Saturday sees Premier League leaders Liverpool looking to continue their brilliant form at the top-of-the-table, whilst the game of the day is in Manchester as City host United.
Liverpool will be confident of maintain their unbeaten start to the season as they face out-of-form Bournemouth on the South Coast.
Champions Manchester City know they can’t afford to drop many more points, and they face neighbours Manchester United in what is sure to be a spicy affair at the Etihad in the day’s late kick-off.
The day’s opening game sees fourth placed Chelsea travel to manager-less Everton, who sacked Marco Silva on Thursday evening.
Tottenham are looking to bounce back from their first loss under Jose Mourinho as they play host to Burnley.
Crystal Palace start the weekend in 7th, and they could end it as high as 5th if they win at lowly Watford – who are yet to appoint Quique Sanchez Flores’s successor.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Football Index is a stockmarket game where players, known as Traders, take a position on the “future success” of footballers with real money – CLICK HERE to play and start winning, and take advantage of your £20 cashback only with TheGamblingTimes.
Everton 12:30 Chelsea
TEAM NEWS: Fabian Delph and Seamus Coleman could be available but Jean-Philippe Gbamin, Andre Gomes and Cuco Martina are ruled out. | Ruben Loftus-Cheek and Marco van Ginkel are sidelined, but Antonio Rudiger, Ross Barkley and Tammy Abraham should be available.
KEY FACT: Everton have won six of their last 10 home league matches against Chelsea
MATCH ODDS: Everton 5/2 Draw 11/4 Chelsea Evens
bet365 Pick: Over 2.5 goals & Both Teams To Score @20/21
ANDY SAYS: Chelsea are just such a good team at the moment and I don’t see Everton stopping them…0-2
GRAEME SAYS: I can see Everton having some sort of bounce factor with Marco Silva leaving and getting a point…1-1
Football Index – One to follow: Mason Mount – the Chelsea starlet has been brilliant so far this season
AFC Bournemouth 15:00 Liverpool
TEAM NEWS: Adam Smith, Lloyd Kelly and Andrew Surman remain major doubts for Bournemouth, who are still without Junior Stanislas, Joshua King, Charlie Daniels, David Brooks and Steve Cook | Fabinho, Joel Matip and Nathaniel Clyne are sidelined for Liverpool.
KEY FACT: Liverpool have won their last four Premier League meetings with AFC Bournemouth by at least three goals
MATCH ODDS: Bournemouth 6/1 Draw 17/4 Liverpool 2/5
bet365 Pick: Liverpool & Over 3.5 goals @15/8
ANDY SAYS: Liverpool wins keeps going, Bournemouth are really struggling at the moment…1-3
GRAEME SAYS: Don’t see Liverpool relinquishing their unbeaten record here…0-2
Football Index – One to follow: Sadio Mane – Few better players in world football at the moment
Tottenham Hotspur 15:00 Burnley
Tottenham Hotspur Stadium
TEAM NEWS: Goalkeepers Hugo Lloris and Michel Vorm are sidelined, along with Erik Lamela and Ben Davies are sidelined. | Ashley Barnes, Ashley Westwood and Charlie Taylor should be fit for Burnley, but Johann Berg Gudmundsson, Kevin Long and Phil Bardsley are set to miss out.
KEY FACT: Spurs have won seven of their last eight home meetings with Burnley
MATCH ODDS: Spurs 2/5 Draw 15/4 Burnley 7/1
bet365 Pick: Dele Alli to score first @7/1
ANDY SAYS: Tottenham will bounce back from their midweek loss with victory here…2-0
GRAEME SAYS: Have to go with Jose and Spurs in this one to return to winning ways…2-0
Football Index – One to follow: Dele Alli – Bouncing back to his best form
Watford 15:00 Crystal Palace
TEAM NEWS: Craig Dawson and Christian Kabasele should return for Watford, but they are without Danny Welbeck, Tom Cleverley, Sebastian Prodl, Daryl Janmaat and Jose Holebas. | Mamadou Sakho is suspended for Palace, who are also without Joel Ward and Patrick van Aanholt. Max Meyer, Gary Cahill and Scott Dann could feature.
KEY FACT: Palace have only lost one of their last eight away league encounters with Watford
MATCH ODDS: Watford 11/8 Draw 23/10 Palace 21/10
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: My former team Palace are playing really well and I see them getting the win here, and a good one…1-3
GRAEME SAYS: I think that Watford might just be able to grab a point here…1-1
Football Index – One to follow: Wilfried Zaha – Is really stepping up at the moment, and is one of the form players in the league
Manchester City 17:30 Manchester United
TEAM NEWS: Oleksandr Zinchenko has a chance of returning for Man City, but Aymeric Laporte, Leroy Sane and Sergio Aguero remain sidelined. | Paul Pogba and Nemanja Matic both have an outside chance of making the game, but United are still without a number of players including Eric Bailly, Timothy Fosu-Mensah, Diogo Dalot, Marcos Rojo and Anthony Martial
KEY FACT: Man Utd have only lost one of their last four away league matches against Man City
MATCH ODDS: Man City 3/10 Draw 9/2 Man Utd 9/1
bet365 Pick: Under 2.5 goals @13/8
ANDY SAYS: This will be a good game for sure and a close on but I go with City just to edge it…2-1
GRAEME SAYS: Marcus Rashford aside, United are just not impressive and City’s quality wins out…2-0
Football Index – One to follow: Kevin De Bruyne – Starting to show form, which makes him one of the best players on the planet