Premier League leaders Manchester City face their opening game of 2018 on Tuesday as play host to Watford.
City’s record breaking winning streak of 18 games came to an end in a draw at Crystal Palace but they will be hoping to return to winning ways.
There is a huge relegation battle at the London Stadium as third from bottom West Ham host second from bottom West Brom.
Indeed all three teams in the drop-zone are in action as bottom of the table Swansea host Tottenham – who will move into fifth with victory.
The final game is another that can be described as a six-pointer – with Southampton in 15th just two points above the drop zone and one point better off than 17th placed Crystal Palace, who they will face St Mary’s.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Southampton 19:45 Crystal Palace
St. Mary’s Stadium
TEAM NEWS: Alex McCarthy looks set to keep his place in goal for Southampton, whilst left-back Ryan Bertrand could return. Charlie Austin remains injured and suspended. Ruben Loftus-Cheek, James McArthur and Jeffrey Schlupp could all return but Jason Puncheon and Scott Dann are ruled out.
KEY FACT: Southampton have won seven and drawn the other of their eight Premier League home matches against Crystal Palace
MATCH ODDS: Southampton Evs Draw 5/2 Palace 16/5
bet365 Pick: Draw @5/2
ANDY SAYS: A tough game to call, but I think Palace will get something…1-1
GRAEME SAYS: I firmly believe Palace will be getting the three points here…0-2
SILKY SAYS: I can see this playing out as a draw…1-1
FOOTBALLIndex – One to follow: Christian Benteke at 88p, has dropped outside the top-200
Swansea City 19:45 Tottenham Hotspur
Liberty Stadium
Live On Sky Sports
TEAM NEWS: Tammy Abraham and Wilfried Bony are doubts for Swansea, whilst Kyle Naughton is banned and Ki Sung-yueng and Kyle Bartley are injured. Harry Kane is a doubt due to a heavy cold, whilst Victor Wanyama could be his long-awaited return from injury.
KEY FACT: Tottenham are on a 14-match unbeaten run against Swansea
MATCH ODDS: Swansea 11/1 Draw 17/4 Spurs 1/3
bet365 Pick: Spurs win & Over 2.5 goals @10/11
ANDY SAYS: Have to go with my former club here, they will have too much…0-2
GRAEME SAYS: Don’t see this being easy but Tottenham should win…1-2
SILKY SAYS: Comfortable win for Spurs – easy three points…0-3
FOOTBALLIndex – One to follow: Just over £2 and Christian Eriksen’s looks very good value
West Ham United 19:45 West Bromwich Albion
London Stadium
TEAM NEWS: Captain Mark Noble remains a doubt for West Ham but Reece Oxfored could be involved after returning from his loan spell in Germany. But Michail Antonio, Sam Byram, Jose Fonte and Edimilson Fernandes are out. Salomon Rondon is struggling with a hamstring injury whilst Nacer Chadli and James Morrison are sidelined.
KEY FACT: The Baggies are winless in 19 top-flight games
MATCH ODDS: West Ham 19/20 Draw 12/5 West Brom 7/2
bet365 Pick: Both Teams to Score @11/10
ANDY SAYS: I think West Ham should be winning this, but it won’t be easy…1-0
GRAEME SAYS: Could be a better game than some think, I think a big score draw…2-2
SILKY SAYS: Have to go with a home win, don’t think West Brom are going to get anything…2-0
FOOTBALLIndex – One to follow: Manuel Lanzini is a great prospect in the Index at £1.21
Manchester City 20:00 Watford
Etihad Stadium
TEAM NEWS: John Stones and Sergio Aguero could be sidelined – Gabriel Jesus, Kevin De Bruyne and David Silva are all sidelined. Troy Deeney continues his suspension, whilst Watford are waiting on the fitness of over six players.
KEY FACT: Manchester City have won their last seven meetings with Watford
MATCH ODDS: Man City 1/6 Draw 15/2 Watford 18/1
bet365 Pick: Man City win & Over 3.5 goals @10/11
ANDY SAYS: Easy home win, I don’t see it any other way…4-1
GRAEME SAYS: City have some big names out but they will win…0-3
SILKY SAYS: City three points all the way, no doubt about it…0-4
FOOTBALLIndex – One to follow: Raheem Sterling at £3.52 is just inside the top-20