Super Sunday lives up to his billing this week with five of the top seven in action.
The undoubted game of the weekend sees Arsenal host Manchester United as the battle for the top-four heats up.
Liverpool looks to keep up the pressure on leaders Manchester City as they welcome Burnley to Anfield.
The final game is another fascinating contest as Wolves travel to Stamford Bridge to face Chelsea.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Liverpool 12:00 Burnley
TEAM NEWS: Dejan Lovren could return for Liverpool, whilst Alex Oxlade-Chamberlain has returned to training. Joe Gomez is still sidelined.
Steven Defour and Aaron Lennon are still ruled out for Burnley.
KEY FACT: Liverpool have not lost at home to Burnley since 1971
MATCH ODDS: Liverpool 1/6 Draw 15/2 Burnley 20/1
bet365 Pick: Under 3.5 goals @8/11
ANDY SAYS: Liverpool will ease to victory in this one…3-0
GRAEME SAYS: Burnley could be tough to break down, but Liverpool will win…2-0
Football Index – One to follow: Sadio Mane – Due to step it up again, could be key in the run-in
Chelsea 14:05 Wolverhampton Wanderers
TEAM NEWS: Chelsea have a near fully fit squad to choose from with only Danny Drinkwater and Marco van Ginkel sidelined.
Wolves come into the game with the luxury of a fully fit squad for Nuno to choose from.
KEY FACT: Chelsea have only lost one of their last 53 home league matches against promoted sides
MATCH ODDS: Chelsea 8/15 Draw 10/3 Wolves 6/1
bet365 Pick: Both Teams To Score @10/11
ANDY SAYS: A close game but Chelsea need the win, and I think they just about get it…2-1
GRAEME SAYS: I think Wolves will get something here, they are a very good team so a draw for me…2-2
Football Index – One to follow: Ruben Neves – A potential superstar in Wolves’ midfield
Arsenal 16:30 Manchester United
TEAM NEWS: No team in the Premier League has more players missing than United who have Alexis Sanchez, Ander Herrera, Jesse Lingard, Juan Mata and Antonio Valencia sidelined. United hope that Nemanja Matic, Phil Jones, Anthony Martial, Matteo Darmian and Eric Bailly could feature.
Hector Bellerin, Rob Holding and Danny Welbeck all miss out for Arsenal.
KEY FACT: Alexandre Lacazette can become the first Arsenal player to score in six consecutive PL home matches at the Emirates
MATCH ODDS: Arsenal 7/5 Draw 13/5 Man Utd 2/1
bet365 Pick: Arsenal to win @7/5
ANDY SAYS: Good game, no doubt and I just have to side with Arsenal to inflict a first league defeat on Ole…2-1
GRAEME SAYS: United are suffering with injuries, good game but I can see them cancelling each other out…0-0
Football Index – One to follow: Marcus Rashford – He is heading for the top, invest in him now