Liverpool and Chelsea look to maintain their 100% Premier League records on Saturday.
Liverpool put their record on the line first as they kick-off the weekend’s action as they face a tricky looking trip to Leicester.
Chelsea look for a fourth successive win at Stamford Bridge as they entertain Bournemouth – who themselves are yet to be beaten.
Champions Manchester City dropped their first points at newly promoted Wolves last week, but they are looking to get back to winning ways against thus far win-less Newcastle.
Bottom of the table West Ham are looking for their first points as they host they aforementioned Wolves at the London Stadium.
Huddersfield, who have just one point to their name, face a trip to Everton whilst Southampton – another side without a win – travel to Crystal Palace.
Finally, Brighton welcome Fulham to the Amex – both with three points to their name thus far.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Leicester City 12:30 Liverpool
King Power Stadium
TEAM NEWS: Leicester are without Jamie Vardy through suspension whilst Matty James remains sidelined.Summer signing Caglar Soyuncu remains short of fitness.
Dejan Lovren is still short of fitness and will not appear, whilst Alex Oxlade-Chamberlain is a long-term absentee.
KEY FACT: Liverpool are looking to win their opening four matches of a Premier League season for the first time
MATCH ODDS: Leicester 6/1 Draw 15/4 Liverpool 2/5
bet365 Pick: Under 2.5 goals 6/5
ANDY SAYS: Liverpool have been so good so far this season, don’t see how they will not be leaving Leicester with all three points…0-3
GRAEME SAYS: Liverpool have been wonderful, but Leicester have not been too bad and they could very get a point here…1-1
Football Index – One to follow: Harry Maguire – is on the rise in real life and on the Index
Brighton & Hove Albion 15:00 Fulham
Amex Stadium
TEAM NEWS: Bruno and Lewis Dunk should both be available for Brighton but Florin Andone and Jose Izquierdo are definitely out.
Alfie Mawson could make his Fulham debut but captain Tom Cairney has joined Floyd Ayite, Neeskens Kebano and Tim Ream on the sidelines.
KEY FACT: Brighton have only ever lost one Premier League match in September
MATCH ODDS: Brighton 6/5 Draw 23/10 Fulham 23/10
bet365 Pick: Under 2.5 goals 9/10
ANDY SAYS: Tough one to call, and I see goals – but I think Fulham have got themselves together now and will come out on top with a narrow win…1-2
GRAEME SAYS: Fulham sealed their first win last week, but I am not sure they are going to make it back-to-back successes, and I can see Brighton claiming it…2-0
Football Index – One to follow: Jean Michael Seri – great opening goal, one to watch for sure
Chelsea 15:00 AFC Bournemouth
Stamford Bridge
TEAM NEWS: Willian could return for Chelsea, but Cesc Fabregas remains sidelined.
Bournemouth’s record signing Jefferson Lerma is set to make his debut, whilst Adam Smith is back from suspension. Lys Mousset and Marc Pugh are doubts.
KEY FACT: Over the last three seasons, no side have beaten Chelsea at Stamford Bridge more often in the league than Bournemouth
MATCH ODDS: Chelsea 2/7 Draw 19/4 Bournemouth 8/1
bet365 Pick: Chelsea win & Both Teams To Score 6/4
ANDY SAYS: A see goals in this one for sure, I love how Chelsea have been playing and I believe they will win…3-2
GRAEME SAYS: I don’t see Bournemouth getting close to Chelsea – The Blues have been great, and will maintain their 100% record here…2-0
Football Index – One to follow: Jorginho – has started well for Chelsea, very much one to watch
Crystal Palace 15:00 Southampton
Selhurst Park
TEAM NEWS: The only injury issues for Southampton is Danny Ings, but he is back in training and should feature. Pierre-Emile Hojbjerg returns from suspension.
Aaron Wan-Bissaka is back after suspension for Crystal Palace, whilst James Tomkins and Pape Souare are set to return.
KEY FACT: Roy Hodgson has only lost one of his seven managerial encounters with Mark Hughes
MATCH ODDS: Palace 19/20 Draw 5/2 Southampton 14/5
bet365 Pick: Draw 5/2
ANDY SAYS: I am going with my former club here, comfortable win – Roy has got the boys playing well, carrying on from last term…3-1
GRAEME SAYS: Southampton are not great, I don’t see how they get anything here so has to be a home win…2-0
Football Index – One to follow:Andros Townsend – has started the season well, very much one to keep an eye on
Everton 15:00 Huddersfield Town
Goodison Park
TEAM NEWS: Phil Jagielka, Idrissa Gueye and Bernard are all ruled out whilst Richarlison is suspended. Ademola Lookman is in contention to feature.
Goalkeeper Ben Hamer is a doubt for Huddersfield. Midfielder Jonathan Hogg is suspended.
KEY FACT: Huddersfield are looking for their first win at Everton in 15 attempts
MATCH ODDS: Everton 1/2 Draw 3/1 Huddersfield 6/1
bet365 Pick: Both Teams Not To Score 4/6
ANDY SAYS: Has to be an Everton win, I thought from the start of the season that Huddersfield would be going down and I haven’t seen anything to change my mind…2-0
GRAEME SAYS: Huddersfield need a good performance here, I am just not sure they are going to get it as Everton will surely get the victory…3-1
Football Index – One to follow:Theo Walcott – has begun the season in superb form, and could be an interesting option on the Index
West Ham United 15:00 Wolverhampton Wanderers
London Stadium
TEAM NEWS: Marko Arnautovic has overcome a knee issue and will be fit, but Andy Carroll, Manuel Lanzini and Winston Reid remain sidelined.
Wolves’ only absentee is Ivan Cavaleiro – whist club record signing Adama Traore could be handed a full debut.
KEY FACT: This will be the first Premier League meeting between West Ham and Wolves since 2011
MATCH ODDS: West Ham 6/4 Draw 23/10 Wolves 9/5
bet365 Pick: Both Teams To Score 4/6
ANDY SAYS: This looks a good clash, I can see Wolves getting something but maybe not quite victory…1-1
GRAEME SAYS: I think Wolves could get the win here, West Ham have been really poor and I think their misery will continue…1-2
Football Index – One to follow:Douglas Costa – has started the season well and one of a number of Wolves players that you should be looking at
Man City 17:30 Newcastle
Etihad Stadium
TEAM NEWS: City remain without injured quartert Kevin de Bruyne, Danilo, Claudio Bravo and Equalim Mangala.
Isaac Hayden remain suspended for Newcastle, whilst captain Jamaal Lascelles is a doublt with an ankle problem but Kenedy is available again.
KEY FACT: Newcastle are looking for their first point in 10 trips to the Etihad
MATCH ODDS: Man City 1/10 Draw 8/1 Newcastle 20/1
bet365 Pick: Aguero over 1.5 shots on target 4/6
ANDY SAYS: Newcastle are not going to get anything here, it is a simple as that – City win…3-0
GRAEME SAYS: Rafa Benitez will park the bus, but it is still a matter of how many will City score…5-0
Football Index – One to follow:Raheem Sterling – has carried on from where he left off last season, get on him