Super Sunday very much lives up to its name this week with the top-five all in action.
The opening game of the day sees Tottenham, fresh from their midweek triumph over Real Madrid, host lowly Crystal Palace at Wembley.
Top-of-the-table Manchester City then host Arsenal at The Etihad before their neighbours Manchester United travel to champions Chelsea.
Everton are also in action as interim boss David Unsworth looks for his first win in charge against high-flying Watford at Goodison.
See below for a run-down on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, leading agent Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 12:00 Crystal Palace
Wembley Stadium
Live On BT Sport
TEAM NEWS: Victor Wanyama is out for Spurs and Toby Alderweireld is unlikely to feature but Erik Lamela is back in the fist-team squad. Patrick van Aanholt, Lee Chung-Yong, James McArthur and Mamadou Sakho are all doubts whilst front-men Christian Benteke and Connor Wickham remain sidelined.
KEY FACT: Crystal Palace’s only PL win at Spurs came in November 1997
MATCH ODDS: Spurs 2/7 Draw 5/1 Palace 11/1
bet365 Pick: Spurs clean sheet – no 5/6
ANDY SAYS: My two old clubs, always a fascinating game for me but Spurs to win…3-1
GRAEME SAYS: Might not be as easy as some think, but still a Spurs win…2-0
SILKY SAYS: Don’t see how Palace can take anything here, comfortable home success…3-0
FOOTBALLIndex – One to follow: Dele Alli still under £4 – amazing value
Man City 14:15 Arsenal
Etihad Stadium
Live On Sky Sports
TEAM NEWS: Vincent Kompany and Benjamin Mendy remain sidelined but are their only injury problems. Arsenal are still without Shkodran Mustafi, Danny Welbeck, David Ospina and Calum Chambers but Sead Kolasinac could feature.
KEY FACT: Man City have only won one of their last nine matches against Arsenal in all competitions
MATCH ODDS: Man City 2/5 Draw 9/2 Arsenal 13/2
bet365 Pick: Under 3.5 goals 5/6
ANDY SAYS: I think Arsenal have improved a lot but I have to go with City for the win…2-0
GRAEME SAYS: I think we could see goals here but City will come on top…3-1
SILKY SAYS: You have to go with Man City here, I don’t see how they don’t win…2-1
FOOTBALLIndex – One to follow: Gabriel Jesus at under £4 – huge bargain
Chelsea 16:30 Man Utd
Stamford Bridge
Live On Sky Sports
TEAM NEWS: Chelsea are hoping N’Golo Kante will be back from his thigh problem but Victor Moses is out. Michael Carrick, Marouane Fellaini, Zlatan Ibrahimovic and Marcos Rojo are sidelined – but Paul Pogba and Jesse Lingard could return.
KEY FACT: Chelsea have lost only one of their last 15 home Premier League matches against Man Utd
MATCH ODDS: Chelsea 6/4 Draw 11/5 Man Utd 11/5
bet365 Pick: Both Team To Score 19/20
ANDY SAYS: Such a close call – I can’t separate the two teams, has to be a draw…1-1
GRAEME SAYS: I can see Man Utd sneaking a win here but it will be close…1-2
SILKY SAYS: I have to give Chelsea the benefit of the doubt, so home win…2-1
FOOTBALLIndex – One to follow: Eden Hazard at just £3.83 – has to be bought!
Everton 16:30 Watford
Goodison Park
TEAM NEWS: Troy Deeney is serving his one-match suspension, whilst Seb Prodl and Younes Kaboul are still out. Cuco Martina misses out for Everton, but Michael Keane should return from a foot problem.
KEY FACT: Watford have won only one point from their 10 previous league visits to Goodison Park
MATCH ODDS: Everton 6/5 Draw 12/5 Watford 13/5
bet365 Pick: A red card in the match 9/2
ANDY SAYS: Tough call again, but not sure Everton are going to win this one…1-1
GRAEME SAYS: I think Watford could win this and turn up the heat on Everton…1-2
SILKY SAYS: I can see Watford claiming the three points here, Everton are that bad…1-2
FOOTBALLIndex – One to follow: Wayne Rooney at £1.39 – is he a good option? Could be…