Champions-elect Liverpool will look to take another step to sealing their first ever Premier League crown as they visit Watford on Saturday.
The day’s final game sees Liverpool travel to Vicarage Road with their unbeaten record intact and they will be more than hopeful of maintaining that against the second-from-bottom Hornets.
With Manchester City not in league action this weekend due to the Carabao Cup Final, a Liverpool win will also see them move 25 points clear.
Chelsea’s battle for a top-four finish continues on the South Coast at Bournemouth – who are in desperate need of a win themselves, sitting just two points ahead of the relegation places.
Saturday’s opening game is a huge one as Brighton meet arch-rivals Crystal Palace at the AMEX Stadium. Brighton come into the game just four points above the drop-zone.
Relegation threatened West Ham are desperate for three points to lift them out of the bottom three, which will happen if they beat Southampton at the London Stadium.
Burnley and Newcastle clash at St James’ Park, but neither have relegation worries – indeed The Clarets sit in tenth place coming into the clash.
We run through every game including predictions from our own Football Insider Graeme Bailey and Bet365’s Steve Freeth.
Brighton & Hove Albion 12:30 Crystal Palace
TEAM NEWS: Jose Izquierdo is the only player missing for Brighton as they have Dale Stephens ready to return. | Cheikhou Kouyate and Luka Milivojevic should be available for Palace but James Tomkins, Mamadou Sakho and Jeffrey Schlupp are sidelined.
KEY FACT: Brighton are unbeaten in their last three league meetings with Crystal Palace
MATCH ODDS: Brighton 21/20 Draw 9/4 Palace 29/10
bet365 Pick: Over 2.5 goals @13/10
GRAEME SAYS: I think Brighton get the better of the big rivals here and could be a good win…2-0
Football Index – One to follow: Neil Maupay – proving himself as a real Premier League performer
AFC Bournemouth 15:00 Chelsea
TEAM NEWS: Nathan Ake will be available for Bournemouth, but they are still without Jefferson Lerma,
Arnaut Danjuma Groeneveld, Lloyd Kelly, Charlie Daniels, David Brooks and Chris Mepham. | Callum Hudson-Odoi and Tammy Abraham remain doubtful for Chelsea, who will be missing N’Golo Kante, Christian Pulisic and Marco van Ginkel.
KEY FACT: None of the nine previous Premier League meetings between these sides have been drawn
MATCH ODDS: Bournemouth 15/4 Draw 14/5 Chelsea 8/11
bet365 Pick: Both Teams Not To Score @19/20
GRAEME SAYS: Chelsea need to bounce back from their hammering at the hands of Bayern Munich and I think they do it here to continue Bournemouth’s poor run of form…1-3
Football Index – One to follow: Reece James – developing into a brilliant young attacking full-back and one who could challenge Trent Alexander-Arnold in years to come
Newcastle United 15:00 Burnley
St. James’ Park
TEAM NEWS: Chris Wood and Johann Berg Gudmondsson could feature for Burnley, but Matt Lowton, Ashley Barnes and Ben Gibson are absent. | Javi Manquillo, Christian Atsu and Jonjo Shelvey could feature for Newcastle but they are without a host of players including Emil Krafth, Ciaran Clark, Jack Colback, Paul Dummett, Andy Carroll, Jetro Willems and the suspended Valentino Lazaro.
KEY FACT: Newcastle have not lost a home league match against Burnley since April 1976
MATCH ODDS: Newcastle 13/8 Draw 21/10 Burnley 19/10
bet365 Pick: Burnley Draw No Bet @Evens
GRAEME SAYS: This will not be a good game, I think they will both be happy with a draw and that is what they will get…0-0
Football Index – One to follow: Josh Brownhill – has the potential to be a very good Premier League player
West Ham United 15:00 Southampton
TEAM NEWS: West Ham are without Andriy Yarmolenko, Ryan Ferdericks, Jack Wilshere and Tomas Soucek. | Southampton hope to have Moussa Djenepo and Kyle Walker-Peters available, meaning the only player they have missing is Nathan Redmond.
KEY FACT: West Ham will move out of the bottom three with victory
MATCH ODDS: West Ham 33/20 Draw 13/5 Southampton 6/4
bet365 Pick: Stuart Armstrong to score anytime @4/1
GRAEME SAYS: West Ham really need a win here, will they get it? Not so sure I think Southampton’s good form will continue…1-2
Football Index – One to follow: James Ward-Prowse – Often over-looked but is a very good English midfielder
Watford 17:30 Liverpool
TEAM NEWS: Liverpool captain Jordan Henderson is unlikely to make the game and will join James Milner, Nathaniel Clyne and Xherdan Shaqiri on the sildeines. | Watford could have a near fully fit squad with only Daryl Janmaat missing with Kiko Femenia set to return.
KEY FACT: Liverpool have won all 13 of their matches at Anfield this season
MATCH ODDS: Watford 7/1 Draw 15/4 Liverpool 2/5
bet365 Pick: Both Teams To Score @4/5
GRAEME SAYS: Watford need the points here, but they won’t get it as Liverpool win again…0-2
Football Index – One to follow: Jordan Henderson – Not many have been better than the Liverpool skipper this season