Manchester City look to move to within one point of leaders Liverpool on Tuesday evening.
Champions City travel to Tyneside to take on Newcastle – who remain just two points above the drop-zone.
Arsenal and Manchester United both have the chance to go level with Chelsea in fourth place – with The Blues not playing until Wednesday.
The Gunners host Cardiff City – who play their first game since the loss of their star striker Emiliano Sala in a plane crash.
United could make it nine successive wins for interim boss Ole Gunnar Solskjaer and a victory over Burnley at Old Trafford would see him record seven successive league games, and set a new Premier League record.
New Huddersfield boss Jan Siewert takes charge of his first game since succeeding David Wagner against Everton at the John Smith’s Stadium.
Second bottom Fulham are in desperate need of a win after three successive defeats, and Claudio Ranieri will be looking to put that right at home to Brighton.
The final game sees West Ham travel to Wolves – victory for either side would lift them to seventh in the table.
See below for a preview on the games, including predictions from former England, Crystal Palace and Tottenham midfielder Andy Gray and our own Football Insider Graeme Bailey and bet365’s Steve Freeth.
Arsenal 19:45 Cardiff City
TEAM NEWS: Laurent Koscielny has joined fellow defenders Sokratis, Hector Bellerin and Rob Holding on the sidelines, whilst Danny Welbeck and Henrikh Mkhitaryan are also out.
Defendner Sean Morrison misses out for Cardiff, who hope to have Kenneth Zohore and Harry Arter back.
KEY FACT: Cardiff have lost their last six away games against Arsenal in all competitions.
MATCH ODDS: Arsenal 1/4 Draw 28/5 Cardiff 12/1
bet365 Pick: Arsenal to win & Under 3.5 goals @13/10
ANDY SAYS: Don’t see too many issues for Arsenal here, home win…3-0
GRAEME SAYS: Tough ask for Cardiff to get anything and think Arsenal win here…2-0
Football Index – One to follow: Pierre-Emerick Aubameyang – a top player, needs to be considered for any portfolio
Fulham 19:45 Brighton & Hove Albion
TEAM NEWS: Alfie Mawson and Andre-Frank Zambo Anguissa remain sidelined, whilst Aboubakar Kamara is suspended by the club.
Brighton goalkeeper Mat Ryan is available for the first time since Boxing Day after returning from the Asian Cup, whilst Leon Balogun is also available.
Bernardo and Jose Izquierdo remain sidelined.
KEY FACT: Brighton have won three successive league games at Craven Cottage
MATCH ODDS: Fulham 11/8 Draw 11/5 Brighton 12/5
bet365 Pick: Both Teams To Score @19/20
ANDY SAYS: More misery coming for Fulham, I see Brighton winning this…1-2
GRAEME SAYS: There will be goals here but I can see them playing out a draw…2-2
Football Index – One to follow: Ryan Sessegnon – may not have had the season he wanted but still a huge talent
Huddersfield Town 19:45 Everton
John Smith’s Stadium
TEAM NEWS: Aaron Mooy is set to make his return for Huddersfield, along with Abdelhamid Sabiri but Philip Billing and Danny Williams are still sidelined.
Everton are without defenders Phil Jagielka and Yerry Mina. It remains to be seen if Idrissa Gueye will feature, after he handed in a transfer request.
KEY FACT: Everton have kept a clean sheet in three of their past four top-flight meetings with Huddersfield
MATCH ODDS: Huddersfield 3/1 Draw 23/10 Everton 11/10
bet365 Pick: Both Teams To Score @19/20
ANDY SAYS: Close game and I think Huddersfield’s new boss lands a point on his debut…1-1
GRAEME SAYS: Everton are not in great form and I can see them coming unstuck here with Huddersfield’s new boss…1-0
Football Index – One to follow: Richarlison – a sensational player who is only going one way, well worth investing in
Wolverhampton Wanderers 19:45 West Ham United
TEAM NEWS: Wolves are without suspended defender Willy Boly, but that aside they have a full fit squad.
Marko Arnautovic and Ryan Fredericks could return, but Lucas Perez is unlikely to feature and joins to West Ham’s lengthy injury list which already contains Jack Wilshere, Fabian Balbuena, Andriy Yarmolenko, Carlos Sanchez, Winston Reid and Manuel Lanzini.
KEY FACT: West Ham in a top-flight game at Molineux since a 2-1 victory in 1982
MATCH ODDS: Wolves 11/10 Draw 5/2 West Ham 11/4
bet365 Pick: Under 2.5 goals @10/11
ANDY SAYS: A very good game coming up here, but I have to side with Wolves…2-0
GRAEME SAYS: A close one here for sure, but I just think Wolves will edge it…2-1
Football Index – One to follow: Ruben Neves – a remarkably good player, who should be invested in
Manchester United 20:00 Burnley
TEAM NEWS: Marcos Rojo and Marouane Fellaini remain sidelined for United, but Chris Smalling could return.
Matt Lowton and Aaron Lennon miss-out for Burnley – but Robbie Brady, Johann Berg Gudmundsson and Phil Bardsley could feature and will face fitness tests.
KEY FACT: United are unbeaten in 19 home games against Burnley in all competitions dating back to 1962
MATCH ODDS: Man Utd 2/7 Draw 5/1 Burnley 12/1
bet365 Pick: Under 2.5 goals @6/4
ANDY SAYS: Ole Gunnar will get his record here, I don’t think there is much about it…3-1
GRAEME SAYS: Hard to see United getting beat and they won’t…2-0
Football Index – One to follow: Marcus Rashford – a huge talent, who needs to be in your portfolio
Newcastle United 20:00 Manchester City
St James’ Park
TEAM NEWS: Newcastle are without striker Joselu along with midfielders Mohamed Diame, Jonjo Shelvey and Ki Sung-yueng.
Vincent Kompany and Claudio Bravo are ruled out for Man City, who are hoping Benjamin Mendy will be OK to start.
KEY FACT: Newcastle are winless in their last 22 Premier League games against City
MATCH ODDS: Newcastle 18/1 Draw 7/1 Man City 2/11
bet365 Pick: Man City to win & Under 3.5 goals @21/20
ANDY SAYS: Newcastle are poor and City will sweep them aside…0-4
GRAEME SAYS: I don’t see how Newcastle can trouble City, away win…0-2
Football Index – One to follow: Kevin De Bruyne – best player in the world? Quite possibly so well worth investing in