The only two teams not in action on Boxing Day are Southampton and West Ham United, who meet on Thursday.
Southampton are looking for a third successive win, whilst West Ham are looking to return to winning ways after losing to Watford last time out.
See below for a preview on the game, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Southampton 19:45 West Ham United
St Mary’s
TEAM NEWS: The only player missing out for Southampton is Ryan Bertrand.
Nobody has more injury problems in the Premier League than West Ham. They hope to have Fabian Balbuena, Javier Hernandez and Lucas Perez available, but Marko Arnautovic, Jack Wilshere, Ryan Fredericks, Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini all sidelined.
KEY FACT: Southampton have lost only one of their last nine home league matches against West Ham
MATCH ODDS: Southampton 6/5 Draw 13/5 West Ham 2/5
bet365 Pick: Both Teams To Score & Over 2.5 goals @Evens
ANDY SAYS: Southampton are much improved in recent weeks but I can still see West Ham getting something here…1-1
GRAEME SAYS: I can see Southampton’s good run continuing here with a win…1-0
Football Index – One to follow: Mario Lemina – still a huge talent and is value