League leaders Liverpool face neighbours Everton with the chance to move 11 points clear at the top-of-the-table.
The Reds play host to their Stanley Park rivals in fine form, having only dropped points in one game so far this season – but Everton come into the match sat fourth from bottom and with manager Marco Silva under huge pressure.
Leicester will look to try and keep up some pressure on Liverpool at the top, and they will be hopeful of victory as they host bottom-of-the-table and manager-less Watford.
Fourth placed Chelsea are looking to bounce back to form following successive defeats as they host Aston Villa at Stamford Bridge.
Another huge game on Wednesday sees Jose Mourinho takes his new club Tottenham to face Manchester United, his first time back at Old Trafford since they sacked him last season. And whilst United are struggling for form, Spurs are in red hot form under Mourinho – who has won every game since taking charge.
Elsewhere, Wolves welcome West Ham to Molineux whilst Norwich travel to Southampton in what is a big six-pointer at the wrong end of the table.
See below for a preview on the game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Football Index is a stockmarket game where players, known as Traders, take a position on the “future success” of footballers with real money – CLICK HERE to play and start winning, and take advantage of your £20 cashback only with TheGamblingTimes.
Chelsea 19:30 Aston Villa
TEAM NEWS: Ross Barkley and Tammy Abraham should return for Chelsea, whilst there is still a question mark over Antonio Rudiger but Ruben Loftus-Cheek and Marco van Ginkel remain sidelined. | Anwar El Ghazi and Jota could return for Villa, but they are without the suspended Frederic Guilbert.
KEY FACT: Villa are looking for their first Premier League win in London in nine matches
MATCH ODDS: Chelsea 2/7 Draw 19/4 Villa 9/1
bet365 Pick: Over 3.5 goals @11/10
ANDY SAYS: Chelsea need to get back to winning ways and I think they will…2-0
GRAEME SAYS: Villa are playing well but I have to go with Chelsea to win…2-1
Football Index – One to follow: Mason Mount – Has emerged in superb fashion this season
Leicester City 19:30 Watford
King Power Stadium
TEAM NEWS: Matty James remains sidelined for Leicester who will give a late fitness test to Demarai Gray. | Craig Dawson, Christian Kabasele and Kiko Femenia could all feature for Watford, but
Danny Welbeck, Tom Cleverley, Sebastian Prodl and Daryl Janmaat are out.
KEY FACT: Leicester have won all five of their Premier League home matches against Watford
MATCH ODDS: Leicestere 4/11 Draw 4/1 Watford 15/2
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: Comfortable win here for Leicester, no way Watford get anything in this one…3-0
GRAEME SAYS: Watford are not playing well and there is no way they get a result here…2-0
Football Index – One to follow: Youri Tielemans – Has been brilliant and one of the best midfielders in England
Manchester United 19:30 Tottenham Hotspur
TEAM NEWS: There is a chance that Paul Pogba, Nemanja Matic and Scott McTominay could return but Eric Bailly, Timothy Fosu-Mensah, Diogo Dalot and Marcos Rojo are ruled out. | Spurs are still without Hugo Lloris and Michel Vorm, whilst Erik Lamela and Bem Davies are sidelined.
KEY FACT: Jose Mourinho could become the first ever Spurs boss to win their first three top-flight matches in charge of the club
MATCH ODDS: Man Utd 8/5 Draw 5/2 Spurs 13/8
bet365 Pick: Draw @5/2
ANDY SAYS: This should be a really good game, has some many stories but I think it ends in a draw…1-1
GRAEME SAYS: Spurs are in great form, but a win here is tough and I think United just about get something…2-2
Football Index – One to follow: Dele Alli – Is looking in wonderful form
Southampton 19:30 Norwich City
TEAM NEWS: Sofiane Boufal is a doubt for Southampton, who are already without Stuart Armstrong. | Alex Tettey and Grant Hanley are question marks for Norwich, but Josip Drmic and Timm Klose are sidelined.
KEY FACT: Southampton have won their last three homes games against Norwich
MATCH ODDS: Southampton 3/4 Draw 3/1 Norwich 10/3
bet365 Pick: Danny Ings to score anytime @6/5
ANDY SAYS: I think Southampton get another win here, they are playing quite well…2-1
GRAEME SAYS: Norwich have shown a bit of form in recent weeks but for me Southampton at home will get the win…2-0
Football Index – One to follow: Todd Cantwell – Really starting to show fine form, very much one to keep an eye on
Wolverhampton Wanderers 19:30 West Ham United
TEAM NEWS: Morgan Gibbs-White and Wily Boly miss out for Wolves, who hope to have Ryan Bennett available. | West Ham are without Manuel Lanzini, Winston Reid, Jack Wilshere and Lukasz Fabianski.
KEY FACT: Wolves are looking to claim three consecutive league victories over West Ham for the first time
MATCH ODDS: Wolves 4/5 Draw 11/4 West Ham 10/3
bet365 Pick: Wolves to nil @2/1
ANDY SAYS: This should be a very good game but I think Wolves just come out on top…2-1
GRAEME SAYS: West Ham had a very good win at Chelsea, but it won’t be two in a row – Wolves win…2-0
Football Index – One to follow: Adama Traore – Starting to really show on a regular basis just how good he is
Liverpool 20:15 Everton
TEAM NEWS: Liverpool have number one Alisson suspended, who is ruled out along with Fabinho, Nathaniel Clyne and Joel Matip. | Everton hope to have Fabian Delph, Theo Walcott and Seamus Coleman available, but Jean-Philippe Gbamin, Andre Gomes and Cuco Martina are sidelined.
KEY FACT: Liverpool are unbeaten in their last 17 Premier League matches against Everton
MATCH ODDS: Liverpool 1/3 Draw 17/4 Everton 8/1
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: My old team get the win here, with Bournemouth struggling at the moment…2-1
GRAEME SAYS: Everton have an awful record at Anfield and it won’t be changing here…2-0
Football Index – One to follow: Sadio Mane – Proving himself as one of the world’s best