Europa League favourites Chelsea and Arsenal look to keep up their perfect starts to their campaigns.
Both Premier League sides have won their opening two games, and they will be looking for a third win as Arsenal travel to Sporting Lisbon and Chelsea host BATE Borisov.
Rangers have also made an impressive start to their Europa League campaign and sit top of Group G and they will stay there with victory over Spartak Moscow at Ibrox.
Celtic are second in Group B and they will be looking for a second win as they travel to Germany to face RB Leipzig.
We run through every game with odds from BoyleSport including a pick from their man Lawrence Lyons and a prediction from our Football Insider Graeme Bailey.
GROUP A
AEK Larnaca 17:55 Ludogorets Razgrad
MATCH ODDS: Larnaca 21/10 Draw 9/4 Ludogorets 13/10
BoyleSports pick: Both Teams To Score @20/23
GRAEME SAYS: Both sides without a win, but am going to go with the home side…2-1
Zurich 17:55 Bayer 04 Leverkusen
MATCH ODDS: Zurich 10/3 Draw 13/5 Bayer 4/5
BoyleSports pick: Both Teams To Score @4/6
GRAEME SAYS: Tough trip for Bayer but see them having the edge…1-2
GROUP B
FC Red Bull Salzburg 17:55 Rosenborg
MATCH ODDS: Red Bull 2/13 Draw 13/2 Rosenborg 16/1
BoyleSports pick: Salzburg & over 2.5 goals @8/15
GRAEME SAYS: Has to be a home win, and a comfortable one…3-0
RB Leipzig 17:55 Celtic
MATCH ODDS: Leipzig 2/5 Draw 15/4 Celtic 6/1
BoyleSports pick: Werner to score first @10/3
GRAEME SAYS: Celtic will put up a good fight, but Leipzig look too strong…2-1
GROUP C
FC Copenhagen 17:55 Slavia Prague
MATCH ODDS: Copenhagen 6/4 Draw 21/10 Slavia 19/10
BoyleSports pick: Copenhagen to win @6/4
GRAEME SAYS: Tough game to call but have to go with Copenhagen…2-0
Zenit St Petersburg 17:55 Bordeaux
MATCH ODDS: Zenit 7/10 Draw 5/2 Bordeaux 4/1
BoyleSports pick: Zenit to win @7/10
GRAEME SAYS: Zenit are strong, they will win this…2-0
GROUP D
RSC Anderlecht 17:55 Fenerbahce
MATCH ODDS: Anderlecht 6/5 Draw 5/2 Fener 2/1
BoyleSports pick: Half Time Draw/Full Time Draw @9/2
GRAEME SAYS: I think Fenerbahce are one of the best teams in this and will win…0-2
Spartak Trnava 17:55 Dinamo Zagreb
MATCH ODDS: Trnava 15/4 Draw 13/5 Zagreb 7/10
BoyleSports pick: Zagreb to win @7/10
GRAEME SAYS: Dinamo I think will get the win here, they have a good squad…0-2
GROUP E
FK Qarabag 17:55 Vorskla Poltava
MATCH ODDS: Qarabag 4/6 Draw 5/2 Vorskla 9/2
BoyleSports pick: Qarabag to win @4/6
GRAEME SAYS: Qarabag will be too strong at home…2-0
Sporting Lisbon 17:55 Arsenal
MATCH ODDS: Sporting 13/5 Draw 9/4 Arsenal Evens
BoyleSports pick: Arsenal to win @Evens
GRAEME SAYS: Arsenal are going through a great patch of form and will win this…0-2
GROUP F
F91 Dudelange 17:55 Olympiakos
MATCH ODDS: Dudelange 9/2 Draw 4/5 Olympiakos 8/13
BoyleSports pick: Olympiakos to win to nil @8/5
GRAEME SAYS: I am not impressed by Olympiakos but think they can win it…0-2
AC Milan 17:55 Real Betis
MATCH ODDS: AC 5/6 Draw 12/5 Real Betis 16/5
BoyleSports pick: Milan to win @5/6
GRAEME SAYS: Milan should have too much but think Betis might snatch a point…1-1
GROUP G
Rangers 20:00 Spartak Moscow
MATCH ODDS: Rangers 23/20 Draw 5/2 Spartak 9/4
BoyleSports pick: Rangers to win @6/5
GRAEME SAYS: Tough game, Spartak are quality but I think Rangers can get something…1-1
Villarreal 20:00 Rapid Vienna
MATCH ODDS: Villarreal 1/3 Draw 4/1 Rapid 8/1
BoyleSports pick: Villarreal to win at Half Time @4/5
GRAEME SAYS: Villarreal are a side with great European pedigree and will win here…3-0
GROUP H
Eintracht Frankfurt 20:00 Apollon Limassol
MATCH ODDS: Frankfurt 4/9 Draw 7/2 Apollon 6/1
BoyleSports pick: Frankfurt Half Time/Full Time @23/20
GRAEME SAYS: Frankfurt
Marseille 20:00 Lazio
MATCH ODDS: Marseille 6/5 Draw 5/2 Lazio 21/10
BoyleSports pick: Draw @5/2
GRAEME SAYS: Quality encounter, two very good teams but have to side with Marseille…2-1
GROUP I
Besiktas 20:00 KRC Genk
MATCH ODDS: Besiktas 11/10 Draw 12/5 Genk 12/5
BoyleSports pick: Besiktas to win @11/10
GRAEME SAYS: A trip to Turkey is always tough – has to be a home win…3-0
Sarpsborg 08 20:00 Malmo FF
MATCH ODDS: Sarpsborg 21/10 Draw 5/2 Malmo 23/20
BoyleSports pick: Score draw @7/2
GRAEME SAYS: Tough call but Malmo have a chance of the away win here…1-2
GROUP J
Sevilla 20:00 Akhisarspor
MATCH ODDS: Sevilla 1/9 8/1 Akhisarspor 18/1
BoyleSports pick: Sevilla -2 @4/5
GRAEME SAYS: Easy home win coming here…4-0
Standard Liege 20:00 FK Krasnodar
MATCH ODDS: Standard 11/8 Draw 13/5 Krasnodar 9/5
BoyleSports pick: Standard to win @11/8
GRAEME SAYS: Tough game for Standard, and I can see them edging it…1-0
GROUP K
FK Jablonec 20:00 FC Astana
MATCH ODDS: Jablonec 11/10 Draw 23/10 Astana 23/10
BoyleSports pick: Astana win and over 1.5 goals @7/2
GRAEME SAYS: Astana have been very good so far and I can see them grabbing the win…0-2
Rennes 20:00 Dynamo Kiev
MATCH ODDS: Rennes 13/10 Draw 21/10 Dynamo 11/5
BoyleSports pick: Both Teams To Score @10/11
GRAEME SAYS: Close call, but can see Rennes sneaking it…3-2
GROUP L
Chelsea 20:00 BATE Borisov
MATCH ODDS: Chelsea 1/8 Draw 13/2 BATE 22/1
BoyleSports pick: Chelsea -2 @11/10
GRAEME SAYS: Just a matter of how many Chelsea win by…3-0
PAOK Salonika 20:00 MOL Vidi
MATCH ODDS: PAOK 1/3 Draw 15/4 MOL 17/2
BoyleSports pick: PAOK to win to nil @21/20
GRAEME SAYS: PAOK will have too much here…2-0