With league leaders Manchester City not playing until Wednesday, second placed Manchester United have the chance to close the gap at the top down to ten points.
United host Burnley at Old Trafford looking for victory, although three points could take them into fifth.
Third placed Chelsea could level with United if they triumph at home to Brighton.
Liverpool host bottom of the table Swansea at Anfield in the final game of the day looking to maintain their grip on fourth place.
If Liverpool do slip-up then Tottenham can leap-frog them if they beat Southampton in the day’s early kick-off.
Bournemouth and West Bromwich Albion could both move out of the relegation places with victories as they host West Ham and Everton respectively.
Under-pressure Stoke boss Mark Hughes is in need of a win as they travel to Huddersfield.
Watford are looking to end a run of four successive games as they host Leicester are Vicarage Road.
See below for a preview on each game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 12:30 Southampton
Wembley Stadium
Live On Sky Sports
TEAM NEWS: Toby Alderweireld and Victor Wanyama are both missing for Tottenham. Southampton have striker Charlie Austin missing with a hamstring injury.
KEY FACT: Spurs are unbeaten in their last 11 Premier League matches played on Boxing Day
MATCH ODDS: Spurs 4/11 Draw 15/4 Southampton 7/1
bet365 Pick: Harry Kane first goal @11/5
ANDY SAYS: You have to go with Spurs getting the three points here…2-0
GRAEME SAYS: I don’t see Southampton getting near Spurs and could be a big home win…4-0
SILKY SAYS: Tottenham looked good at Burnley and they will win easily for me…3-1
FOOTBALLIndex – One to follow: Harry Kane in fine form, and is rightly above £7
AFC Bournemouth 15:00 West Ham United
Vitality Stadium
TEAM NEWS: Jermain Defoe and Junior Stanislas are missing for Bournemouth. Joshua King and Charlie Daniels are also doubts. Manuel Lanzini returns from suspension, whilst Mark Noble is a major doubt.
KEY FACT: West Ham are aiming to win consecutive Premier League away matches for the first time since February
MATCH ODDS: Bournemouth 13/8 Draw 23/10 West Ham 8/5
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: A close game for sure but I have to give Bournemouth the benefit…1-0
GRAEME SAYS: I can see West Ham getting something here, draw for me…1-1
SILKY SAYS: I fancy Bournemouth to take the three points…2-1
FOOTBALLIndex – One to follow: Marko Arnautovic looks good value at just under £1
Chelsea 15:00 Brighton & Hove Albion
Stamford Bridge
TEAM NEWS: Alvaro Morata returns from his suspension, whilst David Luiz and Charly Musonda miss out through injury. Shane Duffy returns after serving his ban, whilst Steve Sidwell remains injured. Izzy Brown is not available to face his parent club.
KEY FACT: Chelsea have won all four of their previous league matches against Brighton
MATCH ODDS: Chelsea 1/6 Draw 11/2 Brighton 16/1
bet365 Pick: Under 2.5 goals @11/10
ANDY SAYS: I have to go with Chelsea win and a pretty straightforward one…4-0
GRAEME SAYS: This might be tougher than some think for Chelsea but they should win…3-1
SILKY SAYS: Comfortable Chelsea win for me, too good for Brighton…4-0
FOOTBALLIndex – One to follow: At £3.18 Alvaro Morata looks a bargain
Huddersfield Town 15:00 Stoke City
John Smith’s Stadium
TEAM NEWS: Huddersfield goalkeeper Jonas Lossl is expected to play despite a broken nose. Elias Kachunga, Philip Billing, Michael Hefele and Jon Gorenc Stankovic. Stoke are without Erik Peters, Bruno Martins Indi and Jese Rodriguez. Glen Johnson remains a doubt.
KEY FACT: Huddersfield are unbeaten in their last five league matches against Stoke
MATCH ODDS: Huddersfield 11/8 Draw 21/10 Stoke 21/10
bet365 Pick: Both Teams To Score @Evens
ANDY SAYS: Home win for me, I think Huddersfield are getting the three points…2-0
GRAEME SAYS: I believe Stoke could get something here, draw for me…2-2
SILKY SAYS: Can see it being close but think Huddersfield will claim the win…2-1
FOOTBALLIndex – One to follow: Aaron Mooy is just outside the top-150 and is one to keep an eye on
Manchester United 15:00 Burnley
Old Trafford
TEAM NEWS: Chris Smalling and Antonio Valencia are both major doubts, whilst Eric Bailly, Michael Carrick and Marouane Fellaini are sidelined. James Tarkowski is banned, whilst Chris Wood and Stephen Ward will be assessed before the game.
KEY FACT: Man Utd have won 19 of their 23 Premier League Boxing Day matches
MATCH ODDS: West Brom 11/2 Draw 3/1 Man Utd 3/5
bet365 Pick: Under 2.5 goals @21/20
ANDY SAYS: I can see this being quite a tough game for United but they should just about do it…2-1
GRAEME SAYS: I would not rule out Burnley getting something here…2-2
SILKY SAYS: Easy home win for me, I think United will be too strong…3-0
FOOTBALLIndex – One to follow: David De Gea under £1 and outside top-200, surely under-rated
Watford 15:00 Leicester City
Vicarage Road
TEAM NEWS: Watford have Abdoulaye Doucoure and Marvin Zeegelaar available after suspension but Troy Deeney is still banned. Will Hughes and Isaac Success are both sidelined. Daniel Amartey is suspended whilst Danny Simpson is a major doubt.
KEY FACT: Leicester have only won one of their 11 Premier League matches played on Boxing Day
MATCH ODDS: Watford 11/8 Draw 12/5 Leicester 15/8
bet365 Pick: Over 2.5 goals @4/5
ANDY SAYS: I am going with Watford just to edge the win here…1-0
GRAEME SAYS: Leicester are playing well and I think they might just sneak this one…1-2
SILKY SAYS: This is a close game, can see it being a score draw…1-1
FOOTBALLIndex – One to follow: Jamie Vardy is a bargain at 78p
West Bromwich Albion 15:00 Everton
The Hawthorns
TEAM NEWS: Matt Phillips could make the game but Nacer Chadli and James Morrison remain sidelined. Wayne Rooney is expected to be fit despite suffering with flu, but Idrissa Gueye is a major doubt.
KEY FACT: West Bromwich Albion have lost each of their last three Boxing Day league matches in league competition
MATCH ODDS: West Brom 29/20 Draw 21/10 Everton 2/1
bet365 Pick: Everton Draw No Bet @11/10
ANDY SAYS: Everton win here, quite comfortable too…0-2
GRAEME SAYS: Tough one but I will give West Brom the benefit and say they can get a point…1-1
SILKY SAYS: Close game but I think Everton have enough to take the win…1-2
FOOTBALLIndex – One to follow: Wayne Rooney just inside the top-100 at just over £1.50
Liverpool 17:30 Swansea City
Anfield
Live On Sky Sports
TEAM NEWS: Joel Matip could return for Liverpool but captain Jordan Henderson is sidelined. Kyle Naughton is set to miss out – whilst there is a doubt over Leroy Fer.
KEY FACT: Liverpool have not lost a home league match on Boxing Day since 1986
MATCH ODDS: Liverpool 1/7 Draw 13/2 Swansea 16/1
bet365 Pick: Liverpool to win & Both Teams To Score @13/8
ANDY SAYS: Comfortable home win, don’t see Swansea getting anything…4-0
GRAEME SAYS: West Brom drew at Anfield so Swansea could, but they won’t…4-0
SILKY SAYS: Could be a huge score, big win coming for Liverpool…5-0
FOOTBALLIndex – One to follow: Number five in the Index – Philippe Coutinho is still one to watch