Sunday sees Liverpool continue their title battle with a trip to South Wales.
The Reds need to keep up the pressure on rivals Manchester City, but they face a Cardiff side in desperate need of three points as they continue their battle against relegation.
The other two games take in the battle for the top-four, as Manchester United travel to Everton whilst Arsenal entertain Crystal Palace in a capital derby clash.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Everton 13:30 Manchester United
TEAM NEWS: Everton are without loan stars Andre Gomes and Yerry Mina. Gomes is suspended, whilst Mina is injured.
Antonio Valencia and Eric Bailly both miss out, along with the suspended Luke Shaw, but Ander Herrera should be available again.
KEY FACT: United have lost their last two away matches in the league. They have not lost three in a row on the road since January 1996
MATCH ODDS: Everton 9/4 Draw 5/2 Man Utd 13/10
bet365 Pick: Draw @5/2
ANDY SAYS: Close game, always a good contest and I think Everton claim a draw…1-1
GRAEME SAYS: I think that United can recover some form here and claim a narrow win…1-2
Football Index – One to follow: Marcus Rashford – A wonderful talent and plenty of value left in him
Arsenal 16:00 Crystal Palace
TEAM NEWS: Aaron Ramsey and Denis Suarez have joined Rob Holding, Hector Bellerin and Danny Welbeck on the sidelines.
Palace come into the game without defenders Mamadou Sakho and James Tomkins, along with Jeffrey Schlupp.
KEY FACT: Arsenal can win an 11th successive home match within a single top-flight season for the first time
MATCH ODDS: Arsenal 8/15 Draw 7/2 Palace 11/2
bet365 Pick: Arsenal & Over 2.5 goals @11/10
ANDY SAYS: I can see my former club getting a result here in what will be a decent game…2-2
GRAEME SAYS: Has to be a home win, Arsenal will be too strong and Palace have little play for…2-0
Football Index – One to follow: Alex Iwobi – Playing some good stuff, under the radar and one to be looked at
Cardiff City 16:00 Liverpool
Cardiff City Stadium
TEAM NEWS: Liverpool are approaching a fully fit squad with Dejan Lovren and Adam Lallana the only major doubts.
Cardiff are only without Sol Bamba, Callum Paterson and Matthew Connolly, but they hope to have Harry Arter back.
KEY FACT: Cardiff have never beaten Liverpool in the Premier League
MATCH ODDS: Cardiff 16/1 Draw 13/2 Liverpool 1/5
bet365 Pick: Both Teams To Score @5/4
ANDY SAYS: Tough call here for Cardiff and Liverpool will just be too good…1-3
GRAEME SAYS: Liverpool will defeat Cardiff, might not be easy but it’s an away win…0-2
Football Index – One to follow: Alex Oxlade-Chamberlain – Coming back to fitness, is one to watch on the Index