The top-seven are all in action on Saturday as leaders Manchester City could see their lead extended to more than ten points at the top.
City, who have an eight-point lead at the top, travel to Leicester looking to maintain their unbeaten start to the season.
Second placed Man United finish off the day when they host Newcastle United at Old Trafford.
The pick of the weekend’s fixtures comes with the opening game with the North London derby, as Tottenham make the short trip to across the capital to the Emirates.
Chelsea could move into second with victory, and they take on West Brom at The Hawthorns.
Liverpool are hoping to close the gap on the top-four as they entertain Southampton at Anfield.
Seventh placed Burnley hope they can maintain their excellent start to the season as they host second-from-bottom Swansea.
Bottom-of-the-table Crystal Palace are looking for only their second win of the season as they host Everton – still under interim boss David Unsworth.
Finally, Bournemouth are hosting Huddersfield at the Vitality Stadium.
See below for a run-down on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, leading agent Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Arsenal 12:30 Spurs
Live On Sky Sports
TEAM NEWS: Olivier Giroud is set to miss out for the home side, whist Shkodran Mustafi and Danny Welbeck are rated at 50/50. Tottenham defender Toby Alderweireld until the New Year, whilst Victor Wanyama remains sidelined.
KEY FACT: Harry Kane has scored in all five of his PL North London derbies
MATCH ODDS: Arsenal 13/10 Draw 5/2 Spurs 15/8
bet365 Pick: Spurs Draw No Bet @ Evens
ANDY SAYS: A close one, but have to think this will end in a draw…1-1
GRAEME SAYS: This has all the makings of being a classic and I am just going with Spurs…0-2
SILKY SAYS: Good game this one, for sure but I think Arsenal could get the job done…2-1
FOOTBALLIndex – One to follow: Harry Kane is second on the INDEX, and rightly so
Bournemouth 15:00 Huddersfield
TEAM NEWS: Christopher Schindler is suspended for Huddersfield, whilst Kasey Palmer, Michael Hefele, Jon Stankovic and Philip Billing are all sidelined. Benik Afobe, Tyrone Mings and Junior Stanislas are all doubts for the away side.
KEY FACT: Huddersfield have won only one of their last 10 meetings in all competitions with Bournemouth
MATCH ODDS: Bournemouth 4/5 Draw 12/5 Huddersfield 15/4
bet365 Pick: Goal before 32 mins @5/6
ANDY SAYS: Bournemouth need a win here and I think they will get the three points…2-0
GRAEME SAYS: I think Bournemouth will just about have enough, but could go either way…2-1
SILKY SAYS: Close call, I can see Huddersfield getting a point…1-1
FOOTBALLIndex – One to follow: Jermain Defoe at under £1 is surely ready to perform
Burnley 15:00 Swansea
TEAM NEWS: Kyle Bartley is the only player definitely missing for Swansea but Martin Olsson, Wilfried Boney and Renato Sanches are all in contention. Burnley are sweating over the fitness of striker Chris Wood, who is returning from his around the world trip with New Zealand.
KEY FACT: Swansea City have won all four of their Premier League meetings with Burnley
MATCH ODDS: Burnley 21/20 Draw 9/4 Swansea 11/4
bet365 Pick: Swansea double chance @4/5
ANDY SAYS: Have to go with Burnley claim a narrow home win…1-0
GRAEME SAYS: I can see Swansea maybe getting a point here, but won’t be easy…1-1
SILKY SAYS: Burnley will edge out Swansea here for me and take the three points…1-0
FOOTBALLIndex – One to follow: Tammy Abraham looks a decent buy at around £1.20
Crystal Palace 15:00 Everton
TEAM NEWS: Christian Benteke is back in training, but won’t be available for this match. Ruben Loftus-Cheek and Patrick van Aanholt are set to miss out. Tom Davies has joined the Everton injury list whilst James McCarthy, Ross Barkley and Seamus Coleman are back in light training. Ramiro Funes Mori, Yannick Bolasie and Cuco Martina are all sidelined.
KEY FACT: If Crystal Palace lose then they will equal Everton and QPR’s record for fewest points after 12 matches of a PL season
MATCH ODDS: Palace 7/5 Draw 9/4 Everton 23/10
bet365 Pick: Both Teams to Score @ 19/20
ANDY SAYS: I have to go with my former team in this one, I think they will win…2-0
GRAEME SAYS: Two very unpredictable teams but think Palace will sneak it…2-1
SILKY SAYS: Can see goals, but think it will be a draw…2-2
FOOTBALLIndex – One to follow: At £1.61, Ruben Loftus-Cheek has soared in price
Leicester 15:00 Man City
King Power Stadium
TEAM NEWS: City will check on Sergio Aguero, Raheem Sterling, Fabian Delph and Vincent Kompany before kick-off but Benjamin Mendy is sidelined and Nicolas Otamendi suspended. Robert Huth and Matty James are ruled out and Ben Chilwell is a doubt.
KEY FACT: Leicester have won two of their last three Premier League meetings with Man City
MATCH ODDS: Leicester 17/2 Draw 19/4 Man City 1/3
bet365 Pick: Leicester to score first @3/1
ANDY SAYS: Comfortable win here for Man City, they are getting the three points…1-4
GRAEME SAYS: I have to go with the visitors but don’t think it will be a walk-over…0-2
SILKY SAYS: Man City are going to win this, it is just a matter of by how many…1-4
FOOTBALLIndex – One to follow: Kevin De Bruyne at just £4 – wow, what a bargain
Liverpool 15:00 Southampton
TEAM NEWS: Philippe Coutinho should return for Liverpool, but Jordan Henderson is a doubt. Adam Lallana and Nathaniel Clyne remain sidelined. Mario Lemina and Jeremy Pied are sidelined for Southampton.
KEY FACT: Liverpool have lost only two of their last 32 Premier League matches at Anfield
MATCH ODDS: Liverpool 2/5 Draw 4/1 Southampton 8/1
bet365 Pick: Half Time Draw/ Full time Liverpool @ 3/1
ANDY SAYS: I am not convinced by Liverpool, think Southampton will take something…1-1
GRAEME SAYS: I don’t see Liverpool not winning this, I think it will be a convincing win…3-0
SILKY SAYS: I think Liverpool will have too much for Southampton…2-0
FOOTBALLIndex – One to follow: Mo Salah at just over £2.50 looks great value
West Brom 15:00 Chelsea
TEAM NEWS: Tiemoue Bakayoko, Michy Batshuayi and Gary Cahill are all doubts for Chelsea. Craig Dawson and James Morrison are still sidelined for West Brom.
KEY FACT: Alvaro Morata has been directly involved in 10 goals in his first 10 PL matches for Chelsea
MATCH ODDS: West Brom 11/2 Draw 3/1 Chelsea 8/13
bet365 Pick: West Brom win @ 11/2
ANDY SAYS: Chelsea all the way, comfortable win for them here…0-3
GRAEME SAYS: Like every game at The Hawthorns, this won’t be easy for Chelsea, but they should win…1-2
SILKY SAYS: I think Chelsea will be too good here, don’t see West Brom troubling them…0-3
FOOTBALLIndex – One to follow: Eden Hazard not in the top-ten, what a bargain
Man Utd 17:30 Newcastle
Live On BT Sport
TEAM NEWS: Phil Jones is hoping to make the game, but Marcos Rojo, Michael Carrick, Zlatan Ibrahimovic and Paul Pogba are still out. Christian Atsu, Jamaal Lascelles and Mikel Merino are all doubtful for the visitors, whilst Paul Dummett is back in training.
KEY FACT: Man Utd have lost only one of their last 32 league matches against Newcastle at Old Trafford
MATCH ODDS: Man Utd 3/10 Draw 19/4 Newcastle 11/1
bet365 Pick: Goal after 73:59 @ 5/6
ANDY SAYS: Man Utd will have enough to claim the three points…2-0
GRAEME SAYS: I don’t see how Newcastle get something from this…3-1
SILKY SAYS: Comfortable home win for Man Utd, home win…4-0
FOOTBALLIndex – One to follow: Romelu Lukaku is back under £5, represents very good value