Liverpool could extend their lead at the top of the Premier League to over 10 points on Saturday.
Three of the top-four are in action on Saturday, but with second placed Leicester not in action until Sunday – Liverpool will see their current eight point lead extended if they beat Brighton at Anfield.
Manchester City do have the chance to close the gap and moved into second, at least temporarily as they feature in the opening game of the weekend as they visit the North East to visit Newcastle.
Fourth placed Chelsea will look to return to winning ways as they host West Ham at Stamford Bridge, whose manager Manuel Pellegrini is under huge pressure.
Jose Mourinho is looking for a third successive win since taking charge of Tottenham and somewhat amazingly Spurs could end the day in fifth place if they Bournemouth at home – despite the fact they start the day in tenth.
Burnley in seventh are looking for a third successive win as they host Crystal Palace – who are looking to end an awful run of three losses on the bounce.
Finally, it is a real six-pointer at St Mary’s as the bottom-two clash with basement side Watford travelling to Southampton.
See below for a preview on every game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Football Index is a stockmarket game where players, known as Traders, take a position on the “future success” of footballers with real money – CLICK HERE to play and start winning, and take advantage of your £20 cashback only with TheGamblingTimes.
Newcastle United 12:30 Manchester City
St. James’ Park
TEAM NEWS: Newcastle should welcome back Florian Lejeune but captain Jamaal Lascelles and Matt Ritchie are sidelined. | City have some huge names missing with Sergio Aguero, Leroy Sane, Aymeric Laporte and Oleksandr Zinchenko all injured.
KEY FACT: Newcastle are looking to secure back-to-back Premier League victories over Man City for the first time since November 2003
MATCH ODDS: Newcastle 13/1 Draw 7/1 Man City 1/6
bet365 Pick: Under 2.5 goals @7/4
ANDY SAYS: Big win coming for Man City, I have little doubt – have not been overly impressed with Newcastle…0-4
GRAEME SAYS: I do wonder if we see the title handed to Liverpool here with Newcastle grabbing a sneaky win…2-1
Football Index – One to follow: Phil Foden – One of the best young talents in world football
Burnley 15:00 Crystal Palace
TEAM NEWS: Ashley Westwood is suspended for Burnley, but he could be the only player missing with Johann Berg Gudmundsson, Daniel Drinkwater and Matej Vydra all in contention to return. | The only player missing out for Palace is full-back Joel Ward.
KEY FACT: Only Leicester have kept more Premier League clean sheets than Burnley this season
MATCH ODDS: Burnley 5/4 Ddraw 9/4 Palace 23/10
bet365 Pick: Both Teams Not To Score @4/5
ANDY SAYS: My former club are better than their record and I think they have enough to get a point here…1-1
GRAEME SAYS: Burnley are flying and don’t see Palace being able to stop them here …2-0
Football Index – One to follow: Nick Pope – The Burnley goalkeeper is quite possibly England’s number one
Chelsea 15:00 West Ham United
TEAM NEWS: Jack Wilshere and Winston Reid are rated doubtful for West Ham, who are already without Lukasz Fabianski, Manuel Lanzini and the suspended Issa Diop. | Chelsea are without Ruben Loftus-Cheek, but Marco van Ginkel and Antonio Rudiger are back in training. They hope Ross Barkley, Tammy Abraham and Callum Hudson-Odoi will be fit enough to feature.
KEY FACT: Chelsea are unbeaten in their last 13 home Premier League meetings with West Ham
MATCH ODDS: West Ham 31/10 Draw 16/5 Spurs 3/4
bet365 Pick: Chelsea to win & Both Teams To Score @7/5
ANDY SAYS: Chelsea are playing well and they will win here for me, West Ham are just not good enough…2-0
GRAEME SAYS: Chelsea are just too good for West Ham, simple as that …4-0
Football Index – One to follow: Christian Pulisic – Really is on form at the moment, a huge talent
Liverpool 15:00 Brighton & Hove Albion
TEAM NEWS: Fabinho, Joel Matip and Nathaniel Clyne miss out for Liverpool, but Naby Keita should return. | Brighton are still without Jose Izquierdo, but Aaron Connolly, Bernardo and Solly March could feature.
KEY FACT: Brighton have lost their last seven games against Liverpool
MATCH ODDS: Liverpool 2/11 Draw 6/1 Brighton 14/1
bet365 Pick: Liverpool to win & Under 3.5 goals @21/20
ANDY SAYS: I don’t see Brighton troubling Liverpool here, big home win…3-0
GRAEME SAYS: Brighton will give a good account of themselves in this one but Liverpool will get the win …2-1
Football Index – One to follow: Alisson – Has proven himself as one of the world’s best goalkeepers this season
Tottenham Hotspur 15:00 AFC Bournemouth
Tottenham Hotspur Stadium
TEAM NEWS: Jack Wilshere and Winston Reid rated doubtful for West Ham, who are already , who will still be without Lukasz Fabianski and Manuel Lanzini | Jose Mourinho is still without Erik Lamela, Ben Davies and goalkeepers Hugo Lloris and Michel Vorm.
KEY FACT: Spurs are looking for back-to-back league wins for the first time since April
MATCH ODDS: Spurs 4/11 Draw 9/2 Bournemouth 13/2
bet365 Pick: Both Teams To Score @7/10
ANDY SAYS: My former club Spurs will have huge impetus coming into this game with Jose winning two games and they will win…2-0
GRAEME SAYS: Tottenham will continue their good run of form and beat Bournemouth here …3-0
Football Index – One to follow: Dele Alli – Really is starting to look like his former self
Southampton 17:30 Watford
St. Mary’s Stadium
TEAM NEWS: Stuart Armstrong is ruled out for Southampton but Sofiane Boufal and Jannik Vestergaard could feature. | Domingos Quina, Daniel Bachmann and Roberto Pereyra could return for Watford, but they are without Tom Cleverley, Craig Dawson, Danny Welbeck, Sebastian Prodl, Daryl Janmaat and Christian Kabasele
KEY FACT: Watford are looking to win consecutive away league matches for the first time since 2017
MATCH ODDS: Southampton 11/10 Draw 12/5 Watford 5/2
bet365 Pick: Southampton to win @11/10
ANDY SAYS: I see Southampton getting the win here, but this should be a cracker…2-1
GRAEME SAYS: This will be a great game and I think it will end all square…1-1
Football Index – One to follow: Ismaila Sarr – Surely won’t be long before he finds his form