Manchester City have the chance to return to the top of the Premier League table on Saturday.
Champions City are just a point adrift of title rivals Liverpool, who are not in action until Sunday – so if they avoid loss at Bournemouth they will return to the summit, although Pep Guardiola will be looking for all three points on the South Coast.
This time last week, Tottenham had the chance to move to within two points of the top of the table – but they have suffered back to back losses, but will be desperate to avoid a third as they host arch rivals Arsenal at Wembley – who in stark contrast have won their last three.
If Arsenal fail to win, then that will allow Manchester United to reclaim four spot as they host Southampton – who jumped out of the bottom three in midweek.
Southampton’s win sent Cardiff back into the drop zone – but the Bluebirds could climb up to 16th, as Brighton could also find themselves in the relegation places if Cardiff can beat Wolves at Molineux.
Albion host bottom-of-the-table Huddersfield, who recorded their first win of 2019 in midweek as they defeated Wolves.
Crystal Palace and Burnley have both moved away from the danger zone in recent weeks, and they will both be hoping to increase the current five-point gap between them and the bottom three as they clash at Turf Moor.
Finally, West Ham could move up to ninth in the table if they beat Newcastle at The London Stadium.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 12:30 Arsenal
TEAM NEWS: Tottenham hope to have Eric Dier and Jan Vertonghen available, but Dele Alli is unlikely to be back.
Arsenal could have Laurent Koscielny available for the game, but Hector Bellerin, Rob Holding and Danny Welbeck remain sidelined.
KEY FACT: Only once in their top-flight history have Spurs won three consecutive home matches against the Gunners – the last time being from 1960 to 1961
MATCH ODDS: Tottenham Evens Draw 13/5 Arsenal 5/2
bet365 Pick: Both Teams Not To Score @5/4
ANDY SAYS: Tough call here, as much as I would like a Spurs win, I see this being a draw…1-1
GRAEME SAYS: I can see Spurs bouncing back with a win, but this will be a close one…3-2
Football Index – One to follow: Christian Eriksen – Due for an upturn in form, worth bearing in mind
AFC Bournemouth 15:00 Manchester City
TEAM NEWS: Jefferson Lerma is suspended for Bournemouth, who are without Steve Cook, Simon Francis, Lewis Cook and Callum Wilson, but they hope to have Dominic Solanke and Junior Stanislas available.
City hope to have John Stones and Gabriel Jesus available, but Fernandinho, Fabian Delph, Aymeric Laporte and Claudio Bravo are ruled out.
KEY FACT: Bournemouth’s only win in eight competitive fixtures against Arsenal came at the Vitality Stadium last season
MATCH ODDS: Bournemouth 11/1 Draw 11/2 Man City 1/5
bet365 Pick: Both Teams To Score @4/5
ANDY SAYS: Comfortable City win coming up…0-4
GRAEME SAYS: Have to go with City, but won’t be an easy three points…0-2
Football Index – One to follow: Raheem Sterling – One of the form players in world football at the minute
Brighton & Hove Albion 15:00 Huddersfield Town
TEAM NEWS: Brighton come into the game without Leon Balogun and Pascal Gross.
Huddersfield are without Danny Williams, Isaac Mbenza and Adama Diakhaby are sidelined but Demeaco Duhaney could be available.
KEY FACT: Brighton are looking to avoid recording consecutive home defeats in the Premier League for the first time
MATCH ODDS: Brighton 4/5 Draw 12/5 Huddersfield 15/4
bet365 Pick: Brighton to win @4/5
ANDY SAYS: Close game but have to go for Brighton to edge this…1-0
GRAEME SAYS: Can Huddersfield win two-in-a-row, can’t see it – home win coming…2-0
Football Index – One to follow: Solly March – A top young English, well worth following
Burnley 15:00 Crystal Palace
TEAM NEWS: Ashley Westwood is a doubt with illness for Burnley, who are without Steven Defour and Aaron Lennon.
Mamadou Sakho and Pape Souare are sidelined, but they could welcome back Aaron Wan-Bissaka
KEY FACT: Burnley’s last 49 Premier League goals have all been scored inside the box
MATCH ODDS: Burnley 9/5 Draw 9/4 Palace 6/4
bet365 Pick: Under 2.5 goals @8/11
ANDY SAYS: I think Palace get something here, but only a draw as it will be a close game…1-1
GRAEME SAYS: Burnley are in-form and they should see off Palace…2-0
Football Index – One to follow: Aaron Wan-Bissaka – In line for summer move, so one to keep track of
Manchester United 15:00 Southampton
TEAM NEWS: Ander Herrera, Jesse Lingard and Juan Mata added to United’s lengthy injury list last week which already includes Nemanja Matic and Antonio Valencia. They hope that Phil Jones, Anthony Martial and Matteo Darmian could be available.
Southampton remain without Michael Obafemi, Danny Ings and Mario Lemina.
KEY FACT: Southampton have drawn their last two league matches against Man Utd
MATCH ODDS: Man Utd 4/9 Draw 10/3 Southampton 13/2
bet365 Pick: Arsenal win & Under 3.5 goals @6/4
ANDY SAYS: United won’t have too many issue here and will win…3-1
GRAEME SAYS: Man Utd will win here, no problems – convincing win coming…4-0
Football Index – One to follow: Anthony Martial – A lot of value left in the French starlet
Wolverhampton Wanderers 15:00 Cardiff City
TEAM NEWS: Wolves have the luxury of a fully fit squad to choose from.
Cardiff are without Joe Ralls, but expect to welcome back Victor Camarasa.
KEY FACT: Wolves have lost five of their last seven league matches against the Bluebirds
MATCH ODDS: Wolves 4/9 Draw 7/2 Cardiff 11/2
bet365 Pick: Wolves win & Under 2.5 goals @9/4
ANDY SAYS: Big ask for Cardiff to get anything and has to be a Wolves win for me…2-0
GRAEME SAYS: Wolves will bounce back to form with a win here…2-0
Football Index – One to follow: Raul Jimenez – On-loan Wolves star has real potential
West Ham United 17:30 Newcastle United
TEAM NEWS: Marko Arnautovic and Fabian Balbuena could be back for West Ham, but they will be without Aaron Cresswell, Arthur Masuaku, Jack Wilshere, Andriy Yarmolenko, Carlos Sanchez and Winston Reid.
Newcastle are approaching a fully fit squad with only Ciaran Clark and Rob Elliot missing.
KEY FACT: No side have lost more Premier League away matches in London than Newcastle
MATCH ODDS: West Ham 11/10 Draw 12/5 Newcastle 12/5
bet365 Pick: Draw or Newcastle @5/6
ANDY SAYS: I can see Newcastle winning here, West Ham are very inconsistent…1-2
GRAEME SAYS: I can see Newcastle getting something here, at least a draw – but maybe sneaking a win…0-1
Football Index – One to follow: Miguel Almiron – One to watch, invest in him now