All eyes remain on Manchester City, Liverpool and Chelsea as the Premier League returns to action following the international break.
The top-three remain unbeaten, and all are in action on Saturday, and all three face tricky away tests in the capital.
Leaders Manchester City travel to the London Stadium, whilst second placed Liverpool are at Vicrage Road to face Watford.
But the undoubted game of the weekend is at Wembley, as Chelsea come up against fourth-placed Tottenham in one of the matches of the season so far.
Manchester United are looking to bounce back from their derby defeat to City last time out, and victory over Crystal Palace at Old Trafford could take them back up to sixth in the table.
At the other end of the table, there is a huge game at Craven Cottage, which is an archetypal ‘six-pointer’. Claudio Ranieri takes charge of bottom-of-the-table Fulham for the first time since replacing Slavisa Jokanovic and he comes up against Mark Hughes and Southampton – who are just three points better off.
Elsewhere, ninth-placed Everton host Cardiff City whilst Brighton entertain Leicester at the AMEX.
See below for a preview on the game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Brighton & Hove Albion 15:00 Leicester City
AMEX Stadium
TEAM NEWS: Brighton are without the suspended Dale Stephens, whilst they could have a near fully fit squad with Davy Propper, Pascal Gross, David Button and Alireza Jahanbakhsh all hoping to return from injury.
Leicester are without Daniel Amartey and Matty James, whilst Harry Maguire and James Maddison remain major doubts.
KEY FACT: Leicester won both of last season’s Premier League meetings with Brighton 2-0
MATCH ODDS: Brighton 9/5 Draw 11/5 Leicester 6/4
bet365 Pick: Draw & Under 2.5 goals @11/4
ANDY SAYS: Close game but would have to give Leicester the edge here and just about taking the win…1-2
GRAEME SAYS: I think Brighton have got enough to get something at home, so going with a draw…1-1
Football Index – One to follow: James Maddison – hugely impressive figure, who could go on to achieve big things
Everton 15:00 Cardiff City
Goodison Park
TEAM NEWS: Everton should have Ademola Lookman, Jonjoe Kenny and Andre Gomes available, but Gylfi Sigurdsson remains a major doubt.
Cardiff should have Jazz Richards and Sean Morrison available again, but the game comes too early for Nathaniel Mendez-Laing – although he is back in training. Kenneth Zohore may undergo a late test.
KEY FACT:Everton are unbeaten in their last eight top-flight home matches against Cardiff
MATCH ODDS: Everton 2/5 Draw 15/4 Cardiff 13/2
bet365 Pick: Everton win & under 2.5 goals @12/5
ANDY SAYS: Comfortable home win for Everton, as I have said before not too impressed by Cardiff…3-1
GRAEME SAYS: Tough trip for Cardiff here and don’t see them taking anything from Goodison…2-0
Football Index – One to follow: Richarlison – what a player this boy is becoming, need to get on him sooner rather than later
Fulham 15:00 Southampton
Craven Cottage
TEAM NEWS: Claudio Ranieri could have the luxury of a fully fit squad for his first game with the only doubts being Kevin McDonald and Joe Bryan.
Shane Long is sidelined for Southampton, and both Danny Ings and Mario Lemina are major doubts for Mark Hughes. Ryan Bertrand is suspended.
KEY FACT: Fulham, who have lost their last six league matches, have not lost seven in succession since 1962.
MATCH ODDS: Fulham 31/20 Draw 11/5 Southampton 9/5
bet365 Pick: Fulham win @32/20
ANDY SAYS: I can see the Ranieri effect getting Fulham the three points they desperately need here…2-1
GRAEME SAYS: A real relegation scrap coming up here, but I see goals and Fullham edging it…3-2
Football Index – One to follow: Ryan Sessegnon – still a player with so much to offer, one to be on for sure
Manchester United 15:00 Crystal Palace
Old Trafford
TEAM NEWS: Luke Shaw is suspended for United, but Jose Mourinho could name a near fully fit squad as they hope Paul Pogba, Romelu Lukaku, Marcus Rashford, Eric Bailly, Anthony Martial, Marouane Fellaini and Diogo Dalot could be available.
Palace are hoping that star turn Wilfried Zaha could feature, but he remains a major doubt – likewise Mamadou Sakho and Aaron Wan-Bissaka could feature, but James Tomkins, Connor Wickham, Scott Dann and Christian Benteke.
KEY FACT: Man United have played Palace 18 times in the Premier League – but have never lost.
MATCH ODDS: Man Utd 4/11 Draw 4/1 Palace 13/2
bet365 Pick: Man Utd win & Both Teams To Score @21/10
ANDY SAYS: I think this will be a good game, I can see Palace performing well but United just to edge it…3-2
GRAEME SAYS: Tough ask for Palace here, and I have to go with United…2-0
Football Index – One to follow: Wilfried Zaha – has so much potential on the Index
Watford 15:00 Liverpool
Vicarage Road
TEAM NEWS: Alex Oxlade-Chamberlain is the only long-term absentee for Liverpool, and him aside it could be a full squad for Jurgen Klopp to choose from with the only other doubt being Jordan Henderson.
Watford have Venezuelan Adalberto Penaranda available after he landed his work-permit, but is unlikely to be involved. Tom Cleverley is sidelined until next month, Daryl Janmaat, Sebastian Prodl and Will Hughes could feature.
KEY FACT:There has never been a goalless draw in the 22 top-flight meetings between Watford and Liverpool
MATCH ODDS: Watford 11/2 Draw 16/5 Liverpool 1/2
bet365 Pick: Draw @16/5
ANDY SAYS: Comfortable away win, don’t see Liverpool not being troubled here…1-4
GRAEME SAYS: Won’t be too easy for Liverpool, and I can see Watford holding them…1-1
Football Index – One to follow: Mo Salah – he is yet to hit his straps this season, but could unleash some top displays anytime soon
West Ham United 15:00 Manchester City
The London Stadium
TEAM NEWS: Ryan Fredericks has joined Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini. Jack Wilshere is now back in training, but won’t be involved by Andy Carroll could make his return to the bench. Robert Snodgrass is suspended.
Bernardo Silva, Benjamin Mendy and Nicolas Otamendi have joined an ever increasing injury list at City, that already boasts Kevin De Bruyne, Claudio Bravo and Eliaquim Mangala.
KEY FACT: West Ham are looking to secure a second consecutive home league win for the first time since December 2016
MATCH ODDS: West Ham 12/1 Draw 5/1 Man City 2/9
bet365 Pick: Man City win & over 3.5 goals @ 13/10
ANDY SAYS: Has to be a City win, West Ham just aren’t good enough…0-3
GRAEME SAYS: West Ham could put up a good fight here, but has to be City with the win…0-2
Football Index – One to follow: Raheem Sterling – has the potential to be one of the top players on the Index
Tottenham Hotspur 17:30 Chelsea
Wembley Stadium
TEAM NEWS: Jan Vertonghen could return for Tottenham but they are without Davinson Sanchez, Kieran Trippier, Moussa Dembele Danny Rose and Vincent Janssen.
Mateo Kovacic and Ethan Ampadu are both doubts for Chelsea, but Maurizio Sarri has a near fully fit squad to choose from.
KEY FACT: Dele Alli has scored five goals in his last four matches against Chelsea in all competitions
MATCH ODDS: Spurs 17/10 Draw 12/5 Chelsea 6/4
bet365 Pick: Draw @12/5
ANDY SAYS: Tough game to call, but this could be a cracker but I have to go for a draw…1-1
GRAEME SAYS: I think that Spurs could grab a win here and inflict Chelsea’s first defeat…2-1
Football Index – One to follow: Eden Hazard – until he is number one, there is still some value
