Jose Izquierdo, Shane Duffy and Bernardo.
Tottenham are without Giovani Lo Celso and Ryan Sessegnon through injury, whilst Serge Aurier is suspended.
KEY FACT: Brighton have never beaten Tottenham in the Premier League
MATCH ODDS: Brighton 14/5 Draw 13/5 Spurs 19/20
bet365 Pick: Brighton Double Chance @4/5
ANDY SAYS: Spurs have had troubles but my old team claim the win here and they need it…1-3
GRAEME SAYS: Might be a tougher trip than some think but it is an away win…1-2
Football Index – One to follow: Christian Eriksen – Set to leave Spurs and is one to follow here
Burnley 15:00 Everton
TEAM NEWS: Burnley come into the game with Danny Drinkwater and Jack Cork missing.
Everton are without Jean-Philippe Gbamin, but he could be the only absentee with Andre Gomes, Bernardo and Theo Walcott all set to be available.
KEY FACT: There have been no draws in the 10 Premier League meetings between these sides
MATCH ODDS: Burnley 15/8 Draw 23/10 Everton 6/4
bet365 Pick: First goal method @4/1
ANDY SAYS: Everton are not playing well, so has to be a home win – although I don’t see many goals…1-0
GRAEME SAYS: Burnley are playing pretty well, and you have to go with them to win again…2-1
Football Index – One to follow: Andre Gomes – Potential to be one of the Premier League’s top performers
Liverpool 15:00 Leicester City
TEAM NEWS: Alisson and Joel Matip have a chance of making the game but Nathaniel Clyne and Xherdan Shaqiri are ruled out.
Leicester are only missing Matty James, with James Maddison set to return for The Foxes.
KEY FACT: Liverpool are aiming for a 17th successive Premier League victory
MATCH ODDS: Liverpool 4/9 Draw 15/4 Leicester 6/1
bet365 Pick: Leicester Double Chance @13/8
ANDY SAYS: I think Liverpool lose their perfect record here in what I can see being a quality game…2-2
GRAEME SAYS: Leicester are playing well but they get a brought back down to earth here by Liverpool’s quality…2-0
Football Index – One to follow: Trent Alexander-Arnold – One of the best full-backs in the world at the moment
Norwich City 15:00 Aston Villa
TEAM NEWS: Nobody has more injuries in the Premier League than Norwich with Timm Klose, Christoph Zimmermann, Onel Hernandez, Tom Trybull, Tim Krul, Mario Vrancic, Alexander Tettey and Ralf Fahrmann all sidelined but Jamal Lewis and Ben Godfrey will return.
Jonathan Kodija is missing for Villa, whilst the game could come too quickly for James Chester, but Henri Lansbury, Matt Targett, Wesley Moraes and Tyrone Mings should all feature.
KEY FACT: Norwich have only lost one of their 13 home league matches in 2019
MATCH ODDS: Norwich 13/10 Draw 11/4 Villa 15/8
bet365 Pick: Under 2.5 goals & Both Teams To Score @8/11
ANDY SAYS: It’s a tough one but I like Norwich at home so I see them getting the three points…2-1
GRAEME SAYS: Not an easy one and I see them cancelling each other out…1-1
Football Index – One to follow: Teemu Pukki – Has made a wonderful start to his Premier League career
Watford 15:00 Sheffield United
TEAM NEWS: The Hornets are without Troy Deeney, Isaac Success and Will Hughes.
United could have a fully fit squad to choose from with the only doubt being David McGoldrick.
KEY FACT: Watford have won four of their last five Premier League matches against promoted clubs
MATCH ODDS: Watford 23/20 Draw 23/10 Sheff Utd 5/2
bet365 Pick: Watford win @23/20
ANDY SAYS: I like the way that Sheff Utd have been going and I think Watford’s poor run continues…1-2
GRAEME SAYS: I think that Watford claim their opening win of the season here…2-0
Football Index – One to follow: Ismaila Sarr – Could be a real star in the making
West Ham United 17:30 Crystal Palace
TEAM NEWS: Lukasz Fabianski has joined Winston Reid and Michail Antonio on the sidelines for West Ham.
Luka Milivojevic is suspended for Palace, who will have a fully fit squad if Mamadou Sakho makes it.
KEY FACT: The Hammers have won their last three PL London derbies at home
MATCH ODDS: West Ham 19/20 Draw 13/5 Palace 14/5
bet365 Pick: Ryan Fredericks to score anytime @20/1
ANDY SAYS: I think my former club get something from this, in what should be a very good derby…1-1
GRAEME SAYS: Not sure Palace have anything to stop West Ham, comfortable home win…3-0
Football Index – One to follow: Manuel Lanzini – A top-class performer for The Hammers