Manchester City and Manchester United can’t be separated and the two of them are both in action on a bumper Saturday of action in the Premier League.

City host winless and goalless Crystal Palace at The Etihad as Roy Hodgson looks for his first win in charge of The Eagles.

United face a trip to the South Coast to take on Southampton.

Champions Chelsea will look to maintain touching distance of the top-two as they face the always tricky trip to Stoke City.

The early kick-off is a capital derby as West Ham United welcome rivals Tottenham Hotspur to the London Stadium.

Burnley and Huddersfield both have the chance to move into the top-five with victory as they face each other at Turf Moor.

Everton and Bournemouth – both looked languishing in the bottom-three – lock horns at Goodison Park.

Watford suffered their first loss against Man City last week and they will be looking to respond at Swansea.

The final game of the day sees Leicester looking to emulate their midweek League Cup triumph over Liverpool.

See below for a run-down on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent Barry Silkman and our own Football Insider Graeme Bailey  together with everything you need to know from the bookies – with Ladbrokes’s Alex Apati.

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West Ham 12:30 Spurs
London Stadium

TEAM NEWS: West Ham United will be without Pedro Obiang and Jams Collins, but Manuel Lanzini could figure after returning to training. Spurs have no new injuries but Victor Wanyama, Erik Lamela and Danny Rose are all out.
KEY FACT: Spurs are looking to win their opening three away matches of a PL season for the first time
MATCH ODDS: West Ham 9/2 Draw 3/1 Spurs 6/10
ANDY SAYS: I can see Tottenham winning this, but it will be close…1-2 
GRAEME SAYS: Spurs should win this, I think they will – West Ham are poor at the moment…0-2 
SILKY SAYS: I think West Ham can get something here and will take a point…1-1
LADBROKES PICK:  West Ham not to lose – 13/10
FOOTBALLIndex – One to follow: Harry Kane under £5 – get on it!

Burnley 15:00 Huddersfield
Turf Moor

TEAM NEWS: Goalkeeper Tom Heaton is a long-term absentee for Burnley whilst former Town striker Nahki Wells is sidelined with an ankle problem. Midfielder Danny Williams is a major doubt, but Jonathan Hogg and Steve Mounie could both feature.
KEY FACT: This will be the first top-flight meeting between these clubs since 1971.
MATCH ODDS: Burnley 11/10 Draw 21/10 Huddersfield 27/10
ANDY SAYS: I think Huddersfield could cause a bit of a shock here and claim the win…0-1
GRAEME SAYS: Burnley for me in this one, they are very good at Turf Moor…2-0
SILKY SAYS: Tough call so am going to have to say a draw, can’t split them…1-1
LADBROKES PICK:  Burnley to beat Huddersfield – 11/10
FOOTBALLIndex – One to follow: No players, but Steve Mounie is not too far off being added in the squad list

Everton 15:00 Bournemouth
Goodison Park

TEAM NEWS: Everton have no new injuries but Ramiro Funes Mori, James McCarthy, Seamus Coleman, Yannick Bolasie and Ross Barkley remain sidelined. Junior Stanislas and Steve Cook are available again but Callum Wilson remains short of fitness.
KEY FACT: Everton are aiming to avoid losing four PL matches in a row for the first time since January 2015
MATCH ODDS: Everton 8/13 Draw 14/5 Bournemouth 17/4
ANDY SAYS: Another away win for me in this one, not been impressed by Everton at all…1-2
GRAEME SAYS: I don’t see how Everton don’t win his really, but they have to improve…2-0
SILKY SAYS: A tough call but I just give Everton the edge and should win…2-1
LADBROKES PICK:  Everton to beat Bournemouth & BTTS – 5/2
FOOTBALLIndex – One to follow: Tom Davies at 88p, looks a very good prospect

Man City 15:00 Crystal Palace
Etihad Stadium

TEAM NEWS: Ilkay Gundogan limped off in midweek on his return from injury and is unlikely to be involved whilst Vincent Kompany will be assessed. Mamadou Sakho and Pape Souare made their long awaited returns from injury in midweek and will be involved.
KEY FACT: Palace are aiming to avoid joining Portsmouth as the only team to lose their first six matches of a PL season.
MATCH ODDS: Man City 2/15 Draw 15/2 Palace 22/1
ANDY SAYS: I don’t see how Palace get anything from this game, home win…3-0
GRAEME SAYS: Comfortable home win, not problems for City here…4-0
SILKY SAYS: City are too good for most teams and will be for Palace…5-1
LADBROKES PICK:  Man City -5 – 12/1
FOOTBALLIndex – One to follow: Sergio Aguero at just £3.15 – bargain

Southampton 15:00 Man Utd
St. Mary’s Stadium

TEAM NEWS: Paul Pogba and Axel Tuanzebe are sidelined, with Marcos Rojo and Zlatan Ibrahimovic still ruled out for a number of months. Virgil van Dijk could be handed his first start of the season, following his transfer stand-off with the club.
KEY FACT: Romelu Lukaku needs one goal to equal Louis Saha’s record for most goals scored after six PL appearances for United
MATCH ODDS: Southampton 18/5 Draw 5/2 Man Utd 4/5
ANDY SAYS: United have been playing really well and don’t see their run coming to an end here…0-2
GRAEME SAYS: I think Southampton could put up a good fight, but United win for sure…1-3
SILKY SAYS: A close one, but I don’t see how United won’t win…1-2
LADBROKES PICK:  Marcus Rashford to score and Man United to win – 16/5
FOOTBALLIndex – One to follow: Marcus Rashford is on the up, get involved!

Stoke 15:00 Chelsea
bet365 Stadium

TEAM NEWS: Eden Hazard should start his first league game of the season and Pedro is also ready to play but Danny Drinkwater is still not fit to make his debut. David Luiz is also out due to suspension, he also has a suspected broken wrist. Kurt Zouma is ineligible to face his parent club. Geoff Cameron is sidelined with a hamstring injury, whilst Ryan Shawcross is also a doubt with a back problem.
KEY FACT: Chelsea have won seven of their last eight Premier League away matches
MATCH ODDS: Stoke 19/4 Draw 29/10 Chelsea 6/10
ANDY SAYS: This is not an easy trip for Chelsea, and I think Stoke might just get a draw out of this…1-1
GRAEME SAYS: Always a tough game, but Atonio Conte knows what he is doing…1-2
SILKY SAYS: I think Chelsea will be far too good for Stoke, who haven’t been playing well for me…0-3
LADBROKES PICK:  Michy Batshuayi to score at any time v Stoke – 13/10
FOOTBALLIndex – One to follow: Eden Hazard is back to fitness and at just over £4 – a great buy for any portfolio

Swansea 15:00 Watford
Liberty Stadium

TEAM NEWS: Wilfried Bony is in line to make his first Premier League start of the season. Leon Britton could feature but Nathan Dyer, Ki Sung-yueng and Kyle Bartley. Miguel Britos remains suspended and Craig Cathcart, Tommie Hoban and Younes Kaboul are sidelined. Sebastian Prodl and Kiko Femenia could return.
KEY FACT: Swansea City have lost only one of their last 10 home league meetings with Watford
MATCH ODDS: Swansea 27/20 Draw 11/5 Watford 21/10
ANDY SAYS: Should be an interesting game with goals, can’t split them so draw…2-2
GRAEME SAYS: It depends how Watford react to their Man City thrashing, away win…1-2
SILKY SAYS: Yeah tough one to call, Swansea haven’t been great but will back them to get a point…2-2
LADBROKES PICK: Swansea v Watford – BTTS – 5/6
FOOTBALLIndex – One to follow: Andre Gray still looks a fascinating prospect at just 66p

Leicester 17:30 Liverpool
King Power Stadium

TEAM NEWS: Matt James remains sidelined, but Jamie Vardy and Christian Fuchs are in line to start. Emre Can, Joel Matip and Dejan Lovren are all major doubts for Liverpool and will undergo checks before the game.
KEY FACT: Leicester have won two of their last three PL meetings with Liverpool
MATCH ODDS: Leicester 29/10 Draw 27/10 Liverpool 20/23
ANDY SAYS: I think Liverpool will bounce back from the midweek defeat to take a comfortable win…0-2
GRAEME SAYS: I think Leicester will get something here, perhaps not a win but a draw…2-2
SILKY SAYS: Tough one, but I think Liverpool’s class will tell and they will get the three points…1-2
LADBROKES PICK:  Leicester to beat Liverpool – 29/10
FOOTBALLIndex – One to follow: Harry Maguire has done well since arriving at Leicester, long-term great prospect at 66p