Sunday sees England’s biggest rivalry play out once again as runaway leaders Liverpool host Manchester United at Anfield.
The day’s other game sees third-placed Leicester looking to bounce back to form at Burnley.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
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Burnley 14:00 Leicester City
TEAM NEWS: Burnley hope to have Jay Rodriguez, Chris Wood and Robbie Brady, but Johann Berg Gudmundsson and Ashley Barnes are sidelined. | Daniel Amartey and Wilfred Ndidi are ruled out, but Matty James and Wes Morgan are back in training.
KEY FACT: Leicester are looking to record a league double over Burnley for the first time since the 2013
MATCH ODDS: Burnley 16/5 Draw 5/2 Leicester 20/23
bet365 Pick: Leicester to win @20/23
ANDY SAYS: Leicester will just be too strong in this one for Burnley and take the win…1-3
GRAEME SAYS: Burnley need a result but this is a tough one for them, but I can see a point for them …1-1
Football Index – One to follow: James Maddison – Continuing to show what a wonderful player he is
Liverpool 16:30 Manchester United
TEAM NEWS: Dejan Lovren, Joel Matip and Fabio Tavares could be involved for Liverpool. but Naby Keita, Nathaniel Clyne and James Milner are ruled out. | Marcus Rashford and Eric Bailly are hoping to be involved for United, but Scott McTominay, Paul Pogba, Axel Tuanzebe, Marcos Rojo and Luke Shaw are sidelined.
KEY FACT: The Reds are unbeaten in 38 Premier League matches, the third-longest such run in the competition’s history. The two longer streaks, Arsenal’s 49-match record and Chelsea’s 40-match sequence, were both ended by Man Utd
MATCH ODDS: Liverpool 4/11 Draw 15/4 Man Utd 7/1
bet365 Pick: Under 2.5 goals @6/5
ANDY SAYS: The champions-elect are going to win this, little doubt about it…2-0
GRAEME SAYS: A big win is coming for Liverpool, this is not a good United side…3-0
Football Index – One to follow: Sadio Mane – Could be on his way to Football of the Year honours