Defending champions Manchester City are the main draws on Saturday as they look to keep pace with Liverpool.
City’s final home game of 2018 sees them host Crystal Palace – who are looking for back-to-back wins after victory last time out.
Chelsea have the chance to move into third as they face Leicester at Stamford Bridge, with question marks being raised over the future of Foxes chief Claude Puel.
Should Chelsea lose, then that would give Arsenal the chance to leap into the top-four with victory over Burnley in North London.
Interim Manchester United boss Ole Gunnar Solskjaer takes charge of his first game against his former club Cardiff City.
Bottom of the table Fulham have the chance to move of the foot before Christmas Day, but they need to win at Newcastle and then hope Huddersfield don’t win their big clash with relegation rivals Southampton.
The final two games on Saturday are derby clashes. There is a South Coast clash between Bournemouth and Brighton – whilst there is a capital clash at the London Stadium as in-form West Ham host Watford.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Arsenal 12:30 Burnley
Emirates Stadium
TEAM NEWS: Hector Bellerin, Rob Holding, Konstantinos Mavropanos and Danny Welbeck are all sidelined for Arsenal, but they hope Sead Kolasinac and Shkodran Mustafi will be fit.
Burnley hope to have Robbie Brady, Johan Gudmundsson and Steven Defour available, but Aaron Lennon and Stephen Ward are ruled out.
KEY FACT: Brighton are yet to beat Bournemouth in the Premier League
MATCH ODDS: Arsenal 1/4 Draw 11/2 Burnley 14/1
bet365 Pick: Arsenal to win & Under 3.5 goals @6/5
ANDY SAYS: Arsenal will deal with Burnley here, won’t be a huge issue…2-0
GRAEME SAYS: Comfortable home win, little doubt about it…3-0
Football Index – One to follow: Aaron Ramsey – set to leave this summer and could very well be heading for a top club
AFC Bournemouth 15:00 Brighton & Hove Albion
Vitality Stadium
TEAM NEWS: Dan Golsing – along with long-term absentees Adam Smith and Lewis Cook are unavailable for Bournemouth but they hope Simon Francis will be available.
Jose Izquierdo and Alireza Jahanbakhsh both remain sidelined for Brighton, whilst Shane Duffy is suspended.
KEY FACT: Bournemouth are yet to lose to Brighton in the Premier League
MATCH ODDS: Bournemouth 10/11 Draw 13/5 Brighton 7/2
bet365 Pick: Bournemouth to win @10/11
ANDY SAYS: Close one to call here, two decent teams and I think Brighton will just have enough to claim a point…1-1
GRAEME SAYS: I think Bournemouth being at home will give them the edge here, but will be close…2-1
Football Index – One to follow: Callum Wilson – an outstanding talent, very much one to watch
Chelsea 15:00 Leicester City
Stamford Bridge
TEAM NEWS: Alvaro Morata, Victor Moses and Andreas Christensen all miss out for Chelsea.
Wilfried Ndidi, Jamie Vardy and Matty James could be available for Leicester but Ben Chilwell and Daniel Amartey are sidelined.
KEY FACT: Chelsea have lost only once in their last 12 league meetings with Leicester City
MATCH ODDS: Chelsea 1/3 Draw 9/2 Leicester 10/1
bet365 Pick: Draw Half Time/Chelsea Full Time @11/4
ANDY SAYS: Leicester are not playing well, Chelsea will grab the win…2-0
GRAEME SAYS: I don’t see how Leicester get anything from this, home win – and a good one…3-0
Football Index – One to follow: Eden Hazard – world class performer and still offers value
Huddersfield Town 15:00 Southampton
John Smith’s Stadium
TEAM NEWS: Huddersfield hope to have Rajiv van la Parra available but Danny Williams Tommy Smith, Aaron Mooy and Adbelhamid Sabiri are out.
Nathan Redmond, Mario Lemina, Jack Stephens, Cedric and Michael Obafemi are all rated doubtful, but Ryan Bertrand won’t make it.
KEY FACT: Huddersfield are unbeaten in their last three home matches against Southampton
MATCH ODDS: Huddersfield 21/10 Draw 21/10 Southampton 8/5
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: Big game for both clubs, can see them cancelling each other out so draw for me…1-1
GRAEME SAYS: This would be a huge three points for both teams, I think Southampton grab a big win…0-2
Football Index – One to follow: Mario Lemina – play for a top-six side, plenty of value in him
Manchester City 15:00 Crystal Palace
Etihad Stadium
TEAM NEWS: Captain Vincent Kompany and Danilo could return for City, but David Silva, Benjamin Mendy, Claudio Bravo and Eliaquim Mangala will be sidelined.
Palace are without Christian Benteke, but they hope that goalkeeper Wayne Hennessey and Cheikhou Kouyate will be available.
KEY FACT: City have won all nine of their home games so far this season
MATCH ODDS: Man City 1/7 Draw 9/1 Palace 20/1
bet365 Pick: Man City to win & Both Teams To Score @6/4
ANDY SAYS: As much as I would love my former team to do something, City are going to win here…4-0
GRAEME SAYS: City will have far too much for Palace here…3-0
Football Index – One to follow: Leroy Sane – still plenty of value in the young German
Newcastle United 15:00 Fulham
St. James’ Park
TEAM NEWS: Maxime Le Marchand and Kevin McDonald should be available, but Andre-Frank Zambo Anguissa and Ryan Sessegnon are set to miss out.
Kendey and Jonjo Shelvey are both set to miss out, as is Florian Lejuene – but he is now back in training. Federico Fernandez and Karl Darlow could return.
KEY FACT: Newcastle manager Rafa Benitez has yet to lose a home PL match against Fulham
MATCH ODDS: Newcastle Evens Draw 13/5 Fulham 3/1
bet365 Pick: Under 2.5 goals @Evens
ANDY SAYS: Fulham really are struggling at the moment, has to be a Newcastle victory…2-0
GRAEME SAYS: Don’t see Newcastle now claiming the win here, and my some distance…3-1
Football Index – One to follow: Aleksandar Mitrovic – facing his former club, he still has real value in him
West Ham United 15:00 Watford
London Stadium
TEAM NEWS: Lucas Perez will return for West Ham butRyan Fredericks, Manuel Lanzini, Jack Wilshere, Andriy Yarmolenko, Winston Reid, Carlos Sanchez and Marko Arnautovic are all ruled out.
Daryl Janmaat should be available for Watford along with Adalberto Penaranda, but Will Hughes, Andre Gray and Sebastian Prodl are out.
KEY FACT: West Ham are looking to win five Premier League matches in a row for the first time since February 2006
MATCH ODDS: West Ham 11/8 Draw 5/2 Watford 21/10
bet365 Pick: West Ham win @11/8
ANDY SAYS: The Hammers are really in form, has to be a home win but will be a good game…2-1
GRAEME SAYS: Tough one to call, can see there being goals but a draw…2-2
Football Index – One to follow: Roberto Pereyra – top player, one to watch
Cardiff City 17:30 Manchester United
Cardiff City Stadium
TEAM NEWS: Alexis Sanchez is unavailable for Man United, but Scott McTominay, Chris Smalling and Luke Shaw could all feature.
Danny Ward remains sidelined for Cardiff, but full-backs Gregg Cunningham and Jazz Richards could return.
KEY FACT: United have lost their last three league away matches against promoted sides
MATCH ODDS: Cardiff 11/2 Draw 16/5 Man Utd 4/7
bet365 Pick: Sean Morrison anytime @10/1
ANDY SAYS: I think the change of manager inspires United and they take a good win…1-3
GRAEME SAYS: I am not sure how United respond, I can see Cardiff taking a point…1-1
Football Index – One to follow: Paul Pogba – can he recapture his form, still one of the most interesting investments around
