Tottenham have the chance to move into second place in the Premier League on Saturday.
With Liverpool and Manchester City not playing until later in the weekend, Spurs could climb into second with victory over Newcastle at Wembley.
Chelsea will move back into the top-four if they take anything from their home clash with bottom-of-the-table Huddersfield Town.
There is a huge capital derby clash at Selhurst Park as Crystal Palace host Fulham. The Cottagers, second from bottom, can move to within three points of The Eagles with victory.
There is another ‘six-pointer’ clash at Burnley with 16th plays 17th as Southampton provide the opposition.
Cardiff – third from bottom – are looking to avoid a third successive loss as they entertain Bournemouth in the Welsh capital.
Everton are hoping to move back into seventh, and they will leapfrog Wolves with victory over the Black Country giants at Goodison Park – but a draw would open the door for Watford to move above both of them as they travel to Brighton.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 12:30 Newcastle United
TEAM NEWS: Tottenham are still without star duo Dele Alli and Harry Kane. Heung-min Son should be available along with Ben Davies.
Newcastle are ready to hand a debut to record signing Miguel Almiron, whilst left-back Antonio Barreca – signed on loan from Monaco – could also feature. Jonjo Shelvey, Momo Diame and Paul Dummett could all be available.
KEY FACT: If Spurs win or lose here, they would set a new PL record for the most consecutive matches without a draw
MATCH ODDS: Spurs 4/9 Draw 7/2 Newcastle 8/1
bet365 Pick: Draw @7/2
ANDY SAYS: I have a feeling that Newcastle sneak a win here…0-2
GRAEME SAYS: Tough ask for Newcastle and Spurs win this…2-0
Football Index – One to follow: Harry Kane – he might be injured, but whilst he is not number on the Index, he provides value
Brighton & Hove Albion 15:00 Watford
TEAM NEWS: Alireza Jahanbakhsh and Bernardo are back in training and could be involved, meaning Jose Izquierdo
Kiko Femenia, Sebastian Prodl and Abdoulaye Doucoure remain sidelined for Watford but they hope to have Christian Kabasele, Troy Deeney and Roberto Pereyra available.
KEY FACT: Brighton have never lost a Premier League game in February
MATCH ODDS: Brighton 31/20 Draw 23/10 Watford 2/1
bet365 Pick: Draw @23/10
ANDY SAYS: A close call here, not sure I can split them so I will go draw…1-1
GRAEME SAYS: Watford are a strange team to call, but have to think they will have enough to win here…0-2
Football Index – One to follow: Roberto Pereyra – a fantastic player with so much to offer on the Index
Burnley 15:00 Southampton
TEAM NEWS: Peter Crouch could be in line to make his Premier League return and Burnley debut after his deadline day move. Robbie Brady and Johann Berg Gudmundsson could be in contention but Steven Defour and Matt Lowton are sidelined.
Southampton look set to welcome back Pierre-Emile Hojbjerg, but Ryan Bertrand, Mario Lemina and Michael Obafemi are all sidelined.
KEY FACT: Burnley are looking for their first ever win in February
MATCH ODDS: Burnley 31/20 Draw 5/2 Southampton 15/8
bet365 Pick: Draw @5/2
ANDY SAYS: Burnley are in good form and I believe they win this…2-0
GRAEME SAYS: Another close game at the bottom and I can see Southampton just having enough to get a draw…2-2
Football Index – One to follow: Mario Lemina – a superb player and worth keeping an eye on
Chelsea 15:00 Huddersfield Town
TEAM NEWS: Huddersfield could hand a debut to their new striker Karlan Grant, whilst Philip Billing returns to the squad.
Chelsea boss Maurizio Sarri has a near fully fit squad to choose from with Marco van Ginkel the only player not available to him.
KEY FACT: Chelsea are aiming to avoid a third consecutive league defeat, having last suffered a hat-trick of losses in November 2015
MATCH ODDS: Chelsea 1/5 Draw 13/2 Huddersfield 16/1
bet365 Pick: Under 2.5 goals @13/10
ANDY SAYS: Don’t see too many issues for Chelsea, home win coming…3-1
GRAEME SAYS: I don’t see how Huddersfield get anything from this, has to be a comfortable home win…3-0
Football Index – One to follow: Callum Hudson-Odoi – a fascinating young talent and well worth investing in
Crystal Palace 15:00 Fulham
TEAM NEWS: Wilfried Zaha is suspended for Palace, which could mean a debut for deadline day signing Michy Batshuayi. Cheikhou Kouyate and James Tomkins are both doubts.
Fulham are set to include deadline day signings Havard Nordtveit and Lazar Markovic, whilst Andre-Frank Anguissa could return. Joe Bryan remains a doubt and Alfie Mawson is sidelined.
KEY FACT: Fulham have lost only one of their last 11 league matches away to Palace
MATCH ODDS: Palace 21/20 Draw 5/2 Fulham 3/1
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: I am going with my former team here to take the win…2-0
GRAEME SAYS: I don’t think Fulham are great, have to go with Palace…3-0
Football Index – One to follow: Ryan Sessegnon – worth big investment
Everton 15:00 Wolverhampton Wanderers
TEAM NEWS: Wolves have a clean bill of health with Willy Boly now available after suspension.
Lucas Digne is suspended, whilst Phil Jagielka is sidelined – but Everton hope Idrissa Gueye and Yerry Mina are available.
KEY FACT: Wolves last win over Everton came in 1979
MATCH ODDS: Everton 13/10 Draw 12/5 Wolves 12/5
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: I think Wolves win this and just get the better of Everton…1-2
GRAEME SAYS: A fantastic looking game, and I see goals but also a draw…2-2
Football Index – One to follow: Ruben Neves – a wonderful talent and will only go one way on the Index
Cardiff City 17:30 AFC Bournemouth
Cardiff City Stadium
TEAM NEWS: Cardiff are set to hand a debut to new signing Leandro Bacuna and they could also welcome back Victor Camarasa and Josh Murphy. Harry Arter is unavailable as he can’t face his parent club.
Callum Wilson is sidelined until March, but new signing Dominic Solanke could be involved for the first time. Jefferson Lerma is struggling with an ankle problem.
KEY FACT: Bournemouth have lost their last six away matches
MATCH ODDS: Cardiff 9/4 Draw 5/2 Bournemouth 13/10
bet365 Pick: Cardiff to win @9/4
ANDY SAYS: Close call but I am just going for Cardiff to edge it…1-0
GRAEME SAYS: I think that Bournemouth might just edge this one…1-2
Football Index – One to follow: Dominic Solanke – could be a real one to watch