It’s top against bottom in the opener and although the Giants got their first win at Wigan last weekend, the Betfred Super League leaders Saints should win at Huddersfield by at least 20.
Hull FC and Trinity have had mixed starts to the season but the Black and Whites are likely to make home advantage tell and win by 4.
Leeds Rhinos have struggled to make an impact so far, but will be too strong and should beat league new-boys London by 10.
What a classic in store for Warrington who play great rivals Wigan in the game of the round. Wolves will relish taking revenge on the Warriors who have been woeful this season, and will win by at least 10.
Hull KR will surely put Catalans to the sword, especially as the Dragons will still be shell shocked after being humiliated at home by Salford.
Finally, second place Castleford will be looking to put the league’s surprise team Salford in their place and may well triumph by 8.
Huddersfield 9/4, Saints 4/11, Tie 22/1
Saints to win by 13+ points – 6/5 with Betfred
Hull FC 2/5, Wakefield 9/4, Tie 20/1
Hull FC to win by 1-10 points – 5/2 with Betfred
Leeds 1/7, London 5/1, Tie 33/1
Leeds to win by 1-12 points – 5/2 with Betfred
Warrington 1/3, Wigan 5/2, Tie 22/1
Warrington to win by 11-20 points – 11/4 with Betfred