Liverpool will return to the top of the Premier League table on Saturday if they avoid defeat at home to Bournemouth.
The Reds, who lost top spot to Manchester City for the first time since December in midweek, only need a point to move back to the summit but Jurgen Klopp will be looking for all three points at Anfield.
The weekend’s action begins with Manchester United travelling to second from bottom Fulham, and Ole Gunnar Solskjaer’s men have the chance to move into the top-four with victory at Craven Cottage.
Arsenal, just a point worse off than United, will look to keep pace with them as they travel to bottom-of-the-table Huddersfield Town – who are in desperate need of a first victory under Jan Siewert.
Cardiff have the chance to move out of the relegation places for the first time this year as they travel to Southampton – who could find themselves in the bottom three if they lose. Cardiff will move above the Saints with the win.
Fourth from bottom Burnley travel to Brighton in the late kick-off and victory will see them move level on points with the Seagulls.
Crystal Palace are looking for back-to-back wins as they host West Ham at Selhurst Park, as Roy Hodgson’s men look to move further clear of the relegation battle.
The final game sees eighth place Watford host ninth placed Everton at Vicarage Road with Marco Silva and Richarlison looking for victory on their return to the club.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Fulham 12:30 Manchester United
TEAM NEWS: Manchester United have the luxury of a near fully fit with the only injury issue being Marcos Rojo – who is back in training.
Fulham are without Alfie Mawson, Marcus Bettinelli and Andre-Frank Anguissa, whilst new signings Lazar Markovic and Havard Nordtveit may have wait for their debuts, but they hope that Cyrus Christie and Andre Schurrle will be available.
KEY FACT: Fulham are aiming to win back-to-back Premier League home matches for the first time since April 2013
MATCH ODDS: Fulham 9/2 Draw 3/1 Man Utd 4/7
bet365 Pick: Both Teams To Score & over 2.5 goals @Evens
ANDY SAYS: Man Utd will continue their run of good form without too many issues…0-3
GRAEME SAYS: Fulham are not playing wonderful, and I see Man Utd winning comfortably…0-2
Football Index – One to follow: Marcus Rashford – huge potential in the England striker
Crystal Palace 15:00 West Ham United
TEAM NEWS: West Ham hope Marko Arnautovic and and Aaron Cresswell but The Hammers are still without a host of players with Samir Nasri, Jack Wilshere, Fabian Balbuena, Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini all ruled out.
Cheikhou Kouyate and Pape Souare both miss out for Crystal Palace.
KEY FACT: West Ham have won three of their last four away matches against Palace in all competitions
MATCH ODDS: Palace Evens Draw 23/10 West Ham 14/5
bet365 Pick: Draw @23/10
ANDY SAYS: Tough call here, and should be a good derby clash but have to go with a draw…1-1
GRAEME SAYS: I can see Palace snatching the win here…2-1
Football Index – One to follow: Wilfried Zaha – could be set for big summer move, so well worth looking at
Huddersfield Town 15:00 Arsenal
John Smith’s Stadium
TEAM NEWS: Arsenal are waiting on Pierre-Emerick Aubameyang, Granit Xhaka, Ainsley Maitland-Niles and Shkodran Mustafi but hope they will all be fit but they are without Sokratis Papastathopoulos, Rob Holding, Hector Bellerin and Danny Welbeck.
Huddersfield’s Chris Lowe is a doubt due to illness whist Jonathan Hogg and Erik Durm could feature, but Isaac Mbenza is ruled out along with Danny Williams and Adbelhamid Sabiri.
KEY FACT: Huddersfield are looking for their first victory in 12 competitive matches against Arsenal
MATCH ODDS: Huddersfield 4/1 Draw 3/1 Arsenal 8/13
bet365 Pick: Arsenal -1 @8/5
ANDY SAYS: Huddersfield are not playing great, and Arsenal will win here…0-2
GRAEME SAYS: Town need a win for sure, but I don’t see it coming against Arsenal…1-3
Football Index – One to follow: Pierre-Emerick Aubameyang – not many better than the Gabonese star at the moment
Liverpool 15:00 AFC Bournemouth
TEAM NEWS: Bournemouth are without star forward David Brooks and Callum Wilson, along with Lewis Cook and Simon Francis.
Captain Jordan Henderson has been ruled out along with Dutch midfielder Gino Wijnaldum. They add to Liverpool’s lengthy injury list which already includes Dejan Lovren, Trent Alexander-Arnold, Joe Gomez and Alex Oxlade-Chamberlain.
KEY FACT: Bournemouth are looking for their second victory over Liverpool in all competitions, at the 15th attempt
MATCH ODDS: Liverpool 1/5 Draw 6/1 Bournemouth 11/1
bet365 Pick: Liverpool & Under 3.5 goals @13/10
ANDY SAYS: Liverpool will get the three points and go back to the top of the table…3-1
GRAEME SAYS: Bournemouth have too many good players missing, easy home win…4-0
Football Index – One to follow: David Brooks – might be injured but this boy is going to be a star
Southampton 15:00 Cardiff City
TEAM NEWS: Danny Ings, Mario Lemina and Michael Obafemi are all sidelined for Southampton, but Pierre-Emile Hojbjerg could be available after concussion.
Victor Camarasa is a major doubt for Cardiff, who are without Sean Morrison who is out with an Appendicitis.
KEY FACT: Cardiff have the chance to secure a second consecutive top-flight victory for the first time since April 1962
MATCH ODDS: Southampton 8/11 Draw 13/5 Cardiff 15/4
bet365 Pick: Cardiff highest scoring half – 2nd @2/1
ANDY SAYS: A real six-pointer and I am just going with Southampton to edge it…2-1
GRAEME SAYS: I could see this being a tight affair and not many goals, so goalless draw…0-0
Football Index – One to follow: Nathan Redmond – could still represent something of a bargain on the Index
Watford 15:00 Everton
TEAM NEWS: Leighton Baines is sidelined for Everton, but Yerry Mina and Phil Jagielka could be available.
Kiko Femenia, Sebastian Prodl and Abdoulaye Doucoure remain sidelined for Watford but they hope Roberto Pereyra and Isaac Success could be available.
KEY FACT: Everton are looking to win a second consecutive PL away fixture for the first time since September 2016
MATCH ODDS: Watford 5/4 Draw 23/10 Everton 11/5
bet365 Pick: Over 2.5 goals @10/11
ANDY SAYS: I think Watford are looking good again and will have too much for Everton…2-1
GRAEME SAYS: Has to be a Watford win for me, Everton are out of sorts..2-0
Football Index – One to follow: Richarlison – a wonderful talent, could haunt his former club in this one
Brighton & Hove Albion 17:30 Burnley
TEAM NEWS: Dale Stephens should be fit for Brighton, meaning Jose Izquierdo is the only player sidelined for the home side.
Aaron Lennon is ruled out for Burnley, who hope to have Matt Lowton and Steven Defour available.
KEY FACT: Burnley are unbeaten in their last six league matches against Brighton
MATCH ODDS: Brighton Evens Draw 23/10 Burnley 11/4
bet365 Pick: Draw @23/10
ANDY SAYS: Another tight game but I will go with home advantage and Brighton…2-1
GRAEME SAYS: Brighton could be sucked into trouble with defeat here and I think Burnley might edge it…1-2
Football Index – One to follow: Peter Crouch – could the former England man give you a profit? Maybe…