Manchester City can close the gap on leaders Liverpool on Saturday.
The champions begin the day in the early kick-off as they host Aston Villa, and victory would put them to within three points of Liverpool – who are not playing until Sunday.
In-form Chelsea are coming off the back of a brilliantly win at Ajax in midweek and they looking for a fourth successive league win, as they travel to Burnley in the day’s late kick-off.
Bottom-of-the-table Watford remain winless and they will be hoping to break that duck as they welcome Bournemouth to Vicarage Road.
West Ham are looking to end a run of two successive wins, which has seen them drop into the bottom-half of the table as they take on Sheffield United at the London Stadium.
The other game sees Brighton host Everton on the South Coast.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Manchester City 12:30 Aston Villa
Etihad Stadium
TEAM NEWS: Leroy Sane and Aymeric Laporte are joined on the sidelines by Rodri and Oleksandr Zinchenko.
Jota is the only player missing for Aston Villa.
KEY FACT: Pep Guardiola has not lost consecutive home league matches since February 2016
MATCH ODDS: Man City 1/12 Draw 10/1 Villa 25/1
bet365 Pick: City win & Under 4.5 goals @5/6
ANDY SAYS: Nothing but a big win coming for City in this one…5-1
GRAEME SAYS: Villa are playing well and I think they could push City really hard, but Pep’s team still win…2-1
Football Index – One to follow: Raheem Sterling – No better play in world football at the moment
Brighton & Hove Albion 15:00 Everton
Amex Stadium
TEAM NEWS: Aaron Mooy is suspended for Brighton who are without Jose Izquierdo and Bernardo.
Morgan Schneiderlin, Yerry Mina Knee and Fabian Delph should make the game, but Jean-Philippe Gbamin and Cenk Tosun are sidelined.
KEY FACT: Brighton are unbeaten in all four previous Premier League fixtures with Everton
MATCH ODDS: Brighton 9/5 Draw 23/10 Everton 8/5
bet365 Pick: Yerry Mina to score anytime @12/1
ANDY SAYS: Brighton are playing well at home and I see them taking the three points…2-0
GRAEME SAYS: Not much in this, but have to go with Everton to make it two from two…1-3
Football Index – One to follow: Richarlison – The Brazilian is a fantastic talent
Watford 15:00 AFC Bournemouth
Vicarage Road
TEAM NEWS: Troy Deeney and Danny Welbeck are both ruled out, but Watford hope to have Sebastian Prodl, Isaac Success and Etienne Capoue back.
Bournemouth are hoping to have Jefferson Lerma available again, but Junior Stanislas, Charlie Daniels, David Brooks and Dan Gosling back again.
KEY FACT: Watford have not beaten Bournemouth at home in eight previous Premier League meetings
MATCH ODDS: Watford 23/20 Draw 13/5 Bournemouth 9/4
bet365 Pick: Watford win @23/20
ANDY SAYS: I don’t think Watford’s horrible run ends here, Bournemouth win…1-3
GRAEME SAYS: I believe Watford will get their first win of the season…2-1
Football Index – One to follow: Aaron Ramsdale – Bournemouth keeper looks a future international
West Ham United 15:00 Sheffield United
London Stadium
TEAM NEWS:Lukasz Fabianski and Michail Antonio miss out for West Ham, who have Aaron Cresswell back and they hope Winston Reid could make it.
The Blades have the luxury of a fully fit squad to choose from.
KEY FACT: West Ham have won only one of their last seven home meetings with Sheffield United in all competitions
MATCH ODDS: West Ham 11/10 Draw 5/2 Sheff Utd 5/2
bet365 Pick: Ryan Fredericks to score anytime @20/1
ANDY SAYS: I think this could be a tight game and Sheff United have been impressive, so they should get a point from this…1-1
GRAEME SAYS: I can see West Ham bouncing back to victory with a solid win in this one…2-0
Football Index – One to follow: Felipe Anderson – A wonderul player, who could soon be set for a big move
Burnley 17:30 Chelsea
Turf Moor
TEAM NEWS: Danny Drinkwater is injured but would not have been allowed to face his former club anyway, whilst Johann Berg Gudmundsson is sidelined. Burnley hope Ashley Barnes, Chris Wood and Jack Cork will be available.
Chelsea could be boosted by having N’Golo Kante and Ross Barkley available but Andreas Christensen, Ruben Loftus-Cheek, Antonio Rudiger and Marco Van Ginkel remain sidelined.
KEY FACT: Frank Lampard is looking to win four successive league matches for the first time in his managerial career
MATCH ODDS: Burnley 7/2 Draw 3/1 Chelsea 8/11
bet365 Pick: Under 2.5 goals @6/5
ANDY SAYS: I think that Chelsea will come unstuck here and Burnley claim a shock win…1-0
GRAEME SAYS: Chelsea are as good as any team at the moment and will get the win here…1-3
Football Index – One to follow: Callum Hudson-Odoi – A truly world-class talent
