Manchester United travel to Spain on Wednesday for the first-leg of their Champions League last 16 clash with Sevilla.

United go to the Sanchez Pizjuan as firm favourites but boss Jose Mourinho is taking the threat of the Spanish side serious.

 “Sevilla have a good knockout mentality. They’re a club of cups, a team that enjoys the Copa del Rey and the Europa League. Now they have the chance to compete in the biggest competition of all,” he said.

Mourinho insists that nobody will be looking towards a final place until after this stage.

“I normally say that Champions League dreams start around the quarter finals. Not here, not the last 16. Now it still looks a long way to go. When the team reaches the last eight then even those who are not favourites realising that anything is possible,” he said.

“But for the moment our job is just to focus on a team who will provide very difficult opponents. This match, alone, doesn’t decide anything, but it is very important.”

The other game on Wednesday sees Ukrainian giants Shakhtar Donetsk host Roma, although the game is still not being played in their home city but in Metalist.

See below for a run-down on the games, including predictions from our own Football Insider Graeme Bailey together with everything you need to know from the bookies – with BoyleSports’s Leon Blanche.

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TEAM NEWS: Paul Pogba is in line to return to United’s starting line-up after illness, whilst Ander Herrera and Marcus Rashford are expected to feature. Zlatan Ibrahimovic could also make the bench but Marcos Rojo, Phil Jones, Daley Blind and Marouane Fellaini are likely to miss out. For Sevilla they are waiting on the fitness of Sebastien Corchia, Ever Banega and Joaquin Correa.
KEY FACT: This will be the first competitive meeting between Sevilla and Manchester United
MATCH ODDS: Sevilla 9/5 Draw 9/4 Man Utd 13/8
GRAEME SAYS: I don’t think United will lose this game, they should edge a win…1-2
BOYLESPORTS PICK: Draw @9/4
FOOTBALLIndex – One to follow: Paul Pogba is now under £5 – surely one to buy

TEAM NEWS: Shakhtar go into the game without suspended captain Darijo Srna, whilst Maksym Malyshev misses out but they hope Brazilian Bernard will be available. Luca Pellegrini and Rick Karsdorp are sidelined for Roma whilst they are waiting on Maxime Gonalons and Alessandro Florenzi.
KEY FACT: Shakhtar have won all three of their previous CL round of 16 home games 
ODDS: Shakhtar 29/20 Draw 23/10 Roma 2/1
GRAEME SAYS: I can see Roma coming away with the win, but it will be close…0-1
BOYLESPORTS PICK: Both Teams To Score @3/4
FOOTBALLIndex – One to follow: Cengiz Under is a player on fire in the flesh and on the Index