Wednesday sees European champions Liverpool back in action as they travel to Belgium.
Jurgen Klopp takes his side to Genk as they look for a second straight victory in Group E.
Chelsea look to move top of Group H as they take on Ajax in Amsterdam.
The game of the evening takes place in Group F – considered the group of death – Inter Milan host German giants Borussia Dortmund.
We run through every game including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, our own Football Insider Graeme Bailey and BoyleSports’ Lawrence Lyons.
GROUP E
FC Red Bull Salzburg 20:00 Napoli
MATCH ODDS: Salzburg 6/4 Draw 14/5 Napoli 7/5
BoyleSports pick: Both Teams to Score & over 2.5 goals @4/7
ANDY SAYS: Not an easy trip for Napoli and I think they slip up here and draw…1-1
GRAEME SAYS: I think Napoli could slip up here and it is a home win…2-0
Football Index – One to follow: Eling Haaland – A brilliant young talent
KRC Genk 20:00 Liverpool
MATCH ODDS: Genk 8/1 Draw 9/2 Liverpool 2/7
BoyleSports pick: Liverpool Half TIme/Full Time @4/5
ANDY SAYS: Liverpool will get the job done here…1-3
GRAEME SAYS: Liverpool dropped Premier League points at the weekend but they will win here…0-2
Football Index – One to follow: Sadio Mane – Still doesn’t get the credit he deserves
GROUP F
Inter Milan 20:00 Borussia Dortmund
MATCH ODDS: inter 6/5 Draw 12/5 Dortmund 11/5
BoyleSports pick: Romelu Lukaku to score first @5/1
ANDY SAYS: A great looking game and I think that Inter edge it…2-1
GRAEME SAYS: Could easily be full of goals and I think it ends in a draw…2-2
Football Index – One to follow: Jadon Sancho – One of Europe’s best young players
Slavia Prague 20:00 Barcelona
MATCH ODDS: Slavia 6/1 Draw 15/4 Barcelona 2/5
BoyleSports pick: Barca to win by one goal @14/5
ANDY SAYS: Convincing win for Barca coming up…0-3
GRAEME SAYS: Has to be a Barcelona win and big one at that…0-3
Football Index – One to follow: Frenkie De Jong – Is looking superb already
GROUP G
RB Leipzig 17:55 Zenit St Petersburg
MATCH ODDS: Leipzig 4/7 Draw 10/3 Zenit 4/1
BoyleSports pick: Timo Werner to score first @10/3
ANDY SAYS: Leipzig are an impressive side and I think they get the three points…2-0
GRAEME SAYS: Russian sides don’t tend to travel well and I think Leipzig might edge it…2-1
Football Index – One to follow: Timo Werner – A striker who still has potential to go to the top
Benfica 20:00 Lyon
MATCH ODDS: Benfica 23/20 Draw 5/2 Lyon 11/5
BoyleSports pick: Draw @5/2
ANDY SAYS: Lyon have impressed me and I think they come away with the win here…1-3
GRAEME SAYS: Benfica have been really poor in Europe but I see them bouncing back here…2-1
Football Index – One to follow: Ruben Dias – A gifted central defender who has huge potential
GROUP H
Ajax 17:55 Chelsea
MATCH ODDS: Ajax 13/10 Draw 3/5 Chelsea 19/10
BoyleSports pick: Ajax to win @13/10
ANDY SAYS: Not sure I see Chelsea winning here, but nor do I think they will lose…1-1
GRAEME SAYS: I think Chelsea are playing so well and they take the win here…0-2
Football Index – One to follow: Callum Hudson-Odoi – Possibly the best young player in Europe
Lille 20:00 Valencia
MATCH ODDS: Lille 13/8 Draw 11/5 Valencia 7/4
BoyleSports pick: 1-1 Draw @5/1
ANDY SAYS: Valencia need the win here and they will get it…1-2
GRAEME SAYS: I think that Lille get a point from this one…1-1
Football Index – One to follow: Jonathan Ikone – A huge talent for Lille