The final game of the Premier League week takes place at Wembley with another capital derby clash.
Spurs in fifth could move to within a point of Liverpool in fourth with victory.
West Ham are just a point off the bottom three so are in need of as many points as they can.
See below for a preview on the game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray, super agent and former Manchester City ace Barry Silkman, our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Tottenham Hotspur 20:00 West Ham United
Wembley Stadium
Live on Sky Sports
TEAM NEWS: Danny Rose and and Toby Alderweireld remain sidelined for Tottenham but Moussa Dembele should be fit. Reece Oxford is a doubt for West Ham, but Aaron Cresswell, Sam Byram, Jose Fonte and James Collins are all out.
KEY FACT: West Ham have played three competitive London derbies at Wembley Stadium and won them all
MATCH ODDS: Spurs 2/7 Draw 5/1 West Ham 11/1
bet365 Pick: Spurs to win to nil @21/20
ANDY SAYS: Have to go with my former side here, they will win…2-0
GRAEME SAYS: West Ham could give Spurs a close game here but home win…2-1
SILKY SAYS: Comfortable home win here, no doubt a Spurs win…4-0
FOOTBALLIndex – One to follow: Just over £2 and just inside top-50 Christian Eriksen is a good choice