Tottenham Hotspur and Manchester United are the only top-six clubs in action on Saturday as they look to boost their top-four hopes.
Spurs could move into third in the table with all three points as they face already relegated Huddersfield in the day’s opening game at their new White Hart Lane home.
Defeat for Tottenham would allow United the chance to catch them, but victory at least would take them above Arsenal into fifth as they face West Ham at Old Trafford.
Third-from-bottom Cardiff are approaching must-win status in all their games, and their trip to Burnley certainly is that as Neil Warnock’s men could move to within a point of safety with victory.
Should Cardiff win, then it would be Southampton who would be looking over their shoulders nervously and they will be hoping to look after themselves as they host Wolves at St Mary’s. Wolves in eighth could finish the weekend in tenth if they lose, so they will be looking for maximum points on the South Coast.
Everton could move into seventh with victory and they will be looking for all three points at relegated Fulham.
The final game of the day is a South Coast derby as Brighton welcome Southampton to the AMEX.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 12:30 Huddersfield Town
Tottenham Hotspur Stadium
TEAM NEWS: Tottenham are without captain Harry Kane, who joins Serge Aurier, Eric Dier and Erik Lamela but they hope that Dele Alli will be fit for the clash.
Isaac Mbenza remains a doubt for Huddersfield, who are without Demeaco Duhaney and Laurent Depoitre.
KEY FACT: Huddersfield have not beaten Tottenham since 1956
MATCH ODDS: Tottenham 1/5 Draw 6/1 Huddersfield 10/1
bet365 Pick: Spurs to win to nil @20/21
ANDY SAYS: Spurs will have far too much for Huddersfield…3-0
GRAEME SAYS: Could very well be a cricket score and the biggest the new stadium has seen…6-0
Football Index – One to follow: Son Heung-min – What a player, his stock will rise from here, little doubt
Brighton & Hove Albion 15:00 AFC Bournemouth
TEAM NEWS: Brighton are hopeful that Pascal Gross and Solly March will both be available, which will mean a fully fit squad for Chris Hughton.
Bournemouth are without a number of long-term injury victims including Lewis Cook, Simon Francis, Steve Cook, Andrew Surman and Charlie Daniels.
KEY FACT: Brighton have lost only one of their last 14 home matches against Bournemouth
MATCH ODDS: Brighton 5/4 Draw 11/5 Bournemouth 9/4
bet365 Pick: Under 2.5 goals @4/5
ANDY SAYS: Close game but I think Bournemouth will get something…1-1
GRAEME SAYS: I can see Brighton claiming in this, Bournemouth are not in great form…2-0
Football Index – One to follow: Solly March – An outstanding young talent, one to watch
Burnley 15:00 Cardiff City
TEAM NEWS: Phil Bardsley is a doubt for Burnley, who are already without Peter Ccrouch, Steven Defour and Aaron Lennon.
Cardiff hope to have Jazz Richards and Harry Arter available, but Callum Paterson, Matthew Connolly and Sol Bamba are sidelined.
KEY FACT: Sean Dyche has never lost against Neil Warnock
MATCH ODDS: Burnley 5/6 Draw 5/2 Cardiff 10/3
bet365 Pick: Draw @5/2
ANDY SAYS: I think that Cardiff could get something here, draw for me…1-1
GRAEME SAYS: Cardiff need the win, and they might just squeeze it out here…0-1
Football Index – One to follow: Dwight McNeil – Burnley’s young midfielder is a big talent and well worth looking at
Fulham 15:00 Everton
TEAM NEWS: Floyd Ayite could return for Fulham, but Alfie Mawson and Lazar Markovic remain sidelined.
Michael Keane and Morgan Schneiderlin should be available but Yerry Mina remains sidelined.
KEY FACT:Everton have lost only one of their last 19 away matches against newly promoted teams
MATCH ODDS: Fulham 15/4 Draw 13/5 Everton 3/4
bet365 Pick: Everton to win & Over 2.5 goals @6/4
ANDY SAYS: Everton will be far too good for Fulham here, no doubt…1-3
GRAEME SAYS: Hard to see how Fulham will get anything here, has to be an Everton win…0-2
Football Index – One to follow: Richarlison – Brazilian ace has had a good season, and has real potential to rise on the Index
Southampton 15:00 Wolverhampton Wanderers
TEAM NEWS: Wolves have the luxury of a full fit squad to choose from.
Southampton welcome back Danny Ings after he was ruled out of their last match with Liverpool due to the fact he could not face his parent club. Mario Lemina and Michael Obafemi are ruled out through injury.
KEY FACT: Wolves haven’t kept a clean sheet in any of their last 12 Premier League away matches
MATCH ODDS: Southampton 6/4 Draw 21/10 Wolves 19/10
bet365 Pick: Draw @21/10
ANDY SAYS: This could be a good game and I think Southampton will get a result…2-2
GRAEME SAYS: Wolves look to bounce back from FA Cup heartbreak and I think they will with a win…1-3
Football Index – One to follow: Ruben Neves – An outstanding talent, and one who could be on the end of a big move this summer
Manchester United 17:30 West Ham United
TEAM NEWS: Samir Nasri is a doubt for West Ham, who are without Andy Carroll, Jack Wilshere, Winston Reid, Andriy Yarmolenko and Carlos Sanchez.
United could welcome back Nemanja Matic, Ander Herrera and Alexis Sanchez, but Matteo Darmian, Eric Bailly and Antonio Valencia remain sidelined.
KEY FACT: Man Utd are winless in their last four Premier League matches immediately following a European fixture
MATCH ODDS: Man Utd 4/11 Draw 4/1 West Ham 13/2
bet365 Pick: Under 2.5 goals @6/4
ANDY SAYS: Home win coming here, I think United get the job done…2-0
GRAEME SAYS: Man Utd need the three points here, and I think they just about get it…2-1
Football Index – One to follow: Marcus Rashford – Has all the ability in the world…plenty of value