Liverpool and Chelsea will both secure their places in the knockout stage of the Champions League with victories on Wednesday.
Defending champions Liverpool will progress from Group E with victory over Napoli and likewise the Italians will be through if they win – but both will progress if Salzburg fail to beat Genk.
In Group H, Chelsea will be through if they win at Valencia, but the Spaniards will progress if they get the three points.
RB Leipzig and Lyon will both progress from Group G if they beat Benfica and Zenit respectively.
In Group F, there is a huge game between Barcelona and Borussia Dortmund – the winner of which will progress, although the lose will still have their future in their own hands.
We run through every game including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, our own Football Insider Graeme Bailey and BoyleSports’ Lawrence Lyons.
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KRC Genk 20:00 FC Red Bull Salzburg
MATCH ODDS: Genk 15/4 Draw 7/2 Salzburg 6/10
BoyleSports pick: Salzburg to win & Both Teams To Score @6/4
ANDY SAYS: Tough one to call and I think they might just cancel each other out…1-1
GRAEME SAYS: Salzburg need the win here and I think they might just get it…1-2
Football Index – One to follow: Sander Berge – Huge potential in the Norwegian midfield ace
Liverpool 20:00 Napoli
MATCH ODDS: Liverpool 2/5 Draw 15/4 Napoli 13/2
BoyleSports pick: Liverpool to win & Both Teams To Score @9/5
ANDY SAYS: Close game for me but I think Liverpool just edge it…2-1
GRAEME SAYS: I don’t think that Liverpool have too many issue here and they go through with something to spare…3-0
Football Index – One to follow: Trent Alexander-Arnold – A supreme talent at right-back
Barcelona 20:00 Borussia Dortmund
MATCH ODDS: Barcelona 11/20 Draw 10/3 Dortmund 9/2
BoyleSports pick: Barcelona Half Time/Full Time @13/10
ANDY SAYS: I don’t think Barcelona have a major issue here and they go through…3-1
GRAEME SAYS: I can see goals here and think Dortmund can claim a point here…2-2
Football Index – One to follow: Jadon Sancho – Such a huge talent, he has a huge future
Slavia Prague 20:00 Inter Milan
MATCH ODDS: Slavia 12/5 Draw 12/5 Inter 23/20
BoyleSports pick: Inter to win 1-0 @7/1
ANDY SAYS: I think Inter will get held in this one and Slavia get the draw…1-1
GRAEME SAYS: Has to be an Inter win for me, they will have too much quality…0-2
Football Index – One to follow: Lautoro Martinez – A brilliant young striker
Zenit St Petersburg 17:55 Lyon
MATCH ODDS: Zenit 13/10 Draw 23/10 Lyon 2/1
BoyleSports pick: Both Teams To Score & Draw @10/3
ANDY SAYS: I like the look of Lyon and I think they will get the three points here…1-2
GRAEME SAYS: Tough call here and a trip to Moscow is not easy and I think it is a draw…1-1
Football Index – One to follow: Memphis Depay – Looking back to his very best
RB Leipzig 20:00 Benfica
MATCH ODDS: Leipzig 1/2 Draw 7/2 Benfica 11/2
BoyleSports pick: Timo Werner to score first @5/2
ANDY SAYS: Benfica have been really poor and nothing will change here with a home win…2-0
GRAEME SAYS: Don’t see a real issue for Leipzig here, big home win coming…3-1
Football Index – One to follow: Timo Werner – Huge talent
Valencia 17:55 Chelsea
MATCH ODDS: Valencia 12/5 Draw 13/5 Chelsea 21/20
BoyleSports pick: Chelsea to win 2-1 @15/2
ANDY SAYS: I see Chelsea getting the big win here, they are playing so well…1-2
GRAEME SAYS: Chelsea get the win here, little doubt for me…0-2
Football Index – One to follow: Tammy Abraham – Making huge strides
Lille 20:00 Ajax
MATCH ODDS: Lille 11/4 Draw 14/5 Ajax 20/23
BoyleSports pick: Ajax to win 2-0 @10/1
ANDY SAYS: I like Ajax, and they are playing well – they win here…1-3
GRAEME SAYS: A close game for sure and think Ajax just edge the win…1-2
Football Index – One to follow: Hakim Ziyech – A brilliant young player