Leaders Manchester City will go five points clear at the top of the Premier League with victory on Saturday.
City – the only team in the top-six who are playing – host Bournemouth at The Etihad.
Manchester United could move up to sixth in the table as they to lowly Southampton – whose boss Mark Hughes is odds-on favourite to be the next top-flight boss to lose his job.
Newcastle United are looking for a fourth successive win as they host West Ham at St James’ Park. The two clubs are level on 12-points apiece.
Ninth plays tenth at the King Power as Leicester host Watford, whilst Huddersfield welcome Brighton to Yorkshire and the John Smith’s Stadium.
The final game sees Crystal Palace and Burnley – both just a point above the bottom-three – face each other at Selhurst Park.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Crystal Palace 15:00 Burnley
Selhurst Park
TEAM NEWS: Burnley’s Johann Berg Gudmondsson has recovered from sickness, while James Tarkowski and Ben Gibson are back in contention after hernia surgery.
Connor Wickham and Scott Dann are back in training for Palace, but Christian Benteke remains sidelined.
KEY FACT: Newcastle are yet to win a league match away from home this season
MATCH ODDS: Crystal Palace 6/4 Draw 2/1 Burnley 12/5
bet365 Pick: Palace to win & Over 2.5 goals @7/4
ANDY SAYS: I am going for my old team to come out on top…2-0
GRAEME SAYS: Burnley are playing really poor, I don’t see how they get anything here…3-1
Football Index – One to follow: Aaron Wan-Bissaka – hugely talented defender, could be a
Huddersfield Town 15:00 Brighton & Hove Albion
John Smith’s Stadium
TEAM NEWS: Chris Lowe and Laurent Depoitre are both sidelined for Huddersfield, whilst Terence Kongolo is 50/50 but Zanka is back from suspension.
Alireza Jahanbakhsh remains out for Brighton, while Dale Stephens continues his suspension.
KEY FACT: Six of the last 10 league meetings between Huddersfield and Brighton have ended as draws
MATCH ODDS: Huddersfield 6/4 Draw 2/1 Brighton 12/5
bet365 Pick: Steve Mounie anytime @9/4
ANDY SAYS: I can see Huddersfield claiming the win here, a big victory they need…2-1
GRAEME SAYS: Tough one here, but Brighton are a good team and I can see them getting at least a point…2-2
Football Index – One to follow: Steve Mounie – still a fine prospect, and well worth a look at
Leicester City 15:00 Watford
King Power Stadium
TEAM NEWS: Leicester are waiting on Vicente Iborra and Racid Ghezzal, but they are without Harry Maguire, Matty James and Daniel Amartey.
Watford could welcome back Jose Holebas, but Tom Cleverley, Daryl Janmaat and Adalberto Penaranda are sidelined.
KEY FACT: Leicester have won all four of their Premier League home matches against Watford
MATCH ODDS: Leicester 5/4 Draw 23/10 Watford 13/5
bet365 Pick: Under 2.5 goals @10/11
ANDY SAYS: Two good teams going at it here, and I can’t separate them, has to be a draw…1-1
GRAEME SAYS: Has to be a home win for me, I think Leicester will be too strong…2-0
Football Index – One to follow: Demarai Gray – a huge talent, could be a transfer target very soon
Manchester City 15:00 AFC Bournemouth
Etihad Stadium
TEAM NEWS: Jefferson Lerma is suspended for Bournemouth, who are without Adam Smith and Dan Gosling.
City could welcome back Bernardo Silva, but they have a lengthy absentee list with Gabriel Jesus, Ilkay Gundogan, Benjamin Mendy, Kevin De Bruyne, Claudio Bravo and Eliaquim Mangala.
KEY FACT: Man City have won all six of their Premier League matches against Bournemouth
MATCH ODDS: Man City 1/9 Draw 10/1 Bournemouth 25/1
bet365 Pick: Raheem Sterling First Goal – Each Way @9/2
ANDY SAYS: Comfortable City win, little doubt about it…4-1
GRAEME SAYS: Bournemouth are a decent team – but they won’t get anything here…2-0
Football Index – One to follow: Leroy Sane – a terrific young player with plenty of value remaining in him
Newcastle United 15:00 West Ham United
St. James’ Park
TEAM NEWS:Marko Arnautovic, Jack Wilshere and Andy Carroll are all fit, but Winston Reid, Manuel Lanzini, Carlos Sanchez and Ryan Fredericks remain sidelined.
Newcastle left-back Paul Dummett misses out after sustaining a calf problem playing for Wales.
Jamaal Lascelles and Yoshinori Muto will have late fitness tests, but Paul Dummett remains sidelined along with Florian Lejuene.
KEY FACT: Newcastle have won their last three league matches against West Ham
MATCH ODDS: Newcastle 6/4 23/10 21/10
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: Newcastle have been playing well and they will probably win here…2-1
GRAEME SAYS: I can see West Ham getting something, with Andy Carroll getting involved…2-2
Football Index – One to follow: Jack Wilshere – surely there is still time for Jack to come good
Southampton 17:30 Man Utd
St. Mary’s Stadium
TEAM NEWS: Southampton are without strikers Danny Ings and Shane Long, whilst Ryan Bertrand is a doubt.
Alexis Sanchez has joined Victor Lindelof and Matteo Darmian on the sidelines, but Diogo Dalot and Marcos Rojo could return.
KEY FACT: Southampton have not beaten Manchester United since 2003
MATCH ODDS: Southampton 7/2 Draw 13/5 Man Utd 10/11
bet365 Pick: Draw @13/5
ANDY SAYS: I think that another United horror show is coming and Southampton win…1-0
GRAEME SAYS: United will get the three points, but it won’t be easy…0-2
Football Index – One to follow: Marcus Rashford – needs to bounce back, but he still well worth a look
