A packed Super Sunday programme is headlined by second placed Leicester looking to carry on their brilliant start to the season.
Leicester face a Midlands derby clash with Aston Villa in what is the stand-out fixture.
Fifth placed Wolves look to keep up their good form as they travel to the South Coast to take on Brighton.
There are a couple of big games at the wrong end of the table with fourth-from-bottom Southampton looking for a fourth successive win at Newcastle United, whilst second-bottom Norwich play host to Sheffield United.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Aston Villa 14:00 Leicester City
TEAM NEWS: Anwar El Ghazi is a doubt for Villa, who are without Keinan Davis and Jed Steer. | Matt James is sidelined for Leicester, who hope to have Ben Chilwell and Demarai Gray fit.
KEY FACT: Brendan Rodgers has won all four of his Premier League matches at Villa Park
MATCH ODDS: Villa 16/5 Draw 29/10 Leicester 4/5
bet365 Pick: Jamie Vardy +2 shots on target @11/8
ANDY SAYS: I don’t like going against my former club, but Leicester are a very good team…1-3
GRAEME SAYS: I can see goals in this one but I also think Villa can hold Leicester to a draw…2-2
Football Index – One to follow: Jamie Vardy – Can his goalscoring form continue?
Newcastle United 14:00 Southampton
St. James’ Park
TEAM NEWS: Southampton have just one player missing, Stuart Armstrong. | Newcastle come into the game with doubts over Florian Lejeune, DeAndre Yedlin, Andy Carroll and Allan Saint-Maximin but Matt Ritchie and Jamaal Lascelles are out.
KEY FACT: Southampton are looking for their first win at St James’ Park since 2015
MATCH ODDS: Newcastle 6/4 Draw 11/5 Southampton 19/10
bet365 Pick: Danny Ings to score anytime @21/10
ANDY SAYS: Newcastle are playing well and I think they can take the win in this one…2-1
GRAEME SAYS: Both teams are playing well, and I think they cancel each other out…1-1
Football Index – One to follow: Danny Ings – Playing some great football at the moment
Norwich City 14:00 Sheffield United
TEAM NEWS: The Blades have the blessing of having a fully fit squad to choose from. | Grant Hanley could be available for Norwich but Josip Drmic and Timm Klose are out,
MATCH ODDS: Norwich 19/10 Draw 5/2 Sheff Utd 11/8
bet365 Pick: Draw @5/2
ANDY SAYS: I think that Sheffield United have enough to go to Norfolk and win…1-2
GRAEME SAYS: If Norwich want to stay up, they need to win this game…2-1
Football Index – One to follow: Max Aarons – One of the best young full-backs in the Premier League
Brighton & Hove Albion 16:30 Wolverhampton Wanderers
TEAM NEWS: Jose Izquierdo is ruled out for Brighton but Solly March and Bernardo could be back. | Wolves are without Wily Boly and Morgan Gibbs-White.
MATCH ODDS: Brighton 13/8 Draw 21/10 Wolves 15/8
bet365 Pick: Under 2.5 goals @8/13
ANDY SAYS: Wolves are playing well and I think they will grab a win here…1-2
GRAEME SAYS: Tough game to call this one, I think Brighton being at home means they take a point…1-1
Football Index – One to follow: Adam Traore – Starting to look like the player we know he is