Super Sunday lives up to the billing this weekend as the game of the season so far, anywhere in the world, takes place as top-of-the-table Liverpool host reigning champions Manchester City.
Liverpool come into the game six points ahead of City – so the game could have huge ramifications in the title as they could end the weekend nine ahead or just three.
There is also a big Midlands derby as Wolves host Aston Villa – who are looking to end a run of two successive wins.
The day opens with Manchester United desperate to return to winning ways as they host Brighton at Old Trafford.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Manchester United 14:00 Brighton & Hove Albion
TEAM NEWS: United hope to have Victor Lindelof and Scott McTominay available, but they still have the worse injury list in the Premier League with up to nine players also ruled out including Paul Pogba, Eric Bailly, Nemanja Matic, Luke Shaw and Axel Tuanzebe. Ashley Young is also suspended.
Brighton are without Jose Izquierdo, Bernardo and Adam Webster.
KEY FACT: All four of the Premier League matches between these sides have been won by the home side
MATCH ODDS: Man Utd 3/5 Draw 11/4 Brighton 11/2
bet365 Pick: Anthony Martial to score anytime @13/8
ANDY SAYS: United are not playing great but I don’t see them not being able to get the win here…1-0
GRAEME SAYS: I don’t see anything impressive about United under Ole…1-1
Football Index – One to follow: Marcus Rashford – Turning into United’s leading light
Wolverhampton Wanderers 14:00 Aston Villa
TEAM NEWS: Wolves are without Wily Boly, but he could be the only player that misses out as they hope Morgan Gibbs-White will return.
Villa are without Keinan Davis and Jota is a major doubt, but captain Jack Grealish and Frederic Guilbert should be available.
KEY FACT: Aston Villa are unbeaten in their last nine top-flight away matches at Wolves
MATCH ODDS: Wolves 10/11 Draw 5/2 Villa 16/5
bet365 Pick: Wolves to win @10/11
ANDY SAYS: I can see Villa going to Molineux and getting something…1-1
GRAEME SAYS: I like both these teams but I think Wolves take the win…2-1
Football Index – One to follow: Ruben Neves – A brilliant young midfielder
Liverpool 16:30 Man City
TEAM NEWS: Man City have some huge injuries with Ederson joining Aymeric Laporte, Leroy Sane. Rodri and Oleksandr Zinchenko sidelined, but they hope captain David Silva will be available.
Liverpool believe their skipper Jordan Henderson will feature but they are without Joel Matip, Xherdan Shaqiri and Nathaniel Clyne.
KEY FACT: Liverpool have only lost one of their last 28 top-flight home matches against Man City
MATCH ODDS: Liverpool 6/4 Draw 13/5 Man City 13/8
bet365 Pick: Draw @13/5
ANDY SAYS: I see goals but I can’t split them – has to be a draw for me…2-2
GRAEME SAYS: I think Pep could inspire his troops, this could go either way but City might just clinch a shock win…1-2
Football Index – One to follow: Raheem Sterling – No better in the Premier League this season