Manchester City could go four points clear at the top of the Premier League table on Saturday.
Champions City host eighth place Watford, who could move up one place if they avoid defeat.
Third placed Tottenham are looking for their first league win in nearly a month as they travel to fourth from bottom Southampton. Defeat for Spurs could see them drop to fourth over the weekend – which would be the first time they have not been in the top-three since early December.
Cardiff have the chance to move out of the bottom-three if they beat West Ham in South Wales.
Second from bottom Fulham are looking to avoid a sixth straight defeat as they travel to the King Power as Brendan Rodgers takes charge of his first home with Leicester.
Bottom of the table Huddersfield still hold a slim hope of staying up as they host Bournemouth at the John Smith’s Stadium looking for successive home wins. The Cherries are without a league win since January.
The opening game of the weekend sees rivals Crystal Palace and Brighton clash at Selhurst Park, in what promises to be a eagerly fought contest.
Finally, Newcastle are looking to return to winning ways as they host Everton at St James’ Park.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Crystal Palace 12:30 Brighton & Hove Albion
Selhurst Park
TEAM NEWS: Pape Souare and Mamadou Sakho are both sidelined for Crystal Palace.
Leon Balogun remains out injured for Brighton, who are also set to be without Pascal Gross.
KEY FACT: Crystal Palace have lost just one of their last nine home meetings with Brighton
MATCH ODDS: Palace 4/5 Draw 5/2 Brighton 7/2
bet365 Pick: Wilfried Zaha to score anytime @15/8
ANDY SAYS: What do you expect me to say for this one – Palace all the way…3-1
GRAEME SAYS: Cracking start to the weekend and I have to go with Palace…2-0
Football Index – One to follow: Solly March – Wonderful English talent to keep an eye on
Cardiff City 15:00 West Ham United
Cardiff City Stadium
TEAM NEWS: The only player missing for Cardiff is defender Sol Bamba, who has been ruled out for the rest of the season.
West Ham welcome back Aaron Cresswell and Fabian Balbuena, but remain without Jack Wilshere, Winston Reid, Carlos Sanchez and Andriy Yarmolenko.
KEY FACT: Manuel Pellegrini’s first ever PL defeat was away at Cardiff in August 2013
MATCH ODDS: Cardiff 12/5 Draw 23/10 West Ham 11/10
bet365 Pick: Cardiff to score in second half @5/6
ANDY SAYS: I think West Ham will come out on top here, and score a few in the process…1-3
GRAEME SAYS: I don’t see a lot of goals here, has to be a draw for me…1-1
Football Index – One to follow: Manuel Lanzini – Has returned to action and should be followed
Huddersfield Town 15:00 AFC Bournemouth
John Smith’s Stadium
TEAM NEWS: Junior Stanislas and Callum Wilson could be back for Bournemouth, but they are still without Dominic Solanke, Steve Cook, Simon Francis and Lewis Cook.
Huddersfield are without injured trio Adama Diakhaby, Isaac Mbenza and Demeaco Duhaney, and the suspended Tommy Smith. They are hoping Jonathan Hogg and Laurent Depoitre could feature.
KEY FACT: All three Premier League meetings between these teams have been won by the home side
MATCH ODDS: Huddersfield 12/5 Draw 11/5 Bournemouth 6/5
bet365 Pick: Draw @11/5
ANDY SAYS: Close game but I think that Huddersfield can win this…1-0
GRAEME SAYS: I see Bournemouth snatching an away win here, but won’t be a classic…1-2
Football Index – One to follow: David Brookes – A fantastic talent and very good value on the Index
Leicester City 15:00 Fulham
King Power Stadium
TEAM NEWS: Marc Albrighton and Daniel Amartey remain sidelined, but they hope Jamie Vardy will be fit.
Fulham are without Andre Schurrle, Alfie Mawson and Marcus Bettinelli.
KEY FACT: Leicester are looking to win consecutive home league matches within the same season for the first time since January 2018
MATCH ODDS: Leicester 4/7 Draw 16/5 Fulham 9/2
bet365 Pick: Both Teams To Score @3/4
ANDY SAYS: Don’t see Leicester having a major issue here, home win…2-0
GRAEME SAYS: Fulham will need to park the bus to get something, they won’t and they won’t get anything…3-1
Football Index – One to follow: James Maddison – Will soon be an England international, one to keep an eye on
Newcastle United 15:00 Everton
St James’ Park
TEAM NEWS: Sean Longstaff has joined Ciaran Clark and Rob Elliott on the sidelines for Newcastle.
Everton’s only injury concern is Leighton Baines, who is set to miss out.
KEY FACT: Everton have lost just one of their last 12 Premier League meetings with Newcastle
MATCH ODDS: Newcastle 17/10 Draw 11/5 Everton 13/8
bet365 Pick: Everton to win @13/8
ANDY SAYS: I think Everton will get something here, but not sure they are going to win…1-1
GRAEME SAYS: Everton have not been overly impressive so I think Newcastle can take the three points…2-1
Football Index – One to follow: Richarlison – Such a good player, could go to the very top
Southampton 15:00 Tottenham Hotspur
St Mary’s
TEAM NEWS: Southampton remain without Michael Obafemi, Danny Ings and Mario Lemina.
Tottenham hope to have Dele Alli and Harry Winks available, but Kieran Trippier is set to be sidelined.
KEY FACT: Southampton are aiming for their first PL home win over Spurs since 2012
MATCH ODDS: Southampton 3/1 Draw 13/5 Spurs 17/20
bet365 Pick: Southampton to score first @8/5
ANDY SAYS: Tough game for Spurs, but I see them coming through with the win they need…1-2
GRAEME SAYS: Tottenham are a class act and that will come through here with all three points…1-3
Football Index – One to follow: Christian Eriksen – Due for an upturn in form, worth bearing in mind
Manchester City 17:30 Watford
Etihad Stadium
TEAM NEWS: Watford could have a fully fit squad to choose from with the only doubt being Kiko Femenia.
City have a number of big names missing with Kevin De Bruyne, Fernandinho, John Stones and Aymeric Laporte all sidelined, but Fabian Delph could return.
KEY FACT: Man City have never lost a PL match against Watford
MATCH ODDS: Man City 1/7 Draw 13/2 Watford 16/1
bet365 Pick: Under 3.5 goals @Evens
ANDY SAYS: City are in good form at the moment, and that won’t stop here…4-0
GRAEME SAYS: Watford are an excellent side and they could very well come away with a shock point…2-2
Football Index – One to follow: Bernardo Silva – Has been superb this season, he still has real potential on the Index
